Results 311 to 320 of about 234,943 (363)

Dexmedetomidine Blocks the ERK Pathway by Inhibiting MAP3K8 to Achieve a Protective Effect in Lung Ischemia/Reperfusion Injury

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Lung ischemia/reperfusion injury (LIRI) is a primary contributor to morbidity and mortality following lung transplantation. Dexmedetomidine (DEX) protects the lungs from I/R injury, but the underlying mechanisms remain uncertain. This paper examined the protective effect of DEX in LIRI and elucidated the potential regulation involved. LIRI was
Chun‐Huan Hu, Ru Qian, Yong‐Bo Wang, Lian‐Di Li, Chun‐Xing Miao   +4 more
wiley   +1 more source

The Molecular Basis of Pediatric Brain Tumors: A Review with Clinical Implications. [PDF]

Cancers (Basel)
Antoniades E, Keffes N, Vorri S, Tsitouras V, Gkantsinikoudis N, Tsitsopoulos P, Magras J.   +6 more
europepmc   +1 more source

Effects of a high‐fat diet on gut microbiota and possible implications for bone health in male Wistar rats

Lipids, EarlyView.
Abstract Diet plays an important role in the composition of gut microbiota. Emerging research suggests that bone homeostasis can also be influenced by the gut microbiota. The aim of this study was to assess possible alterations in gut microbiota in an experimental obesity model induced by a high‐fat diet (HFD) and the possible effects on parameters of ...
Fernanda Guedes Rodrigues, Milene Subtil Ormanji, Renata Meca, Horácio Montenegro, Lilian Cuppari, Martin H. de Borst, Ita Pfeferman Heilberg   +6 more
wiley   +1 more source

Exploring recent advances in signaling pathways and hallmarks of uveal melanoma: a comprehensive review. [PDF]

Explor Target Antitumor Ther
Banimohammad M, Khalafi P, Gholamin D, Bangaleh Z, Akhtar N, Solomon AD, Prabhakar PK, Sanami S, Prakash A, Pazoki-Toroudi H.   +9 more
europepmc   +1 more source

Self‐Assembly of Noncanonical Peptides: A New Frontier in Cancer Therapeutics and Beyond

Macromolecular Bioscience, EarlyView.
Representative examples of noncanonical peptide assemblies in anticancer therapeutics, biomaterials, regenerative medicine, molecular imaging, and catalysis are discussed, highlighting enzyme‐instructed self‐assembly as a valuable approach for constructing biomimetic and bioinspired materials that bridge the interface between biological systems and ...
Lin Bai, Meihui Yi, Bing Xu
wiley   +1 more source

MAP Kinase Phosphatase-5 Deficiency Improves Endurance Exercise Capacity. [PDF]

Cells
Perales JA, Lawan A, Bajpeyi S, Han SM, Bennett AM, Min K.   +5 more
europepmc   +1 more source

The Hsp90β Isoform: An Attractive Target for Drug Development

Medicinal Research Reviews, EarlyView.
ABSTRACT The beta isoform of 90 kDa heat shock protein (Hsp90β) plays a critical role in maintaining cellular proteostasis by assisting in the folding and refolding of proteins, which is essential for both normal cellular function and stress response.
Subhabrata Chaudhury, Terin D'Amico, Brian S. J. Blagg   +2 more
wiley   +1 more source

Therapeutic Strategies for Drug-resistant Melanoma and Their Clinical Implications. [PDF]

J Cancer Prev
Huang K, Kim MO.
europepmc   +1 more source

Xanomeline‐Trospium Chloride (Cobenfy): A New Era in Managing Schizophrenia—Comparative Effectiveness and Economic Challenges

Medicine Advances, EarlyView.
Xanomeline‐trospium chloride (cobenfy) is a muscarinic agonist used to treat hallucinations and psychotic illnesses such as Alzheimer's and Schizophrenia. It has been constructed for patients who are unable to tolerate dopamine‐targeting therapies and a comparison is drawn against other similar drugs with variables like cost, mechanism of action ...
Jawairya Muhammad Hussain, Wajiha Arif, Sharjeel Humayun, Nida Shoaib, Saim Mahmood Khan   +4 more
wiley   +1 more source

Diabetic Kidney Disease: Disease Progression Driven by Positive Feedback Loops and Therapeutic Strategies Targeting Pathogenic Pathways. [PDF]

Diabetes Metab Syndr Obes
Mo GP, Zhu Y, You Y, Chen H, Zhang J, Ku B, Yu H, Peng Z.   +7 more
europepmc   +1 more source