Results 101 to 110 of about 382,530 (347)

Mitochondria directly influence fertilisation outcome in the pig [PDF]

, 2006
The mitochondrion is explicitly involved in cytoplasmic regulation and is the cell's major generator of ATP. Our aim was to determine whether mitochondria alone could influence fertilisation outcome.
Abeydeera, Alves, Anderson, Barritt, Barritt, Barritt, Blok, Brenner, Cetica, Clayton, Cohen, Cohen, Cran, de Loos, Downs, Dumollard, Eisen, Emma C Spikings, Findlay, Fong, Hue, Jansen, Justin C St John, King, Koo, Krakauer, Larsson, Larsson, Li, Lin, Liu, Mach  ty, Marchington, Mariana Freitas, Marinos, McConnell, Michaels, Moyes, Park, Pik  , Poulton, Raghu, Reynier, Roca, Sathananthan, Shahinaz H El Shourbagy, Shea, Spelbrink, St John, St John, St John, St John, St. John, Stojkovic, Sun, Tessa, Tian, Trimarchi, Ursing, Van Blerkom, Van Blerkom, Van Blerkom, Wakayama, Wallace, Wilmut, Zamzami, Zernicka-Goetz   +66 more
core   +2 more sources

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Sequence and phylogenetic analysis of the mitochondrial genome for the Northern Anchovy, Engraulis mordax (Engraulidae: Clupeiformes)

Mitochondrial DNA. Part B. Resources, 2019
The northern anchovy, Engraulis mordax, is a small planktivorous fish from the northeastern Pacific Ocean that is an important forage for fishes, birds, and marine mammals, and is also the target of a commercial fishery.
Olivia H. Lewis, Sean C. Lema
doaj   +1 more source

The balance between fumarate and malate plays an important role in plant development and postharvest quality in tomato fruit [PDF]

, 2018
Organic acids, produced as intermediates of the tricarboxylic cycle, play a crucial role in the plant primary metabolism and are considered as being ones of the most important quality traits in edible fruits.
Fernie, Alisdair R, Jimenez, Lidia, Martinez-Ferri, Elsa, Osorio-Algar, Sonia, Pott, Delphine, Vallarino, José G.   +5 more
core  

A Peroxisomal Lon Protease and Peroxisome Degradation by Autophagy Play Key Roles in Vitality of Hansenula polymorpha Cells [PDF]

, 2007
In eukaryote cells various mechanisms exist that are responsible for the removal of non-functional proteins. Here we show that in the yeast Hansenula polymorpha (H.
Bener Aksam, Eda, Jourdan, Stefanie, Kiel, Jan A.K.W., Klei, Ida J. van der, Koek, Anne, Veenhuis, Marten   +5 more
core   +2 more sources

Electrical pulse stimulation reflecting the episodic nature of real‐life exercise modulates metabolic and secretory profile of primary human myotubes

FEBS Open Bio, EarlyView.
Here, we introduced an intermittent electrical stimulation protocol mimicking the episodic nature of real‐life exercise in vitro by alternating low‐ and high‐frequency stimulation. In comparison with widely used continuous stimulation, it enhanced the rate of glucose and fatty acid oxidation, but not the myokine release.
Klára Gabrišová, Tímea Kurdiová, Daria Barkova, Natália Pálešová, Jana Babulicová, Silvia Tyčiaková, Marta Novotová, Mária Balážová, Miroslav Sabo, Václav Pustka, Jozef Ukropec, Barbara Ukropcová   +11 more
wiley   +1 more source

Oma1 Links Mitochondrial Protein Quality Control and TOR Signaling To Modulate Physiological Plasticity and Cellular Stress Responses [PDF]

, 2016
ACKNOWLEDGMENTS We thank Dennis Winge (University of Utah) and the members of the Khalimonchuk laboratory for critical comments. We also thank Christoph Schuller (University of Natural Resources, Austria) and Paul Herman (Ohio State University) for ...
Barrientos, Antoni, Bohovych, Iryna, Brown, Alistair J.P., Christianson, Sara, Fangman, Teresa, Kastora, Stavroula, Khalimonchuk, Oleh, Kim, Heejeong, Lee, Jaekwon, Topil, Danelle, Zhou, You J.   +10 more
core   +2 more sources

The impact of Hnrnpl deficiency on transcriptional patterns of developing muscle cells

FEBS Open Bio, EarlyView.
We performed nanopore whole‐transcriptome sequencing comparing RNA from Hnrnpl‐knockdown versus control C2C12 myoblasts to investigate the contributions of Hnrnpl to muscle development. Our results indicate that Hnrnpl regulates the expression of genes involved with Notch signaling and skeletal muscle, particularly splicing patterns of specific muscle ...
Hannah R. Littel, Mekala Gunasekaran, Audrey L. Daugherty, Natalya M. Wells, Johnnie Turner, Christine C. Bruels, Christina A. Pacak, Isabelle Draper, Peter B. Kang   +8 more
wiley   +1 more source

How proteins are transported into mitochondria [PDF]

, 1981
Most mitochondrial polypeptides are synthesized outside the organelle as precursors which are usually larger than the ‘mature’ polypeptides found within mitochondria.
Neupert, Walter, Schatz, Gottfried
core   +1 more source

Short‐term actions of epigalocatechin‐3‐gallate in the liver: a mechanistic insight into hypoglycemic and potential toxic effects

FEBS Open Bio, EarlyView.
Epigallocatechin‐3‐gallate (EGCG) acutely inhibited gluconeogenesis and enhanced glycolysis, glycogenolysis, and fatty acid oxidation in perfused rat livers. Mechanistic assays revealed mitochondrial uncoupling, inhibition of pyruvate carboxylation and glucose‐6‐phosphatase, shift of NADH/NAD+ ratios toward oxidation, and loss of membrane integrity ...
Carla Indianara Bonetti, Bruna Lopes Correia, Francielle Cristina Nakamura Manicardi, Nairana Mithieli de Queiroz Eskuarek Melo, Vanesa de Oliveira Pateis, Jurandir Fernando Comar, Anacharis Babeto de Sá‐Nakanishi, Adelar Bracht, Lívia Bracht   +8 more
wiley   +1 more source