Results 161 to 170 of about 4,675,421 (262)

Mitochondria‐endoplasmic reticulum organelle glue as maturation promoter for origination/dimensional dual‐cross cardiomyocytes

BMEMat, EarlyView.
Mitochondria‐endoplasmic reticulum contact sites (MERCS) are areas where the mitochondria and endoplasmic reticulum closely interact. In this study, we utilize synthetic organelle glues to artificially engineer MERCS for regulating cardiomyocyte development, through which the immature and chemo‐plasticity issues of undifferentiated cells are addressed.
Wei Tang, Hao Sun, Chenqi Duan, Jiajia Chang, Yuxing Wang, Ming Zhao, Huiyue Zhao, Shan Lu, Yang Yang, Da Huo   +9 more
wiley   +1 more source

Dual Inhibitors of p38α Mitogen-Activated Protein Kinase and Butyrylcholinesterase for the Modulation of Neuroinflammation and Cognitive Dysfunction. [PDF]

J Med Chem
Knez D, Malinak D, Meden A, Ferjančič Benetik S, Pišlar A, Kohoutova Z, Vondrackova I, Psotka M, Lycka A, Pulkrabkova L, Soukup O, Skarka A, Andrys R, Brazzolotto X, Igert A, Dias J, Nachon F, Detka J, Targosiński F, Hliabovich D, Brunzelle JS, Shuvalova L, Sałat K, Roy SM, Watterson DM, Musílek K, Gobec S.   +26 more
europepmc   +1 more source

An all‐in‐one fucosylated gold nanocluster probe enables NIR‐II imaging and multi‐mechanistic therapy of acute kidney injury

BMEMat, EarlyView.
This study developed a fucoside‐targeted gold nanocluster probe that enables early NIR‐II imaging and multi‐mechanistic therapy for acute kidney injury, effectively mitigating oxidative stress, modulating inflammatory responses, and inhibiting ferroptosis to improve renal outcomes. Abstract Acute kidney injury (AKI) remains a life‐threatening condition
Ping Zhang, Boning Tan, Suqing Feng, Beibei Gu, Ting Feng, Haiguang Zhu, Jianping Xie, Xun Yuan   +7 more
wiley   +1 more source

Nanoagonist‐mediated spatiotemporal reprogramming of macrophage phenotypes to potentiate tumor immunotherapy

BMEMat, EarlyView.
This review systematically summarizes the major molecular mechanisms governing TAM polarization and their coordinated interactions. It further highlights recent advances in nanoagonist‐based strategies that intervene in these pathways to reprogram TAMs, critically discussing their therapeutic potential, current limitations, and translational prospects.
Siqi Fang, Fengfeng Xiao, Ruie Chen, Cuixia Lu, Yi Ju, Mingqing Yuan, Yunlu Dai, Liewei Wen   +7 more
wiley   +1 more source

Mycophenolate mofetil induces angiogenesis disorders in zebrafish embryos by inhibiting the mitogen-activated protein kinase signaling pathway. [PDF]

Biol Res
Wan M, Xiao Z, Shi X, Ye Z, Liu J, Liu X, Li H, Liao X, Zhang S, Xiao J, Cao Z.   +10 more
europepmc   +1 more source

Hot and cold deserts as eco‐evolutionary arenas for understanding plant resistance to multiple abiotic stressors

Biological Reviews, EarlyView.
ABSTRACT During their long evolutionary history, land plants have evolved a range of adaptations to different abiotic stressors. These help explain present‐day diversity and distribution patterns, as well as the potential resilience of natural and agricultural systems to a changing climate. Most previous research has focused on adaptation to individual
Marc Fradera‐Soler, Natasha Barbolini, Anže Žerdoner Čalasan, Marian Schubert, Catarina Rydin, Olwen M. Grace, Aelys M. Humphreys   +6 more
wiley   +1 more source

[Expression of Concern] JWA regulates human esophageal squamous cell carcinoma and human esophageal cells through different mitogen-activated protein kinase signaling pathways. [PDF]

Exp Ther Med
Lin J, Ma T, Jiang X, Ge Z, Ding W, Wu Y, Jiang G, Feng J, Cui G, Tan Y.   +9 more
europepmc   +1 more source

Expression pattern of the 10 mitogen-activated protein kinase kinases (MAPKK) encoded on <i>Arabidopsis thaliana</i> genome. [PDF]

Plant Signal Behav
Barrera-Ortiz S, González-Coronel JM, Casales-Tlatilpa Y, López-Bucio JS, Camargo-Pacanchique JD, Guevara-García ÁA.   +5 more
europepmc   +1 more source

Clinical Significance of Acute Kidney Injury in Idiosyncratic Drug‐Induced Liver Injury: A Multicentric Propensity Scores Matched Study

Clinical Pharmacology &Therapeutics, EarlyView.
Clinical significance of acute kidney injury in idiosyncratic drug‐induced liver injury: a multicentric propensity scores matched study. Evidence about the role of acute kidney injury (AKI) in idiosyncratic drug‐induced liver injury (DILI) is still scarce.
José María Pinazo‐Bandera, Hao Niu, Juan Pedro Toro‐Ortiz, Inmaculada Medina‐Caliz, Judith Sanabria‐Cabrera, Aída Ortega‐Alonso, Mercedes Robles‐Díaz, Daniel Enrique Di Zeo‐Sanchez, Nelia Hernández, Fernando Bessone, Vinicius Nunes, Raymundo Paraná, M. Isabel Lucena, Raul J. Andrade, Ismael Alvarez‐Alvarez, Miren García‐Cortés   +15 more
wiley   +1 more source

[Retracted] Homeobox B9 facilitates hypertrophic scar formation via activating the mitogen‑activated protein kinase signaling pathway. [PDF]

Mol Med Rep
Xie Q, Liu D, Yu M, Wu X, Zhao Y, Hu Q, Wang Q.   +6 more
europepmc   +1 more source