Results 41 to 50 of about 2,320 (200)

ER proteostasis meets mitochondrial function: contact sites as hubs of communication and therapeutic targets

The FEBS Journal, Volume 293, Issue 18, Page 5585-5599, September 2026.
Proteostasis ensures proper protein folding, modification, and degradation, while its impairment triggers ER stress. Chronic ER stress and maladaptive UPR via the CHOP–ERO1 axis remodel ERMCs, altering calcium signaling and mitochondrial metabolism.
Giorgia Maria Renna, Alessandro Cherubini, Ersilia Varone, Serena Germani, Alice Marrazza, Ester Zito   +5 more
wiley   +1 more source

Proteostasis of organelles in aging and disease

The FEBS Journal, Volume 293, Issue 18, Page 5600-5626, September 2026.
Cells rely on regulated proteostasis mechanisms to keep their internal compartments functioning properly. When these mechanisms fail, damaged proteins accumulate, disrupting organelles, such as the nucleus, mitochondria, endoplasmic reticulum, Golgi, and lysosomes, as well as membraneless organelles, such as stress granules, processing bodies, the ...
Yara Nabawi, Cansu Doğan, Dunja Petrović, Gülce Perçin, Seda Koyuncu, David Vilchez   +5 more
wiley   +1 more source

GCN2 in proteostasis: structural logic, signalling networks and disease

The FEBS Journal, Volume 293, Issue 18, Page 5627-5644, September 2026.
Threats to protein synthesis activate the kinase GCN2, initiating the integrated stress response (ISR). GCN2 is triggered by stalled ribosomes and uncharged tRNAs, which accumulate when amino acids are scarce. The ISR adjusts cellular physiology by promoting redox balance, protein quality control, and mitochondrial optimisation.
JiaYi Zhu, Stefan J. Marciniak
wiley   +1 more source

Disruption of iron metabolism resulting from Dmt1/Slc11a2 deficiency compromises Notch protein degradation and transcriptional activation

The FEBS Journal, Volume 293, Issue 17, Page 5383-5395, September 2026.
Divalent metal transporter 1 (Dmt1) maintains iron homeostasis and lysosomal proteostasis required for physiological Notch receptor–ligand signaling. Dmt1 loss lowers iron storage capacity (ferritin), increasing intracellular Fe2+, driving ROS and lipid peroxidation, and leading to lysosomal/mitochondrial dysfunction.
Rui Zhang, Somaieh Ahmadian, Jolanda Piepers, Florian Bock, Tom Keulers, Marc A. Vooijs   +5 more
wiley   +1 more source

Mitochondrial ultrastructural and atpase changes during the life cycle of Ascaris Suum

Memorias do Instituto Oswaldo Cruz, 1982
Ultrastructural morphology and ATPase specific activities of mitochondria isolated from 1-celled fertilized egg, 10-day embryo, 21-day infective larvae and adult body wall muscle of Ascaris suum and rat liver were determined and compared.
G. E. Rodrick, S. D. Long, W. A. Sodeman Junior, D. L. Smith   +3 more
doaj   +1 more source

MITOCONDRIA. La energía de la vida

Diagnostico
Mencionan los autores en el Prefacio: “Hace aproximadamente 2000 millones de años existía en la Tierra una bacteria aeróbica que flotaba en el océano y era capaz de vivir en presencia de oxígeno tóxico e, incluso, de usarlo para obtener energía. En un momento dado de la historia, esa bacteria fue engullida por otra célula, una célula nucleada y ...
Carlos Alvarado-Ortiz Ureta, Teresa Blanco De Alvarado-Ortiz, Luciana De la Fuente-Carmelino   +2 more
openaire   +1 more source

Hsp70 diversification and repurposing across the tree of life: Lessons from the evolutionary and mechanistic trajectory of the Hsp70–Hsp110 chaperone system

The FEBS Journal, Volume 293, Issue 18, Page 5541-5557, September 2026.
Evolutionary and mechanistic divergence in the Hsp70–Hsp110 chaperone system. Prokaryotic Hsp70s probably diversified into multiple orthologues that cooperated with co‐chaperones such as JDPs and NEF, forming increasingly complex proteostasis networks.
Pierre Goloubinoff, Paolo De Los Rios, Mathieu E. Rebeaud   +2 more
wiley   +1 more source

Bases moleculares de las enfermedades mitocondriales Molecular basis of mitochondrial diseases

Medisan, 2012
Las mitocondrias son orgánulos subcelulares que tienen como misión principal la producción de energía, los cuales contienen su propio sistema genético que codifica un número pequeño de proteínas que forman parte del sistema de fosforilación oxidativa. En
Aglais Arredondo Falagán, Gleymis Venet Cadet, Olivia Román Guerra, Eglis Yanet Ramírez Delgado   +3 more
doaj  

Mitochondrial transfer in acute myeloid leukaemia and multiple myeloma: Mechanisms, consequences and potential therapeutic opportunities

The FEBS Journal, Volume 293, Issue 17, Page 5107-5120, September 2026.
Mitochondria can be transferred from bone marrow cells to cancer cells in acute myeloid leukaemia and multiple myeloma, boosting tumour energy production, growth, and drug resistance. This review highlights key transfer mechanisms and shows how targeting mitochondrial movement and dynamics may offer new therapeutic strategies to limit cancer ...
Ebubechukwu Nwarunma, Mark T. S. Williams   +1 more
wiley   +1 more source

Stimulating proteasomal degradation in human proteinopathies

The FEBS Journal, Volume 293, Issue 18, Page 5514-5540, September 2026.
The proteasome mediates the degradation of a wide range of proteins. Boosting proteasomal degradation may be beneficial in several disease contexts and can be achieved either by modulating proteasome activity or by improving substrate delivery. Proteasome activity can be enhanced by increasing proteasome abundance, inducing constitutive gate opening ...
Maria E. Gierisch, Enrica Barchi, Nico P. Dantuma   +2 more
wiley   +1 more source