Antioxidant and anti-inflammatory effects in RAW264.7 macrophages of malvidin, a major red wine polyphenol. [PDF]
PLoS ONE, 2013 Background Red wine polyphenols can prevent cardiovascular and inflammatory diseases. Resveratrol, the most extensively studied constituent, is unlikely to solely account for these beneficial effects because of its rather low abundance and ...
Bognár, Eszter +7 more
core +16 more sources
Total ginsenosides suppress monocrotaline-induced pulmonary hypertension in rats: involvement of nitric oxide and mitogen-activated protein kinase pathways [PDF]
Journal of Ginseng Research, 2016 BackgroundGinsenosides have been shown to exert beneficial pharmacological effects on the central nervous, cardiovascular, and endocrine systems. We sought to determine whether total ginsenosides (TG) inhibit monocrotaline (MCT)-induced pulmonary ...
Du, Tianxin +7 more
core +4 more sources
Expanding the mitogen-activated protein kinase (MAPK) universe : an update on MAP4Ks [PDF]
Frontiers in Plant Science, 2020 Phosphorylation-mediated signaling cascades control plant growth and development or the response to stress conditions. One of the best studied signaling cascades is the one regulated by MITOGEN-ACTIVATED PROTEIN KINASEs (MAPKs).
De Smet, Ive, Pan, Lixia
core +3 more sources
Redox-dependent dimerization of p38 alpha mitogen-activated protein kinase with mitogen-activated protein kinase kinase 3 [PDF]
Journal of Biological Chemistry, 2017 The kinase p38α MAPK (p38α) plays a pivotal role in many biological processes. p38α is activated by canonical upstream kinases that phosphorylate the activation region. The purpose of our study was to determine whether such activation may depend on redox-
Bassi, R +7 more
core +9 more sources
Is Mitogen‐Activated Protein Kinase Phosphatase 5 a Solution to the Puzzle of the Mitogen‐Activated Protein Kinase Signal in Steatohepatitis? [PDF]
Hepatology Communications, 2019 While intensive investigations on MAPK signaling pathways discovered their critical functions in the development of obesity as well as steatohepatitis, the studies have also suggested their complexity. MKP5, a negative regulator of MAPK signaling, contributes to the improvement of steatohepatitis.
Kouichi Miura, Hironori Yamamoto
openaire +4 more sources
Mitogen-activated protein kinase signaling in plant pathogenic fungi [PDF]
PLoS Pathogens, 2018 Like in other eukaryotic organisms, mitogen-activated protein (MAP) kinase cascades play important roles in response to host and environmental signals in fungal pathogens.
Cong Jiang +3 more
semanticscholar +2 more sources
Mitogen-Activated Protein Kinase Cascades in Plant Hormone Signaling
Frontiers in Plant Science, 2018 Mitogen-activated protein kinase (MAPK) modules play key roles in the transduction of environmental and developmental signals through phosphorylation of downstream signaling targets, including other kinases, enzymes, cytoskeletal proteins or ...
P. Jagodzik +4 more
semanticscholar +3 more sources
The mitogen-activated protein kinase signal transduction pathway
Journal of Biological Chemistry, 1993 Roger J. Davis
openalex +2 more sources
Rice mitogen activated protein kinase kinase and mitogen activated protein kinase interaction network revealed by in-silico docking and yeast two-hybrid approaches. [PDF]
PLoS ONE, 2013 Protein-protein interaction is one of the crucial ways to decipher the functions of proteins and to understand their role in complex pathways at cellular level.
Dhammaprakash Pandhari Wankhede +3 more
doaj +1 more source
Inferring Compensatory Kinase Networks in Yeast using Prolog [PDF]
EPTCS 385, 2023, pp. 260-273, 2023 Signalling pathways are conserved across different species, therefore making yeast a model organism to study these via disruption of kinase activity. Yeast has 159 genes that encode protein kinases and phosphatases, and 136 of these have counterparts in humans.
arxiv +1 more source