Results 31 to 40 of about 1,602 (210)
Generación de un modelo de ratón Knock-in para analizar la actividad supresora tumoral de la proteína p53 localizada en la mitocondria [PDF]
, 2015 [ES]P53 es una proteína implicada en muchos procesos celulares. De todas sus funciones la más estudiada es la de supresión tumoral. En presencia de estrés celular, p53 se activa y evita la transformación maligna de las células, provocando la muerte ...
Parrilla Monge, Laura
core +1 more source
Las enfermedades raras en las patologías neurometabólicas
Arbor: Ciencia, Pensamiento y Cultura, 2018 Las miopatías metabólicas son un grupo de trastornos genéticos que disminuyen la capacidad del músculo esquelético para utilizar sustratos energéticos y sintetizar ATP.
Julio Montoya +3 more
doaj +1 more source
Lipids, EarlyView.The experimental design and the exometabolomic findings obtained by 1H‐NMR analysis of conditioned media from subcutaneous (SAT) and epididymal adipose tissue (EAT) explants of control and obese mice supplemented with chia oil (1.5% (w/w)). Following 8 weeks of control or high‐fat diet and 5 weeks of chia oil supplementation, SAT and EAT explants were ...
Gilson Costa dos Santos Jr +5 more
wiley +1 more source
, 2012 La Mitocondria desempeña un papel clave en la activación de la apoptosis en las células de mamíferos. Los miembros de la familia de proteínas de Bcl-2 regulan la liberación de proteínas como Cit c del espacio situado entre la membrana interna y la ...
Ortiz Melón, José Miguel +1 more
core +1 more source
Proteostasis of organelles in aging and disease
The FEBS Journal, EarlyView.Cells rely on regulated proteostasis mechanisms to keep their internal compartments functioning properly. When these mechanisms fail, damaged proteins accumulate, disrupting organelles, such as the nucleus, mitochondria, endoplasmic reticulum, Golgi, and lysosomes, as well as membraneless organelles, such as stress granules, processing bodies, the ...
Yara Nabawi +5 more
wiley +1 more source
Estudio de la función de FASTKD3 en la mitocondria [PDF]
, 2017 Tesis Doctoral presentada por Rebeca Torres Merino para optar al grado de Doctora por la Universidad de Valladolid, Facultad de Medicina: Dpto.
Torres-Merino, Rebeca
core +3 more sources
FEBS Open Bio, Volume 16, Issue 7, Page 1387-1399, July 2026.We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa +2 more
wiley +1 more source
The theory of oxidative stress as a direct cause of cell aging
Medisur, 2018 The loss of functional capacities, aging and death are inherent to all living matter due to metabolism and other factors causing the formation of substances which damage irreversibly cell structure components.
Milagros Lisset León Regal +5 more
doaj +2 more sources
FEBS Letters, Volume 600, Issue 12, Page 1782-1800, June 2026.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
FEBS Letters, Volume 600, Issue 12, Page 1699-1716, June 2026.Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas +3 more
wiley +1 more source