Results 241 to 250 of about 328,766 (309)

Automated cell structure extraction for 3D electron microscopy by deep learning. [PDF]

Sci Rep
Kousaka J, Iwane AH, Togashi Y.
europepmc   +1 more source

Polyhalogenated Carbazole Impairs Dopaminergic Neurons through Dysregulation of Liquid–Liquid Phase Separation in Caenorhabditis elegans

Advanced Science, EarlyView.
Polyhalogenated carbazoles (PHCZ), persistent environmental contaminants, preferentially accumulate in neuronal tissues. Studies using Caenorhabditis elegans and human neuronal cell lines reveal that PHCZ induce dopaminergic neurodegeneration by promoting liquid–liquid phase separation of α‐synuclein, reducing condensate fluidity, impairing ...
Yuhang Luo, Hongbo Xu, Pei Peng, Xinhe Lu, Qian Zhou, Ziqing Gao, Cheng Tang, Hongyan Yin, Ying Cai, Gaga Mahai, Zhiqiang Zhu, Zuojun Liu, Hanzeng Li, Shunqing Xu   +13 more
wiley   +1 more source

Single molecule spectrum dynamics imaging with 3D target-locking tracking. [PDF]

Nat Commun
Sha H, Wu Y, Zhang Y, Liu R, Feng X, Li H, Wang Z, Zhang X, Hou S.   +8 more
europepmc   +1 more source

GLS1‐RNA Polymerase II Axis Mediates Glutamine‐Dependent Hepatoprotective Effects on Alcoholic Liver Disease in High‐Protein Diets

Advanced Science, EarlyView.
GLS1 interacts with RNA polymerase II subunits, ROLR2H and POLR2E, resulting in significant suppression of RNA polymerase II activity. Importantly, the investigation demonstrates that high‐protein diets, particularly glutamine, exert protective effects against alcoholic fatty liver through GLS1‐RNA polymerase II axis.
Wenbiao Wu, Haowen Jiang, Yichang Liu, Chang Peng, Hanlin Wang, Wenhua Yang, Zan Lyu, Yan Sun, Huan Ma, Hongyu Gu, Weijuan Kan, Liya Jing, Tiancheng Dong, Chunmei Xia, Saifei Lei, Rui Wu, Jinlong Li, Jia Li   +17 more
wiley   +1 more source

Sanggenol L Enhances Temozolomide Drug Sensitivity by Inhibiting Mitophagy and Inducing Apoptosis Through the Regulation of the TRIM16‐OPTN Axis in Glioblastoma

Advanced Science, EarlyView.
Sanggenol L, a flavonoid from mulberry, enhances glioblastoma sensitivity to temozolomide by inhibiting mitophagy and inducing apoptosis through TRIM16‐mediated OPTN degradation. In animal studies, liposomal delivery of Sanggenol L significantly improves the efficacy of its combination with TMZ, providing new insights into glioblastoma treatment ...
Hongbo Chang, Jianbing Hou, Xin Hu, Nana Hou, Minghao Xu, Yi Du, Jingyang Xu, Yongzhao Wang, Zhuohao Xie, Junbo Shi, Yundong Zhang, Hongjuan Cui   +11 more
wiley   +1 more source

Phosphatase UBLCP1 is required for the growth, virulence and mitochondrial integrity of Toxoplasma gondii. [PDF]

Parasit Vectors
Sheng K, Song K, Yang Y, Wu H, Du Z, Chen X, Yang Y, Ma G, Du A.   +8 more
europepmc   +1 more source

Deficiency of SCAMP5 Triggers Pancreatic β‐Cell Secretory Dysfunction and Apoptosis

Advanced Science, EarlyView.
This study demonstrates that hyperglycemia in diabetes activates ChREBP, which epigenetically represses SCAMP5 expression in pancreatic β‐cells. This SCAMP5 deficiency impairs insulin secretion by downregulating the calcium channel CaV1.2. Furthermore, reduced SCAMP5 triggers β‐cell apoptosis by stabilizing VDAC1 and enhancing its interaction with Bax,
Yingqi Zhang, Donglan Tang, Chenxi Yang, Chao Lin, Yingyue Yuan, Meiying He, Yiying Chen, Zhuo Mao, Ying Ying, Xiaosong Ma, Xiangchen Kong   +10 more
wiley   +1 more source

Correction: Post-translational modifications in sepsis-induced acute kidney injury: mechanisms and perspectives. [PDF]

Front Pharmacol
Song L, Jiang W, Liu K, Wang J, Gong W, Yu J, Zheng R.   +6 more
europepmc   +1 more source

FOXQ1 Regulates Brain Endothelial Mitochondrial Function by Orchestrating Calcium Signaling and Cristae Morphology

Advanced Science, EarlyView.
FOXQ1 emerges as a master transcriptional regulator of brain endothelial metabolism, orchestrating mitochondrial function through dual control of calcium signaling and cristae organization. This study reveals that brain endothelial cells rely on oxidative phosphorylation rather than glycolysis alone, challenging the current metabolic paradigm and ...
Wenzheng Zou, Yuqing Lv, Lin Li, Shukui Zhang, Jiaqi Liang, Chengchao Wu, Enyu Huang, Jianwei Jiao, Jingjing Zhang   +8 more
wiley   +1 more source

Structural diversity and phylogenomic insights from the mitochondrial genomes of two <i>populus</i> species from the Qinghai-Tibet Plateau. [PDF]

Front Plant Sci
Huang JL, Shi YJ, Tian FF, Mi JX, Zhang F, Zhou SX, Wan XQ, Huang CD.   +7 more
europepmc   +1 more source