Results 141 to 150 of about 520,457 (360)

MicroRNA-197 reverses the drug resistance of fluorouracil-induced SGC7901 cells by targeting mitogen-activated protein kinase 1

, 2015
Hailin Xiong, Siwei Zhou, Aihua Sun, Ying He, Jun Li, Yuan Xia   +5 more
openalex   +2 more sources

Post‐transcriptional regulation of gene expression by mitogen‐activated protein kinase p38 [PDF]

, 2003
Andrew R. Clark, Jonathan L. E. Dean, Jeremy Saklatvala   +2 more
openalex   +1 more source

Polydatin alleviates mitochondrial damage and apoptosis of lung epithelial cells by inhibiting toll‐like receptor 4‐dependent macrophage activation in asthma

Animal Models and Experimental Medicine, EarlyView.
The alleviation of asthma by polydatin is dependent on the blockage of the toll‐like receptor 4 (TLR4)/P2X7R synergy in macrophages. The blockage of the TLR4/P2X7R synergy results in decreased release and secretion of interleukin‐1β (IL‐1β) and IL‐18. In epithelial cells, low IL‐1β and IL‐18 levels inhibit mitochondrial damage and apoptosis.
Guangxing Li, Ruobai Liu, Chang Xu, Jianing Yang, Yilan Song, Li Li, Jingzhi Jiang, Liangchang Li, Chongyang Wang, Guanghai Yan   +9 more
wiley   +1 more source

Mitogen-Activated Protein Kinase Pathway and Four Genes Involved in the Development of Benign Prostatic Hyperplasia: <i>In Vivo</i> and <i>Vitro</i> Validation

, 2022
Jiamin Gu, Xing‐Pei Guo, Lan Wu, Luyao Li, Cong Zhu, Tong Deng, Shuangying Wang, Cheng Fang, Xian‐Tao Zeng   +8 more
openalex   +1 more source

Mechanism of the Mitogen-Activated Protein Kinases/Mammalian Target of Rapamycin Pathway in the Process of Cartilage Endplate Stem Cell Degeneration Induced by Tension Load [PDF]

, 2022
Yu Zhang, Chen Liu, Yu Li, Hongguang Xu
openalex   +1 more source

Mitogen-Activated Protein Kinase Kinase [PDF]

, 2020
openaire   +1 more source

Functional analysis of oxidative stress-activated mitogen-activated protein kinase cascade in plants.

Proceedings of the National Academy of Sciences of the United States of America, 2000
Y. Kovtun, W. Chiu, Guillaume Tena, J. Sheen   +3 more
semanticscholar   +1 more source

Chronic high‐fat diet induces multi‐organ dysfunction and metabolic homeostasis disruption in Macaca fascicularis

Animal Models and Experimental Medicine, EarlyView.
An 18‐month HFD successfully established a translational Macaca fascicularis model replicating key metabolic disorders (MASH, diabetes, cardiac hypertrophy). MASH was determined by liver biopsy histology, the presence steatosis, inflammatory infiltration, hepatocytic ballooning, and fibrosis were considered as MASH; diabetes was diagnosed according to ...
Hongyi Chen, Wei Liu, Dan Zhou, Shuhua Liu, Yalun Guan, Zongyu Miao, Lei Cai, Xuejiao Li, Yunfeng Li, Zhongqiang Huang, Yi Jin, Ge Li, Yu Zhang   +12 more
wiley   +1 more source

Trametinib in Adults with Neurofibromatosis Type 1‐Related Symptomatic Plexiform Neurofibromas

Annals of Neurology, EarlyView.
Objective Mitogen‐activated protein kinase kinase inhibitors have shown promising results in treatment of plexiform neurofibromas in neurofibromatosis type 1 patients, but data in adults are limited. The aim of this phase 2 study was to investigate the efficacy and safety of trametinib in adults with neurofibromatosis type 1.
D. Christine Noordhoek, David F. Hanff, Pim J. French, Sarah A. van Dijk, Erik A.C. Wiemer, Olivier C. Manintveld, Martin J. van den Bent, Walter Taal   +7 more
wiley   +1 more source

p38 Mitogen-Activated Protein Kinase-Dependent Chemokine Production, Leukocyte Recruitment, and Hepatocellular Apoptosis in Endotoxemic Liver Injury

, 2005
Daniel Klintman, Xiang Li, Stefan Santén, René Schramm, Bengt Jeppsson, Henrik Thorlacius   +5 more
openalex   +1 more source