Results 231 to 240 of about 369,896 (355)

Platelet-derived-growth-factor stimulation of the p42/p44 mitogen-activated protein kinase pathway in airway smooth muscle: role of pertussis-toxin-sensitive G-proteins, c-Src tyrosine kinases and phosphoinositide 3-kinase

, 1999
Ann-Marie Conway, Soma Rakhit, Susan Pyne, Nigel J. Pyne   +3 more
openalex   +1 more source

Oral Squamous Cell Carcinoma‐Risk Factors, Diagnosis, Treatment, and Prevention

Cancer Nexus, EarlyView.
ABSTRACT Oral squamous cell carcinoma (OSCC) usually originates from the precancerous lesions of oral mucosa and accounts for approximately 90% of oral cancers. In‐depth understanding of pathogenesis, hallmarks, and etiological factors is a crucial prerequisite for advancing the diagnosis and treatment for OSCC patients. This review aims to present the
Liping Wang, Xiaole Liu, Mengjie Chen, Ying Hu, Lilei Zhu   +4 more
wiley   +1 more source

Phosphoproteome-Entailed Kinase-Substrate Landscape of Human-DENV-2 Interaction. [PDF]

Int J Mol Sci
Jabbar AA, Shaji V, Anil A, Nisar M, Soman S, Prasad G, Abhinand CS, Modi PK, Madanan MG, Jayanandan A, Pilankatta R, Raju R.   +11 more
europepmc   +1 more source

Orthovanadate Stimulates cAMP Phosphodiesterase 3 Activity in Isolated Rat Hepatocytes through Mitogen-Activated Protein Kinase Activation Dependent on cAMP-Dependent Protein Kinase

, 2004
Tomoyasu WATANABE, Hirofumi Satoo, Kazuhisa Kohara, Reiko Takami, Toshio Motoyashiki, Tetsuo Morita, Hiroshi Ueki   +6 more
openalex   +2 more sources

Fibroblast Plasticity in Inflammation of the Barrier

Barrier Immunity, EarlyView.
Under inflammatory condition, fibroblasts in barrier tissues integrate inflammatory, senescent, and mechanical inputs. These pathways activate central signaling networks to drive fibroblast phenotypic transition, enabling cytokine production, immune cell recruitment, and extracellular matrix remodeling.
Chen Zhang, Hao Wu, Wei Li
wiley   +1 more source

Roles of phosphatidylinositol 3‐kinase and p38 mitogen‐activated protein kinase in the regulation of protein kinase C‐α activation in interferon‐γ‐stimulated macrophages [PDF]

, 2009
Pierre‐Olivier Hardy, Tamsir O. Diallo, Christine Matte, Albert Descoteaux   +3 more
openalex   +1 more source

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

Regulation of Cell Proliferation and Migration by Extracellular Phosphatidic Acid. [PDF]

Biomedicines
Gomez-Larrauri A, Benito-Vicente A, Uribe KB, Martin C, Gomez-Muñoz A.   +4 more
europepmc   +1 more source

A new therapeutic strategy for spotted fever group rickettsioses: a proposal for evaluating combination therapy with tetracycline and fluoroquinolones. [PDF]

Front Cell Infect Microbiol
Itoh K, Tsutani H, Mitsuke Y, Ikawa M, Iwasaki H.   +4 more
europepmc   +1 more source

Insulin‐like growth factor 1 receptor correlates with verbal memory in ILAE type 2 hippocampal sclerosis

Epilepsia, EarlyView.
Abstract Objective Long‐term memory deficits are often seen in patients with temporal lobe epilepsy (TLE). Recently, studies showed that patients with hippocampal sclerosis (HS) type 2, which presents with severe neuron loss in CA1 only, performed within the normal range. However, up to 30% of HS type 2 cases have memory deficits.
Henrique Cruz, Amauri Batista de Oliveira‐Júnior, André Fernando Garcia Cortez, Ricardo Lutzky Saute, Ricardo Silva Centeno, Joao Norberto Stávale, Mirian Salvadori Bittar Guaranha, Elza Marcia Targas Yacubian, Esper Abrão Cavalheiro, Joao Pereira Leite, Jose Eduardo Peixoto‐Santos   +10 more
wiley   +1 more source