Results 321 to 330 of about 673,597 (383)

Mitogen‐activated protein kinases and asthma

Journal of Cellular Physiology, 2004
AbstractMitogen‐activated protein kinases (MAPKs) are evolutionary conserved enzymes which play a key role in signal transduction mediated by cytokines, growth factors, neurotransmitters and various types of environmental stresses. In the airways, these extracellular stimuli elicit complex inflammatory and structural changes leading to the typical ...
PELAIA G., CUDA G., VATRELLA S., GALLELLI L., CARAGLIA, Michele, MARRA M., ABBRUZZESE SACCARDI A., CAPUTI M., MASELLI R., COSTANZO F., MARSICO S. A.   +10 more
openaire   +4 more sources

Mitogen-activated protein kinase: conservation of a three-kinase module from yeast to human.

Physiological Reviews, 1999
Mitogen-activated protein kinases (MAPK) are serine-threonine protein kinases that are activated by diverse stimuli ranging from cytokines, growth factors, neurotransmitters, hormones, cellular stress, and cell adherence.
C. Widmann, S. Gibson, M. Jarpe, G. Johnson   +3 more
semanticscholar   +1 more source

Mitogen-activated protein kinases in schizophrenia

Biological Psychiatry, 1999
Mitogen-activated protein kinases (MAPKs) are important mediators of signal transduction from the cell surface to the nucleus and have been implicated in the integration of a variety of physiologic processes in most cells, including neurons. To investigate the possible involvement of MAPKs in schizophrenia, we compared the levels of the MAPK ...
Svetlana V. Kyosseva, W. Sue T. Griffin, Alan D. Elbein, Craig N. Karson, Melvin Lyon, Robert E. Mrak   +5 more
openaire   +3 more sources

The mitogen-activated protein kinase activator

Current Opinion in Cell Biology, 1992
The mitogen-activated protein kinase appears to be regulated by another growth factor regulated kinase, the mitogen-activated protein kinase activator. In the past year, much progress has been made in purifying and characterizing the mitogen-activated protein kinase activator, in determining its primary structure, and in identifying another protein ...
Rony Seger, Natalie G. Ahn, Edwin G. Krebs   +2 more
openaire   +3 more sources

Mitogen-activated protein kinase phosphatase: a negative regulator of the mitogen-activated protein kinase cascade

European Journal of Pharmacology, 1999
Mitogen-activated protein kinases (MAPKs) are activated by various stimuli, such as growth factors, cytokines, or stress, and are considered to be important mediators in intracellular signal transduction networks. The dual-specificity kinases, MAPK kinases (MKKs), which phosphorylate the TXY motif in the catalytic domain of MAPKs, can cause the ...
Masakazu Haneda, Ryuichi Kikkawa, Toshiro Sugimoto   +2 more
openaire   +3 more sources

Mitogen-Activated Protein Kinases in Endothelial Pathophysiology

Journal Of Investigative Medicine, 2003
Endothelial cells continuously respond to extracellular stimuli such as chemical signals produced by circulating blood elements or mechanical forces such as shear stress. Proinflammatory cytokines, mitogens, reactive oxygen species, and shear stress trigger signal molecules to initiate multiple intracellular pathways, which often converge at mitogen ...
Alexander D. Verin, Steven M. Dudek, Joe G.N. Garcia, Natalia V. Bogatcheva   +3 more
openaire   +3 more sources

Increased expression and subcellular translocation of the mitogen activated protein kinase kinase and mitogen-activated protein kinase in Alzheimer's disease

Neuroscience, 1995
The sequential activation of the mitogen-activated protein kinase kinase and its substrate, the mitogen-activated protein kinase is involved in a cascade of protein kinases which link a number of cell surface signals to intracellular changes in enzyme activity and gene expression.
A. Großmann, D. Zedlick, Th. Arendt, Max Holzer, M.K. Bru¨ckner   +4 more
openaire   +3 more sources

Mitogen-Activated Protein Kinase Assays

2007
Polymorphonuclear neutrophils (PMN) play an essential role in host defense against bacteria and fungi through coordinated responses such as adhesion, migration, phagocytosis, secretion, and activation of the NADPH oxidase. The mitogen-activated protein kinases (MAPKs) and their activation kinase cascades, which transduce signals from the plasma ...
Martine Torres, Martine Torres
openaire   +3 more sources

Novel mitogen-activated protein kinase kinase inhibitors

Expert Opinion on Investigational Drugs, 2011
the development of new drugs over the last few decades has targeted specific proteins thought to be a key to the disease state. MAPK kinases 1 and 2 (commonly known as MEK1-2) represent such proteins as they lie downstream of important drug targets for oncology, such as EGFR, RAS and RAF.
Jeffrey N. Miner, Mark S. Chapman
openaire   +3 more sources

Activation of Mitogen‐Activated Protein Kinases in Oligodendrocytes

Journal of Neurochemistry, 1996
Abstract: The proliferation and differentiation of oligodendrocyte progenitors are stringently controlled by an interacting network of growth and differentiation factors. Not much is known, however, about the intracellular signaling pathways activated in oligodendrocytes. In this study, we have examined the activation of mitogen‐activated protein (MAP)
Narayan R. Bhat, Peisheng Zhang
openaire   +3 more sources