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Identification of Fis1 Interactors in
mBio, 2020 Toxoplasma gondii’s single mitochondrion is very dynamic and undergoes morphological changes throughout the parasite’s life cycle. During parasite division, the mitochondrion elongates, enters the daughter cells just prior to cytokinesis, and undergoes ...
Kylie Jacobs +2 more
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Quality control of the mitochondrion [PDF]
Developmental Cell, 2021 Mitochondria are essential organelles that execute and coordinate various metabolic processes in the cell. Mitochondrial dysfunction severely affects cell fitness and contributes to disease. Proper organellar function depends on the biogenesis and maintenance of mitochondria and its1,000 proteins.
Ng, Matthew, Yoke Wui +2 more
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Journal of Enzyme Inhibition and Medicinal Chemistry, 2021 COVID-19, a pandemic disease caused by a viral infection, is associated with a high mortality rate. Most of the signs and symptoms, e.g. cytokine storm, electrolytes imbalances, thromboembolism, etc., are related to mitochondrial dysfunction.
Khalid Omer Alfarouk +15 more
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Inventory and Evolution of Mitochondrion-localized Family A DNA Polymerases in Euglenozoa [PDF]
Pathogens, 2020 The order Trypanosomatida has been well studied due to its pathogenicity and the unique biology of the mitochondrion. In Trypanosoma brucei, four DNA polymerases, namely PolIA, PolIB, PolIC, and PolID, related to bacterial DNA polymerase I (PolI), were ...
Ryo Harada +10 more
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The mitochondrion as a hammer [PDF]
Evolution: Education and Outreach, 2020 This is a review of Mitonuclear Ecology by Geoffrey E. Hill, which discusses the potential role of mitochondrial-nuclear (mitonuclear) interactions in key evolutionary processes.
Logan W. Cole
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Cell Biology of the Mitochondrion [PDF]
Genetics, 2017 AbstractMitochondria are best known for harboring pathways involved in ATP synthesis through the tricarboxylic acid cycle and oxidative phosphorylation. Major advances in understanding these roles were made with Caenorhabditiselegans mutants affecting key components of the metabolic pathways.
van der Bliek, Alexander M +2 more
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Towards a Synthetic Mitochondrion
CHIMIA, 2018 Our group at the University of Bern uses biochemical and biophysical techniques to unravel details of the molecular mechanism of membrane proteins.
Olivier Biner +3 more
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The return of the mitochondrion [PDF]
The Biochemist, 2005 For a fresh-faced (well, apart from the beard) PhD graduate in 1989, mitochondrial bioenergetics might have seemed a strange choice of research path. Flushed with the general acceptance of the chemiosmotic theory, many felt that the area had passed its heyday. With the publication of its ‘bible’ (Bioenergetics, the definitive textbook by David Nicholls)
Chris E. Cooper
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Protein translocation pathways of the mitochondrion [PDF]
FEBS Letters, 2000 The biogenesis of mitochondria depends on the coordinated import of precursor proteins from the cytosol coupled with the export of mitochondrially coded proteins from the matrix to the inner membrane. The mitochondria contain an elaborate network of protein translocases in the outer and inner membrane along with a battery of chaperones and processing ...
Carla M. Koehler
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On the InterAktion between Hexokinase and the Mitochondrion [PDF]
Developmental Cell, 2004 The protein kinase Akt is now well recognized as a potent inhibitor of apoptosis. Work published by Majewski et al. in the December 3rd issue of Molecular Cell indicates that a major pathway by which Akt suppresses cell death is by stimulating the translocation of hexokinase to the mitochondrion.
Morris J. Birnbaum
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