Results 31 to 40 of about 10,890 (218)
The theory of oxidative stress as a direct cause of cell aging
Medisur, 2018 The loss of functional capacities, aging and death are inherent to all living matter due to metabolism and other factors causing the formation of substances which damage irreversibly cell structure components.
Milagros Lisset León Regal +5 more
doaj +2 more sources
Enfermedades mitocondriales. Plan de cuidados estandarizado en pacientes con síndrome MELAS [PDF]
, 2017 Las enfermedades mitocondriales son enfermedades genéticas causadas por mutaciones en el ácido desoxirribonucleico de la mitocondria (mtDNA). Este orgánulo es el encargado de la obtención de energía celular.
Fernández Pérez, David
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FEBS Open Bio, Volume 16, Issue 5, Page 885-905, May 2026.Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid +3 more
wiley +1 more source
Caracterización de cíbridos trasmitocondriais [PDF]
, 2014 Introducción: Los cíbridos se obtuvieron a partir de líneas celulares inmortales desprovistas de ADN mitocondrial (ADNmt) (línea celular Rho-0) con plaquetas que portan el ADNmt.
Vidal Bretal, Beatriz
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The role of lipid metabolism in neuronal senescence
FEBS Open Bio, Volume 16, Issue 5, Page 857-869, May 2026.Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari +2 more
wiley +1 more source
Efectos del estrés oxidativo en la retina [PDF]
, 2019 La absorción de la luz por las células de la retina produce reacciones fotoquímicas que dan lugar a las especies reactivas de oxígeno y a radicales libres que crean un nivel de estrés oxidativo alto. Se planteó este trabajo de revisión bibliográfica para
López Tejedor, Agustín
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Molecular Oncology, Volume 20, Issue 4, Page 1061-1073, April 2026.Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard +5 more
wiley +1 more source
Nuevas terapias para la neuropatía óptica hereditaria de Leber [PDF]
, 2016 La neuropatía óptica hereditaria de Leber es una enfermedad rara ligada al ADN mitocondrial, de manera que es transmitida verticalmente de madres a hijos.
Lora Domínguez, Paula Carla
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The FEBS Journal, Volume 293, Issue 7, Page 2086-2097, April 2026.Cells rely on mitochondria and peroxisomes to trigger antiviral defenses via the protein MAVS. This manuscript demonstrates that the robust production of antiviral effectors resulting from MAVS activation at peroxisomes is faster than at mitochondria due to a swifter oligomerization of this protein at peroxisomal membranes. These results underscore the
Bruno Ramos +4 more
wiley +1 more source
The FEBS Journal, Volume 293, Issue 8, Page 2454-2477, April 2026.Dietary and genetic stress trigger different routes to heart failure. In mice, a carbohydrate‐free high‐fat diet caused mitochondrial dysfunction and impaired energy production with preserved pumping function, while genetic obesity led to heart enlargement, fibrosis, and reduced function.
Christiane Ott +9 more
wiley +1 more source