Results 1 to 10 of about 64,693 (348)

Of mitochondrion and COVID-19

Journal of Enzyme Inhibition and Medicinal Chemistry, 2021
COVID-19, a pandemic disease caused by a viral infection, is associated with a high mortality rate. Most of the signs and symptoms, e.g. cytokine storm, electrolytes imbalances, thromboembolism, etc., are related to mitochondrial dysfunction.
Khalid Omer Alfarouk, Sari T. S. Alhoufie, Abdelhameed Hifny, Laurent Schwartz, Ali S. Alqahtani, Samrein B. M. Ahmed, Ali M. Alqahtani, Saad S. Alqahtani, Abdel Khalig Muddathir, Heyam Ali, Adil H. H. Bashir, Muntaser E. Ibrahim, Maria Raffaella Greco, Rosa A. Cardone, Salvador Harguindey, Stephan Joel Reshkin   +15 more
doaj   +2 more sources

Identification of Fis1 Interactors in Toxoplasma gondii Reveals a Novel Protein Required for Peripheral Distribution of the Mitochondrion

mBio, 2020
Toxoplasma gondii’s single mitochondrion is very dynamic and undergoes morphological changes throughout the parasite’s life cycle. During parasite division, the mitochondrion elongates, enters the daughter cells just prior to cytokinesis, and undergoes ...
Kylie Jacobs, Robert Charvat, Gustavo Arrizabalaga   +2 more
doaj   +2 more sources

Optical Properties and Interference Effects of the Lens Mitochondrion

Membranes, 2023
The lens mitochondrion of the tree shrew, located along the optical pathway between the lens and photoreceptors, has been investigated. The results suggest that the lens mitochondrion acts as a quasi-bandgap or imperfect photonic crystal.
Felix Margadant, Zakaria Almsherqi, Xiaochun Xu, Yuru Deng   +3 more
doaj   +1 more source

Perspectives on Mitochondria–ER and Mitochondria–Lipid Droplet Contact in Hepatocytes and Hepatic Lipid Metabolism

Cells, 2021
Emerging evidence suggests that mitochondrion–endoplasmic reticulum (ER) and mitochondrion–lipid droplet (LD) contact sites are critical in regulating lipid metabolism in cells.
Xiaowen Ma, Hui Qian, Allen Chen, Hong-Min Ni, Wen-Xing Ding   +4 more
doaj   +1 more source

Mitochondrion-specific dendritic lipopeptide liposomes for targeted sub-cellular delivery

Nature Communications, 2021
The mitochondrion is an important sub-cellular organelle responsible for the cellular energetic source and processes. Owing to its unique sensitivity to heat and reactive oxygen species, the mitochondrion is an appropriate target for photothermal and ...
Lei Jiang, Sensen Zhou, Xiaoke Zhang, Cheng Li, Shilu Ji, H. Mao, Xiqun Jiang   +6 more
semanticscholar   +1 more source

The Hot Mitochondrion Paradox: Reconciling Theory and Experiment [PDF]

Trends in Chemistry 4 (2), 4-20 (2022), 2021
Experiments by Chretien and co-workers suggest that mitochondria are 10oC hotter than their surroundings. Steady-state theoretical estimates place this difference at a maximum of 10^-5 oC. This million-fold disagreement may be called the hot mitochondrion paradox.
arxiv   +1 more source

IMC10 and LMF1 mediate mitochondrial morphology through mitochondrion–pellicle contact sites in Toxoplasma gondii

Journal of Cell Science, 2022
The single mitochondrion of Toxoplasma gondii is highly dynamic, being predominantly in a peripherally distributed lasso-shape in intracellular parasites and collapsed in extracellular parasites.
R. Souza, Kylie Jacobs, Peter S. Back, P. Bradley, G. Arrizabalaga   +4 more
semanticscholar   +1 more source

ORP1L mediated PI(4)P signaling at ER-lysosome-mitochondrion three-way contact contributes to mitochondrial division

Nature Communications, 2021
Mitochondrial division is not an autonomous event but involves multiple organelles, including the endoplasmic reticulum (ER) and lysosomes. Whereas the ER drives the constriction of mitochondrial membranes, the role of lysosomes in mitochondrial division
Maxime Boutry, P. Kim
semanticscholar   +1 more source

Inventory and Evolution of Mitochondrion-localized Family A DNA Polymerases in Euglenozoa

Pathogens, 2020
The order Trypanosomatida has been well studied due to its pathogenicity and the unique biology of the mitochondrion. In Trypanosoma brucei, four DNA polymerases, namely PolIA, PolIB, PolIC, and PolID, related to bacterial DNA polymerase I (PolI), were ...
Ryo Harada, Yoshihisa Hirakawa, Akinori Yabuki, Yuichiro Kashiyama, Moe Maruyama, Ryo Onuma, Petr Soukal, Shinya Miyagishima, Vladimír Hampl, Goro Tanifuji, Yuji Inagaki   +10 more
doaj   +1 more source

A Note on the Consequences of a Hot Mitochondrion: Some Recent Developments and Open Questions

Біофізичний вісник, 2020
Background: Chrétien and co-workers (PLOS Biology. 2018;16(1):e2003992) recently suggested that the mitochondrion might possibly be hotter than its surrounding (by as much as 10°C).
Peyman Fahimi, Mohamed A. Nasr, Lazaro M. A. Castanedo, Youji Cheng, Cyrus Ahmady Toussi, Cherif Farid Matta   +5 more
doaj   +1 more source