Results 1 to 10 of about 337,106 (263)

AMPK regulates ARF1 localization to membrane contact sites to facilitate fatty acid transfer between lipid droplets and mitochondria [PDF]

Cell Death and Disease
Lipid droplet (LD) -mitochondrion contacts play a crucial role in regulating energy metabolism and fatty acid oxidation in skeletal muscle cells. However, the proteins that regulate these interactions remain poorly understood.
Lupeng Chen, Yue Liu, Junzhi Zhang, Tongxing Song, Jian Wu, Zhuqing Ren   +5 more
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Optical Properties and Interference Effects of the Lens Mitochondrion

Membranes, 2023
The lens mitochondrion of the tree shrew, located along the optical pathway between the lens and photoreceptors, has been investigated. The results suggest that the lens mitochondrion acts as a quasi-bandgap or imperfect photonic crystal.
Felix Margadant, Zakaria Almsherqi, Xiaochun Xu, Yuru Deng   +3 more
doaj   +1 more source

Perspectives on Mitochondria–ER and Mitochondria–Lipid Droplet Contact in Hepatocytes and Hepatic Lipid Metabolism

Cells, 2021
Emerging evidence suggests that mitochondrion–endoplasmic reticulum (ER) and mitochondrion–lipid droplet (LD) contact sites are critical in regulating lipid metabolism in cells.
Xiaowen Ma, Hui Qian, Allen Chen, Hong-Min Ni, Wen-Xing Ding   +4 more
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Mitochondrion-specific dendritic lipopeptide liposomes for targeted sub-cellular delivery

Nature Communications, 2021
The mitochondrion is an important sub-cellular organelle responsible for the cellular energetic source and processes. Owing to its unique sensitivity to heat and reactive oxygen species, the mitochondrion is an appropriate target for photothermal and ...
Lei Jiang, Sensen Zhou, Xiaoke Zhang, Cheng Li, Shilu Ji, Hui Mao, Xiqun Jiang   +6 more
doaj   +1 more source

Of mitochondrion and COVID-19

Journal of Enzyme Inhibition and Medicinal Chemistry, 2021
COVID-19, a pandemic disease caused by a viral infection, is associated with a high mortality rate. Most of the signs and symptoms, e.g. cytokine storm, electrolytes imbalances, thromboembolism, etc., are related to mitochondrial dysfunction.
Khalid Omer Alfarouk, Sari T. S. Alhoufie, Abdelhameed Hifny, Laurent Schwartz, Ali S. Alqahtani, Samrein B. M. Ahmed, Ali M. Alqahtani, Saad S. Alqahtani, Abdel Khalig Muddathir, Heyam Ali, Adil H. H. Bashir, Muntaser E. Ibrahim, Maria Raffaella Greco, Rosa A. Cardone, Salvador Harguindey, Stephan Joel Reshkin   +15 more
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Inventory and Evolution of Mitochondrion-localized Family A DNA Polymerases in Euglenozoa

Pathogens, 2020
The order Trypanosomatida has been well studied due to its pathogenicity and the unique biology of the mitochondrion. In Trypanosoma brucei, four DNA polymerases, namely PolIA, PolIB, PolIC, and PolID, related to bacterial DNA polymerase I (PolI), were ...
Ryo Harada, Yoshihisa Hirakawa, Akinori Yabuki, Yuichiro Kashiyama, Moe Maruyama, Ryo Onuma, Petr Soukal, Shinya Miyagishima, Vladimír Hampl, Goro Tanifuji, Yuji Inagaki   +10 more
doaj   +1 more source

ZmnMAT1, a nuclear-encoded type I maturase, is required for the splicing of mitochondrial Nad1 intron 1 and Nad4 intron 2

Frontiers in Plant Science, 2022
Maturases can specifically bind to intron-containing pre-RNAs, folding them into catalytic structures that facilitate intron splicing in vivo. Plants possess four nuclear-encoded maturase-related factors (nMAT1-nMAT4) and some maturases have been shown ...
Kaijian Fan, Qinghui Fu, Qianhan Wei, Sinian Jia, Anqi Zhao, Tengteng Wang, Jie Cao, Yan Liu, Zhenjing Ren, Yunjun Liu   +9 more
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A Note on the Consequences of a Hot Mitochondrion: Some Recent Developments and Open Questions

Біофізичний вісник, 2020
Background: Chrétien and co-workers (PLOS Biology. 2018;16(1):e2003992) recently suggested that the mitochondrion might possibly be hotter than its surrounding (by as much as 10°C).
Peyman Fahimi, Mohamed A. Nasr, Lazaro M. A. Castanedo, Youji Cheng, Cyrus Ahmady Toussi, Cherif Farid Matta   +5 more
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Metformin ameliorates the mitochondrial damage induced by C9ORF72 amyotrophic lateral sclerosis/frontotemporal dementia-related poly-GR

Shanghai Jiaotong Daxue xuebao. Yixue ban, 2023
Objective·To investigate the effect of C9ORF72 amyotrophic lateral sclerosis/frontotemporal dementia (ALS/FTD)-related poly-glycine-arginine (poly-GR) on mitochondrial morphology and function, and analyze the rescue effect of metformin on mitochondrial ...
FENG Yiyuan, XU Zhongyun, YIN Yafu, WANG Hui, CHENG Weiwei   +4 more
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Cytoprotective Effects of Punicalagin on Hydrogen–Peroxide–Mediated Oxidative Stress and Mitochondrial Dysfunction in Retinal Pigment Epithelium Cells

Antioxidants, 2021
The retinal pigment epithelium (RPE) is a densely pigmented, monostratified epithelium that provides metabolic and functional support to the outer segments of photoreceptors. Endogenous or exogenous oxidative stimuli determine a switch from physiological
Maria Elisabetta Clementi, Giuseppe Maulucci, Giada Bianchetti, Michela Pizzoferrato, Beatrice Sampaolese, Giuseppe Tringali   +5 more
doaj   +1 more source