Results 21 to 30 of about 10,890 (218)
When should MERRF (myoclonus epilepsy associated with ragged-red fibers) be the diagnosis?
Arquivos de Neuro-Psiquiatria, 2014 Myoclonic epilepsy associated with ragged red fibers (MERRF) is a rare mitochondrial disorder. Diagnostic criteria for MERRF include typical manifestations of the disease: myoclonus, generalized epilepsy, cerebellar ataxia and ragged red fibers (RRF) on ...
Paulo José Lorenzoni +4 more
doaj +1 more source
Apunts: Educación Física y Deportes, 2013 Este es un estudio personal altamente subjetivo sobre la investigación llevada a cabo durante los últimos 50 años que documenta los fenómenos y los mecanismos de la plasticidad del tejido muscular esquelético.
Hans Hoppeler
doaj +1 more source
EFECTO DEL LINALOOL SOBRE LA BIOENERGÉTICA DE MITOCONDRIAS DE HÍGADO DE RATA
Vitae, 2015 Antecedentes: El linalool (2,6-dimetil-2,7-octadien-6-ol) es un monoterpeno presente en más de 200 tipos de plantas, y constituye el componente mayoritario de varios aceites esenciales.
Yenny BUENO-DUARTE +1 more
doaj +1 more source
Proteostasis of organelles in aging and disease
The FEBS Journal, EarlyView.Cells rely on regulated proteostasis mechanisms to keep their internal compartments functioning properly. When these mechanisms fail, damaged proteins accumulate, disrupting organelles, such as the nucleus, mitochondria, endoplasmic reticulum, Golgi, and lysosomes, as well as membraneless organelles, such as stress granules, processing bodies, the ...
Yara Nabawi +5 more
wiley +1 more source
The dynamic mitochondria-nuclear redistribution of FKBP51 during the process of adipocyte differentiation is regulated by PKA [PDF]
, 2013 Los glucocorticoides tienen un papel central en la adipogénesis, por su unión al receptor RG cito-plasmático formando parte de un heterocomplejo también integrado por una inmunofilina (INM) de alto peso molecular, FKBP51 o FKBP52.
Charó, Nancy Lorena +3 more
core +1 more source
Molecular Oncology, Volume 20, Issue 5, Page 1253-1269, May 2026.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Manejo del paciente con enfermedades mitocondriales [PDF]
, 2019 Las enfermedades mitocondriales son un grupo de mutaciones englobadas dentro de las denominadas “enfermedades raras”. Son producidas por alteraciones en el mtDNA, que generan un déficit en la síntesis de ATP; la energía básica para el correcto ...
García Díez, Jorge
core
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, Volume 20, Issue 5, Page 1202-1219, May 2026.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Effect of Vitamin E on Oocytes Apoptosis in nicotine-treated Mice [PDF]
, 2012 Objective(s): Cigarette and nicotine enhances embryogenesis, fertility, pregnancy loss and ultrastructure alterations of oocyte. This study was performed to determine the effect of daily supplementation of vitamin E on oocytes apoptosis in nicotine ...
Asadi, E. +2 more
core +1 more source
SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1
FEBS Open Bio, Volume 16, Issue 5, Page 870-884, May 2026.Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl +13 more
wiley +1 more source