Results 41 to 50 of about 1,602 (210)

The pyruvate generator is a common phenomenon in mitochondria from different rat and mouse brain regions

FEBS Letters, Volume 600, Issue 12, Page 1770-1781, June 2026.
The pyruvate generator, which causes activation of respiration by extra‐mitochondrial Ca2+, is also present and functional in rat brainstem mitochondria, as it is in other brain regions. This finding is confirmed by experiments with a fully reconstituted malate–aspartate shuttle (MAS).
Grazyna Debska‐Vielhaber, Niki Karavasili, Matthias Kunz, Zemfira Gizatullina, Timur Gainutdinov, Stefan Vielhaber, Wolfram S. Kunz, Frank N. Gellerich   +7 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, Volume 20, Issue 6, Page 1398-1419, June 2026.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, Volume 20, Issue 6, Page 1453-1472, June 2026.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Rol de la mitocondria en la Sepsis [PDF]

, 2020
The mitochondria is a complex organization, its main function is the production of energy in the form of ATP, essential for life. Semi-autonomous since it has mtDNA capable of producing some main respiratory chain proteins.
Jara, Fernando, Vélez, Pablo, Velarde, Gustavo Carlos, Montalvo, Mario, Aguayo Moscoso, Santiago Xavier, Vélez, Jorge Luis   +5 more
core  

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, Volume 16, Issue 6, Page 1087-1101, June 2026.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Mitochondrial ultrastructural and atpase changes during the life cycle of Ascaris Suum

Memorias do Instituto Oswaldo Cruz, 1982
Ultrastructural morphology and ATPase specific activities of mitochondria isolated from 1-celled fertilized egg, 10-day embryo, 21-day infective larvae and adult body wall muscle of Ascaris suum and rat liver were determined and compared.
G. E. Rodrick, S. D. Long, W. A. Sodeman Junior, D. L. Smith   +3 more
doaj   +1 more source

MITOCONDRIA. La energía de la vida

Diagnostico
Mencionan los autores en el Prefacio: “Hace aproximadamente 2000 millones de años existía en la Tierra una bacteria aeróbica que flotaba en el océano y era capaz de vivir en presencia de oxígeno tóxico e, incluso, de usarlo para obtener energía. En un momento dado de la historia, esa bacteria fue engullida por otra célula, una célula nucleada y ...
Carlos Alvarado-Ortiz Ureta, Teresa Blanco De Alvarado-Ortiz, Luciana De la Fuente-Carmelino   +2 more
openaire   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, Volume 16, Issue 6, Page 1115-1131, June 2026.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Función de la oncoproteína GOLPH3 en la interfase aparato de Golgi-mitocondria [PDF]

, 2023
Doctor en Biología Celular y BiomedicinaDentro de la célula existen diversas formas de comunicación, dentro de las cuales se encuentran el tráfico vesicular o a través de sitios de contactos entre el mismo organelo o con otro organelo diferente. Para que
Meléndez Polanco, Catalina Andrea
core  

Bases moleculares de las enfermedades mitocondriales Molecular basis of mitochondrial diseases

Medisan, 2012
Las mitocondrias son orgánulos subcelulares que tienen como misión principal la producción de energía, los cuales contienen su propio sistema genético que codifica un número pequeño de proteínas que forman parte del sistema de fosforilación oxidativa. En
Aglais Arredondo Falagán, Gleymis Venet Cadet, Olivia Román Guerra, Eglis Yanet Ramírez Delgado   +3 more
doaj