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The Cardiac Mitochondrion: Nexus of Stress
Annual Review of Physiology, 2010The emergence of mitochondria as critical regulators of cardiac myocyte survival and death has revolutionized the field of cardiac biology. Indeed, it is now well recognized that mitochondrial dysfunction plays a crucial role in the pathogenesis of multiple cardiac diseases.
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The Mitochondrion: Is It Central to Apoptosis?
Science, 2001Despite a tide of data suggesting that mitochondria are primary in triggering programmed cell death, a small minority of researchers argues that the primary apoptosis signals route directly to enzymes called caspases without first involving the mitochondria.
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