Results 1 to 10 of about 338,550 (257)

AMPK regulates ARF1 localization to membrane contact sites to facilitate fatty acid transfer between lipid droplets and mitochondria [PDF]

Cell Death and Disease
Lipid droplet (LD) -mitochondrion contacts play a crucial role in regulating energy metabolism and fatty acid oxidation in skeletal muscle cells. However, the proteins that regulate these interactions remain poorly understood.
Lupeng Chen, Yue Liu, Junzhi Zhang, Tongxing Song, Jian Wu, Zhuqing Ren   +5 more
doaj   +2 more sources

Of mitochondrion and COVID-19 [PDF]

Journal of Enzyme Inhibition and Medicinal Chemistry, 2021
COVID-19, a pandemic disease caused by a viral infection, is associated with a high mortality rate. Most of the signs and symptoms, e.g. cytokine storm, electrolytes imbalances, thromboembolism, etc., are related to mitochondrial dysfunction.
Khalid Omer Alfarouk, Sari T. S. Alhoufie, Abdelhameed Hifny, Laurent Schwartz, Ali S. Alqahtani, Samrein B. M. Ahmed, Ali M. Alqahtani, Saad S. Alqahtani, Abdel Khalig Muddathir, Heyam Ali, Adil H. H. Bashir, Muntaser E. Ibrahim, Maria Raffaella Greco, Rosa A. Cardone, Salvador Harguindey, Stephan Joel Reshkin   +15 more
doaj   +4 more sources

Trypanocidal Activity of Dual Redox-Active Quinones: Trypanosoma cruzi Mitochondrion as a Target Organelle In Vitro and Anti-Inflammatory Properties In Vivo [PDF]

Pathogens
Chagas disease is caused by the protozoan Trypanosoma cruzi, and its current treatment is limited to the use of two nitroderivatives, benznidazole (Bz) and nifurtimox; however, their toxicity often leads to discontinuation, justifying the search for new ...
Raquel B. Duarte, Victor F. S. Ramos, Juliana M. C. Barbosa, Gabriel M. Oliveira, Emilay B. T. Diogo, Renata G. Almeida, Alastair J. J. Lennox, Eufrânio N. da Silva Júnior, Yasmin Pedra-Rezende, Rubem F. S. Menna-Barreto   +9 more
doaj   +2 more sources

Optical Properties and Interference Effects of the Lens Mitochondrion

Membranes, 2023
The lens mitochondrion of the tree shrew, located along the optical pathway between the lens and photoreceptors, has been investigated. The results suggest that the lens mitochondrion acts as a quasi-bandgap or imperfect photonic crystal.
Felix Margadant, Zakaria Almsherqi, Xiaochun Xu, Yuru Deng   +3 more
doaj   +1 more source

Perspectives on Mitochondria–ER and Mitochondria–Lipid Droplet Contact in Hepatocytes and Hepatic Lipid Metabolism

Cells, 2021
Emerging evidence suggests that mitochondrion–endoplasmic reticulum (ER) and mitochondrion–lipid droplet (LD) contact sites are critical in regulating lipid metabolism in cells.
Xiaowen Ma, Hui Qian, Allen Chen, Hong-Min Ni, Wen-Xing Ding   +4 more
doaj   +1 more source

Mitochondrion-specific dendritic lipopeptide liposomes for targeted sub-cellular delivery

Nature Communications, 2021
The mitochondrion is an important sub-cellular organelle responsible for the cellular energetic source and processes. Owing to its unique sensitivity to heat and reactive oxygen species, the mitochondrion is an appropriate target for photothermal and ...
Lei Jiang, Sensen Zhou, Xiaoke Zhang, Cheng Li, Shilu Ji, Hui Mao, Xiqun Jiang   +6 more
doaj   +1 more source

Inventory and Evolution of Mitochondrion-localized Family A DNA Polymerases in Euglenozoa

Pathogens, 2020
The order Trypanosomatida has been well studied due to its pathogenicity and the unique biology of the mitochondrion. In Trypanosoma brucei, four DNA polymerases, namely PolIA, PolIB, PolIC, and PolID, related to bacterial DNA polymerase I (PolI), were ...
Ryo Harada, Yoshihisa Hirakawa, Akinori Yabuki, Yuichiro Kashiyama, Moe Maruyama, Ryo Onuma, Petr Soukal, Shinya Miyagishima, Vladimír Hampl, Goro Tanifuji, Yuji Inagaki   +10 more
doaj   +1 more source

Organellar Evolution: A Path from Benefit to Dependence

Microorganisms, 2022
Eukaryotic organelles supposedly evolved from their bacterial ancestors because of their benefits to host cells. However, organelles are quite often retained, even when the beneficial metabolic pathway is lost, due to something other than the original ...
Miroslav Oborník
doaj   +1 more source

Presence of a Mitovirus Is Associated with Alteration of the Mitochondrial Proteome, as Revealed by Protein–Protein Interaction (PPI) and Co-Expression Network Models in Chenopodium quinoa Plants

Biology, 2022
Plant mitoviruses belong to Mitoviridae family and consist of positive single-stranded RNA genomes replicating exclusively in host mitochondria.
Dario Di Silvestre, Giulia Passignani, Rossana Rossi, Marina Ciuffo, Massimo Turina, Gianpiero Vigani, Pier Luigi Mauri   +6 more
doaj   +1 more source

A Note on the Consequences of a Hot Mitochondrion: Some Recent Developments and Open Questions

Біофізичний вісник, 2020
Background: Chrétien and co-workers (PLOS Biology. 2018;16(1):e2003992) recently suggested that the mitochondrion might possibly be hotter than its surrounding (by as much as 10°C).
Peyman Fahimi, Mohamed A. Nasr, Lazaro M. A. Castanedo, Youji Cheng, Cyrus Ahmady Toussi, Cherif Farid Matta   +5 more
doaj   +1 more source