Results 1 to 10 of about 458,508 (146)

The mitogen-activated protein kinase signal transduction pathway

Journal of Biological Chemistry, 1993
Roger J. Davis
openalex   +2 more sources

Mitogen-activated protein kinase cascades in plant signaling.

Journal of Integrative Plant Biology, 2022
Mitogen-activated protein kinase (MAPK) cascades are key signaling modules downstream of receptors/sensors that perceive either endogenously produced stimuli such as peptide ligands and damage-associated molecular patterns (DAMPs) or exogenously ...
Mengmeng Zhang, Shuqun Zhang
semanticscholar   +1 more source

Antioxidant and anti-inflammatory effects in RAW264.7 macrophages of malvidin, a major red wine polyphenol. [PDF]

, 2013
Background Red wine polyphenols can prevent cardiovascular and inflammatory diseases. Resveratrol, the most extensively studied constituent, is unlikely to solely account for these beneficial effects because of its rather low abundance and ...
Bognár, Eszter, Debreceni, Balázs, Gallyas, Ferenc, Kálmán, Nikoletta, Szabó, Alíz, Sárszegi, Zsolt, Sümegi, Balázs, Tucsek, Zsuzsanna   +7 more
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Identification of a Novel Inhibitor of Mitogen-activated Protein Kinase Kinase*

Journal of Biological Chemistry, 1998
The compound U0126 (1,4-diamino-2,3-dicyano-1,4-bis[2-aminophenylthio]butadiene) was identified as an inhibitor of AP-1 transactivation in a cell-based reporter assay. U0126 was also shown to inhibit endogenous promoters containing AP-1 response elements
M. Favata, K. Horiuchi, E. Manos, A. J. Daulerio, Deborah A. Stradley, W. Feeser, Drew E. Van Dyk, W. Pitts, R. Earl, F. Hobbs, R. Copeland, R. Magolda, P. Scherle, J. Trzăskos   +13 more
semanticscholar   +1 more source

Total ginsenosides suppress monocrotaline-induced pulmonary hypertension in rats: involvement of nitric oxide and mitogen-activated protein kinase pathways [PDF]

, 2015
BackgroundGinsenosides have been shown to exert beneficial pharmacological effects on the central nervous, cardiovascular, and endocrine systems. We sought to determine whether total ginsenosides (TG) inhibit monocrotaline (MCT)-induced pulmonary ...
Du, Tianxin, Feng, Dongxu, Qi, Muyao, Qin, Na, Sun, Hongzhi, Wang, Xinwen, Wu, Shufang, Yang, Wei   +7 more
core   +3 more sources

PD 098059 Is a Specific Inhibitor of the Activation of Mitogen-activated Protein Kinase Kinase in Vitro and in Vivo(*)

Journal of Biological Chemistry, 1995
PD 098059 has been shown previously to inhibit the dephosphorylated form of mitogen-activated protein kinase kinase-1 (MAPKK1) and a mutant MAPKK1(S217E,S221E), which has low levels of constitutive activity (Dudley, D. T., Pang, L., Decker, S.
D. Alessi, A. Cuenda, Philip R. Cohen, D. T. Dudley, A. Saltiel   +4 more
semanticscholar   +1 more source

Age-dependent motor dysfunction due to neuron-specific disruption of stress-activated protein kinase MKK7. [PDF]

, 2017
c-Jun N-terminal kinase (JNK) is a member of the mitogen-activated protein kinase family and controls various physiological processes including apoptosis. A specific upstream activator of JNKs is the mitogen-activated protein kinase kinase 7 (MKK7).
Deki-Arima, Norie, Fujimori-Tonou, Noriko, Hirayama, Jun, Iwatsuki, Mamiko, Kaneko, Asahito, Kawasaki, Hiroshi, Marth, Jamey D, Matsuoka, Masato, Miyamura, Norio, Nishina, Hiroshi, Okamoto-Uchida, Yoshimi, Penninger, Josef M, Shibata, Shigenobu, Yamanaka, Koji, Yamanashi, Yuji, Yamasaki, Tokiwa   +15 more
core   +2 more sources

Fucoidan Inhibits Smooth Muscle Cell Proliferation and Reduces Mitogen-activated Protein Kinase Activity [PDF]

, 2000
Objectives and design: fucoidan has previously been shown to inhibit the proliferation of arterial smooth muscle cells both in animal models and in vitro.
Gaciong, Z, Hedin, U, Kazi, M, Religa, P, Swedenborg, J, Thyberg, J   +5 more
core   +1 more source

Myocardial depressant effects of interleukin 6 in meningococcal sepsis are regulated by p38 mitogen-activated protein kinase [PDF]

, 2011
Our findings demonstrate an integral role of the p38 mitogen-activated protein kinase pathway in interleukin 6-mediated cardiac contractile dysfunction and inotrope insensitivity.
Abraham, Alizadeh, Angus, Asaduzzaman, Bellahcene, Benjamini, Bernard, Boucek, Branger, Chang, Checchia, Chen, Chen, Cheryl A. Hemingway, Chopra, Crackower, Cuenda, Cvijanovich, David A. Relman, Dhingra, Dong, Fourrier, Gentleman, Haralambous, Hariklia Eleftherohorinou, Hilger, Hotchkiss, Hubble, Jayne L. Dennis, Joanne L. Franklin, Kaminska, Kanehisa, Kishimoto, Kumar, Leblais, Levin, Liu, Liu, Ma, Martin, Mi, Michael Griffiths, Michael Levin, Mockridge, Narazaki, Nazima Pathan, Opal, Osuchowski, Padkin, Parasrampuria, Pathan, Pathan, Popper, Riedemann, Schumann, Shanley, Sian E. Harding, Simon J. Waddell, Smyth, Song, Su, Talmor, Victoria J. Wright, Waage, Wang, Watson, Yang, Yu, Zarubin   +68 more
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A synthetic inhibitor of the mitogen-activated protein kinase cascade.

Proceedings of the National Academy of Sciences of the United States of America, 1995
Treatment of cells with a variety of growth factors triggers a phosphorylation cascade that leads to activation of mitogen-activated protein kinases (MAPKs, also called extracellular signal-regulated kinases, or ERKs).
D. T. Dudley, L. Pang, S. Decker, A. Bridges, A. Saltiel   +4 more
semanticscholar   +1 more source