Results 231 to 240 of about 382,530 (347)

AI-directed voxel extraction and volume EM identify intrusions as sites of mitochondrial contact. [PDF]

J Cell Biol
Padman BS, Lindblom RSJ, Lazarou M.
europepmc   +1 more source

Multiple trans-splicing events are required to produce a mature nad1 transcript in a plant mitochondrion. [PDF]

, 1991
Patricia L. Conklin, Robin K. Wilson, Maureen R. Hanson   +2 more
openalex   +1 more source

Exploring Functionally Enhanced BLP‐Trained Macrophage Subpopulations in S. Aureus Infection: Underlying Mechanisms and Therapeutic Significance

Advanced Science, EarlyView.
BLP‐trained macrophages show augmented resistance to infection, but their mechanisms remain unclear. scRNA‐seq identified 13 BMDM subsets, with two novel anti‐inflammatory/antibacterial subpopulations (C5/C7) emerging post‐BLP training. BLP training activates NRF2, attenuates oxidative stress/ferroptosis, and boosts glycolysis/OXPHOS. Adoptive transfer
Yantong Wan, Yinghao Hong, Xiangjun Ji, Jing Xiang, Jinxi Liu, Lixin Liang, Meng Ren, Wenhan Chen, Tengfei Xu, Zhijie Li, Tieliu Shi, Yong Jiang, Huaping Liang, Jinghua Liu   +13 more
wiley   +1 more source

From Ancient Philosophy to Endosymbiotic Theory: The Bacterial Origin and Key Role of Mitochondria in Immune Responses. [PDF]

Microorganisms
Mpakosi A, Kaliouli-Antonopoulou C, Cholevas V, Cholevas S, Tzouvelekis I, Mironidou-Tzouveleki M, Tsantes EA, Tsakri D, Vlachaki M, Baliou S, Ioannou P, Sokou R, Bonovas S, Tsantes AG.   +13 more
europepmc   +1 more source

Obesity‐Associated TRIM15 Promotes the Proliferation of Esophageal Adenocarcinoma Through the YY2/FOXRED1 Axis

Advanced Science, EarlyView.
The study identifies TRIM15 as a key driver in the development of obesity‐associated esophageal adenocarcinoma (EAC). Mechanistically, TRIM15 degrades YY2 through the proteasome pathway, suppressing FOXRED1 transcription and ultimately accelerating tumor proliferation.
Haohui Wang, Chong Yang, Dayuan Luo, Pingting Liu, Zhen Zeng, Weilin Peng, Dongzi Peng, Hao Su, Xiaoxiong Xiao, Haiqin Wang, Xin Jin   +10 more
wiley   +1 more source

Zero-shot segmentation using embeddings from a protein language model identifies functional regions in the human proteome. [PDF]

PLoS Comput Biol
Sangster AG, Dufault C, Qu H, Le D, Forman-Kay JD, Moses AM.   +5 more
europepmc   +1 more source

Lnc‐HZ05 Suppresses Trophoblast Cell Migrasome Formation by Disrupting TGFβ2 Pathway in Unexplained Recurrent Miscarriage

Advanced Science, EarlyView.
TGFβ2 signaling‐mediated migration/invasion and migrasome formation are suppressed in recurrent miscarriage (RM) versus healthy control villous tissues and are negatively associated with unexplained RM. In mechanism, TGFβ2 promotes trophoblast cell migration/invasion and migrasome formation, all of which are suppressed by lnc‐HZ05. In details, lnc‐HZ05
Weina Chen, Ying Zhang, Zimeng Zhao, Yang Yang, Geng Guo, Yi Sun, Tao Zhang, Zhihong Zhang, Liqin Zeng, Wenxin Huang, Qingjun Shen, Ruining Han, Zhaohui He, Depeng Zhao, Huidong Zhang   +14 more
wiley   +1 more source

Metformin Restores Mitochondrial Function and Neurogenesis in POLG Patient‐Derived Brain Organoids

Advanced Science, EarlyView.
Patient‐derived POLG‐mutant cortical organoids reveal neuronal subtype‐specific mitochondrial and synaptic defects, with dopaminergic neurons most affected. Metformin treatment restores neuronal identity, mitochondrial function, and excitability, increased mtDNA maintenance, and reprogrammed metabolism via TCA and redox pathways.
Zhuoyuan Zhang, Tsering Yangzom, Ning Lu, Shenglong Deng, Xianglu Xiao, Guang Yang, Kristina Xiao Liang   +6 more
wiley   +1 more source

Draft genome sequence of <i>Prototheca bovis</i> strain P18 isolated from cattle in Japan. [PDF]

Microbiol Resour Announc
Akiba M, Sekizuka T, Yasutomi I, Fujii Y, Uchida I.   +4 more
europepmc   +1 more source

Enhanced Cardiac Akt/Protein Kinase B Signaling Contributes to Pathological Cardiac Hypertrophy in Part by Impairing Mitochondrial Function via Transcriptional Repression of Mitochondrion-Targeted Nuclear Genes [PDF]

, 2014
Adam R. Wende, Brian T. O’Neill, Heiko Bugger, Christian Riehle, Joseph Tuinei, Jonathan Buchanan, Kensuke Tsushima, Li Wang, Pilar Caro, Aili Guo, Crystal Sloan, Bum Jun Kim, Xiaohui Wang, Renata O. Pereira, Mark A. McCrory, Brenna G. Nye, Gloria A. Benavides, Victor Darley‐Usmar, Tetsuo Shioi, Bart C. Weimer, E. Dale Abel   +20 more
openalex   +1 more source