Results 61 to 70 of about 10,890 (218)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, Volume 20, Issue 2, Page 428-446, February 2026.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Human FASTK preferentially binds single‐stranded and G‐rich RNA

The FEBS Journal, Volume 293, Issue 3, Page 729-748, February 2026.
Although FASTK is known to play a role in mRNA biology, the mechanism through which it recognizes RNA has yet to be unraveled. Here, we used purified human FASTK to characterize its RNA‐binding properties in vitro. We found that FASTK prefers ssRNA oligonucleotides containing guanines with the potential to form G‐quadruplexes and binds robustly to any ...
Daria M. Dawidziak, Dawid A. Dzadz, Mikołaj I. Kuska, Madhuri Kanavalli, Maria M. Klimecka, Matthew Merski, Katarzyna J. Bandyra, Maria W. Górna   +7 more
wiley   +1 more source

Metabolismo dos lípidos [PDF]

, 2011
Titulación: Grao en Veterinaria -- Materia: BioquímicaEsta unidade didáctica, Metabolismo dos lípidos, englóbase dentro da materia Bioquímica que se imparte na titulación de Grao en Veterinaria.
Ibarguren Arizeta, María de Izaskun
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Transglutaminase‐mediated cytokeratin modifications implicated in bile‐acid‐induced hepatocyte death

The FEBS Journal, Volume 293, Issue 4, Page 1089-1105, February 2026.
Cholestasis and bile‐acid exposure enhance expression and activity of protein crosslinking enzymes TG1 and TG2 in hepatocytes. Substrate proteins were identified by mass spectrometry using biotin‐labeled peptides (pepK5/pepT26) or amine donor (biotinylated pentylamine; BPA). Crosslinking‐induced aggregation and fragmentation of keratin 18 and 8 (K18/K8)
Hideki Tatsukawa, Haruka Nakagawa, Chin Mun Yee, Keiko Kuwata, Kiyotaka Hitomi   +4 more
wiley   +1 more source

Modulación de la señal de calcio y los receptores de IP3 en neuronas de hipocampo envejecidas in vitro y tratadas con oligómeros del péptido amiloide [PDF]

, 2019
El envejecimiento y las enfermedades neurodegenerativas asociadas al mismo son actualmente un reto social, debido a su incipiente aumento en los países desarrollados.
López Vázquez, Sara
core   +1 more source

Label‐free imaging of intracellular structures in living mammalian cells via external apodization phase‐contrast microscopy

The FEBS Journal, Volume 293, Issue 4, Page 1127-1149, February 2026.
Advanced techniques to visualize the spatiotemporal functionality of biomolecules are essential for elucidating mechanisms governing cellular behavior. External apodization phase‐contrast (ExAPC) microscopy enables label‐free visualization of diverse intracellular structures in living mammalian cells. By enhancing phase‐contrast imaging through optical
Hiroshi Ohno, Takenori Nishimura, Kenta Kainoh, Yoshitaka Ohashi, Naoko Onodera, Mayuko Kano, Lay Nurhana Sari, Masato Masuda, Yoshiaki Tamura, Teppei Nishino, Yusuke Hayashi, Yusuke Yamamoto, Shin‐Ichiro Takahashi, Yuta Mishima, Yosuke Yoneyama, Yoshinori Takeuchi, Motohiro Sekiya, Takashi Matsuzaka, Takafumi Miyamoto, Hitoshi Shimano   +19 more
wiley   +1 more source

Immunology and Oxidative Stress in Multiple Sclerosis: Clinical and Basic Approach

Clinical and Developmental Immunology, 2013
Multiple sclerosis (MS) exhibits many of the hallmarks of an inflammatory autoimmune disorder including breakdown of the blood-brain barrier (BBB), the recruitment of lymphocytes, microglia, and macrophages to lesion sites, the presence of multiple ...
Genaro G. Ortiz, Fermín P. Pacheco-Moisés, Oscar K. Bitzer-Quintero, Ana C. Ramírez-Anguiano, Luis J. Flores-Alvarado, Viridiana Ramírez-Ramírez, Miguel A. Macias-Islas, Erandis D. Torres-Sánchez   +7 more
doaj   +1 more source

Enfermedades Mitocondriales: abordaje enfermero [PDF]

, 2016
Las enfermedades mitocondriales son un grupo de patologías progresivas y multisistémicas que se producen por deficiencia en la síntesis de energía en forma de ATP (adenosina trifosfato) en el proceso de fosforilación oxidativa.
Galende Calvo, Miriam
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Pérdida secundaria de la fotosíntesis: el caso de las algas incoloras y de algunos parásitos

Botan‪ical Sciences, 2017
Esta  revisión  pretende ilustrar un  fenómeno muy  interesante e n la  naturaleza: la perdida secundaria de  la fotosíntesis y sus efectos en los genomas del cloroplasto y de la mitocondria. Se describe cómo los genomas de los plástidos incoloros se han
Emma Berta Gutiérrez-Cirios-Madrid
doaj   +1 more source

Mitocondriopatías: las manifestaciones de una organela enferma. ¿Quién hace el diagnóstico? [PDF]

, 2006
Las enfermedades mitocondriales son relativamente comunes y resultan de defectos en la cadena respiratoria de esa organela. Sus manifestaciones pueden ser multisistémicas o localizadas en un solo tejido. Además, pueden ser adquiridas en forma esporádica
Altamirano, Eugenia
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