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Mitogen-Activated Protein Kinases and Wound Stress [PDF]
, 2000 One of the most severe environmental stresses that plants encounter during their life cycle is wounding. Plants respond to wound stress by activating a set of genes that encode proteins involved in healing injured tissues. In recent years, mitogen-activated protein kinases have been implicated to be key signal molecules in the initial signal ...
Yuko Ohashi, Shigemi Seo
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Complexes of Ras.GTP with Raf-1 and mitogen-activated protein kinase kinase.
Science, 1993The guanosine triphosphate (GTP)-binding protein Ras functions in regulating growth and differentiation; however, little is known about the protein interactions that bring about its biological activity.
S. Moodie +3 more
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Mitogen-Activated Protein Kinases and Cerebral Ischemia
Molecular Neurobiology, 2001Mitogen-activated protein kinases (MAPKs) have crucial roles in signal transduction from the cell surface to the nucleus and regulate cell death and survival. Recent papers support the hypothesis that neuronal apoptosis and cerebral ischemia induce the robust activation of MAPK cascades.
Nobuo Hashimoto +2 more
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Mitogen-Activated Protein Kinase Signaling
2004The mechanism by which cells respond to extracellular stimuli involves a series of signal transduction events across the cell membrane and through the cytoplasm to the nucleus. Mitogen-activated protein (MAP) kinases are important mediators of signal transduction and play a key role in the regulation of many cellular processes, such as cell growth and ...
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p38 mitogen-activated protein kinase and pain
Life Sciences, 2020Inflammatory and neuropathic pain is initiated by tissue inflammation and nerve injury, respectively. Both are characterized by increased activity in the peripheral and central nervous system, where multiple inflammatory cytokines and other active molecules activate different signaling pathways that involve in the development and/or maintenance of pain.
Lijia Mai +4 more
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Microtubules and mitogen-activated protein kinase signalling
Current Opinion in Plant Biology, 2011Subcellular signalling by mitogen-activated protein kinases (MAPKs) was originally regarded as a means to regulate microtubule (MT) organization and dynamics, but with time MAPKs were assigned to broader roles concerning biotic and abiotic signal transductions.
Peter Illes +3 more
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Mitogen-Activated Protein Kinase Kinase 4 (MKK4)
The International Journal of Biochemistry & Cell Biology, 2000The Mitogen-Activated Protein Kinase Kinase 4 (MKK4), a member of the MAP kinase kinase family, directly phosphorylates and activates the c-Jun NH2-terminal kinases (JNK), in response to cellular stresses and proinflammatory cytokines. JNK is a member of the MAP kinase family and a key component of a stress activated protein kinase signalling pathway ...
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Targeting Mitogen-Activated Protein Kinases for Asthma
Current Drug Targets, 2006Allergic asthma is a chronic airway inflammatory disorder attributable to T-helper 2 cell responses together with other inflammatory cells such as mast cells, B cells and eosinophils, and pro-inflammatory cytokines and chemokines. Mitogen-activated protein kinase (MAPK) signaling cascades have been shown to be important in the differentiation ...
W.S. Wong, Wei Duan
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Mitogen-activated protein kinase in human eggs
Zygote, 1999Mitogen-activated protein (MAP) kinase in human eggs has been investigated by using immunoblotting with both anti-Active MAPK and anti-ERK2 antibodies. The results showed that the main form of MAP kinase was p42ERK2. It was in a dephosphorylated form in oocytes at the germinal vesicle stage, but fully phosphorylated in unfertilised mature eggs.
Yael Gonen +5 more
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Mitogen-activated protein kinase pathway in osteosarcoma
Pathology, 2012The MAPK pathway has been shown to contribute to the prognostic role and drug resistance in many cancers. In addition, the MAPK pathway was found to play a role in the aggressive behaviour of osteosarcoma (OS). We hypothesised that the expression of the MAPK pathway components may be of value in predicting the prognosis of patients with OS.We evaluated
Kiyong Na, Youn Wha Kim, Yong-Koo Park
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