Results 1 to 10 of about 362,447 (161)
Journal of Enzyme Inhibition and Medicinal Chemistry, 2021 COVID-19, a pandemic disease caused by a viral infection, is associated with a high mortality rate. Most of the signs and symptoms, e.g. cytokine storm, electrolytes imbalances, thromboembolism, etc., are related to mitochondrial dysfunction.
Stephan Reshkin +2 more
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Mitochondrion-specific dendritic lipopeptide liposomes for targeted sub-cellular delivery
Nature Communications, 2021 The mitochondrion is an important sub-cellular organelle responsible for the cellular energetic source and processes. Owing to its unique sensitivity to heat and reactive oxygen species, the mitochondrion is an appropriate target for photothermal and ...
Lei Jiang +6 more
doaj +2 more sources
Mitochondrion-targeted RNA therapies as a potential treatment strategy for mitochondrial diseases
Molecular Therapy - Nucleic Acids, 2022 Summary Mitochondrial diseases are one of the largest groups of neurological genetic disorders. Despite continuous efforts of the scientific community, no cure has been developed, and most treatment strategies rely on managing the symptoms.
Andreazza Ac +2 more
exaly +2 more sources
Pyrophosphate homeostasis in multiple subcellular compartments is essential in Plasmodium falciparum [PDF]
mBioPyrophosphate is a byproduct of numerous cellular reactions that use ATP or other nucleoside triphosphates to synthesize DNA, RNA, protein, and various molecules.
Ikechukwu Nwankwo, Hangjun Ke
doaj +2 more sources
Cell Reports, 2017 Summary: A number of mitochondrial diseases arise from single-nucleotide variant (SNV) accumulation in multiple mitochondria. Here, we present a method for identification of variants present at the single-mitochondrion level in individual mouse and human
Jai-Yoon Sul +2 more
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mBio, 2020 Toxoplasma gondii’s single mitochondrion is very dynamic and undergoes morphological changes throughout the parasite’s life cycle. During parasite division, the mitochondrion elongates, enters the daughter cells just prior to cytokinesis, and undergoes ...
Kylie Jacobs +2 more
doaj +2 more sources
AMPK regulates ARF1 localization to membrane contact sites to facilitate fatty acid transfer between lipid droplets and mitochondria [PDF]
Cell Death and DiseaseLipid droplet (LD) -mitochondrion contacts play a crucial role in regulating energy metabolism and fatty acid oxidation in skeletal muscle cells. However, the proteins that regulate these interactions remain poorly understood.
Lupeng Chen +5 more
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Optical Properties and Interference Effects of the Lens Mitochondrion
Membranes, 2023 The lens mitochondrion of the tree shrew, located along the optical pathway between the lens and photoreceptors, has been investigated. The results suggest that the lens mitochondrion acts as a quasi-bandgap or imperfect photonic crystal.
Felix Margadant +3 more
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Quality control of the mitochondrion.
Developmental Cell, 2021 Mitochondria are essential organelles that execute and coordinate various metabolic processes in the cell. Mitochondrial dysfunction severely affects cell fitness and contributes to disease.
Matthew Yoke Wui Ng, T. Wai, A. Simonsen
semanticscholar +1 more source
Cells, 2021 Emerging evidence suggests that mitochondrion–endoplasmic reticulum (ER) and mitochondrion–lipid droplet (LD) contact sites are critical in regulating lipid metabolism in cells.
Xiaowen Ma +4 more
doaj +1 more source