Results 31 to 40 of about 234,943 (363)
Human mitogen-activated protein kinase kinase kinase mediates the stress-induced activation of mitogen-activated protein kinase cascades [PDF]
Biochemical Journal, 1998 The mitogen-activated protein kinase (MAPK) cascades represent one of the important signalling mechanisms in response to environmental stimuli. We report the identification of a human MAPK kinase kinase, MAPKKK4, via sequence similarity with other MAPKKKs. When truncated MAPKKK4 (ΔMAPKKK4) was overexpressed in HEK293 cells, it was constitutively active
Robert Weaver, Po-Ying Chan-Hui
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Phosphoregulators:protein kinases and protein phosphatases of mouse [PDF]
, 2003 With the completion of the human and mouse genome sequences, the task now turns to identifying their encoded transcripts and assigning gene function. In this study, we have undertaken a computational approach to identify and classify all of the protein ...
+7 more
core +2 more sources
Role of mitogen-activated protein kinase kinase kinases in signal integration [PDF]
Oncogene, 2007 Mitogen-activated protein kinases (MAPKs) are members of a dynamic protein kinase network through which diverse stimuli regulate the spatio-temporal activities of complex biological systems. MAPKs regulate critical cellular functions required for homeostasis such as the expression of cytokines and proteases, cell cycle progression, cell adherence ...
Bruce D. Cuevas +2 more
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PLoS ONE, 2014 A protoberberine derivative library was used to search for selective inhibitors against kinases of the mitogen-activated protein kinase (MAPK) cascades in mammalian cells.
Namil Kim +6 more
doaj +1 more source
Positional information readout in $Ca^{2+}$ signaling [PDF]
Phys. Rev. Lett. 123, 058102 (2019), 2017 Living cells respond to spatial signals. Signal transmission to the cell interior often involves the release of second messengers like $Ca^{2+}$ . They will eventually trigger a physiological response by activating kinases that in turn activate target proteins through phosphorylation. Here, we investigate theoretically how positional information can be
arxiv +1 more source
Signals fly when kinases meet Rho-of-plants (ROP) small G-proteins [PDF]
, 2015 Rho-type small GTP-binding plant proteins function as two-state molecular switches in cellular signalling. There is accumulating evidence that Rho-of-plants (ROP) signalling is positively controlled by plant receptor kinases, through the ROP guanine ...
Fehér, Attila, Lajkó Dézi, Bianka
core +1 more source
Mitogen-activated protein kinase cascades in Vitis vinifera
Frontiers in Plant Science, 2015 Protein phosphorylation is one of the most important mechanisms to control cellular functions in response to external and endogenous signals. Mitogen-activated protein kinases (MAPK) are universal signaling molecules in eukaryotes that mediate the ...
Birsen eÇAKIR, Ozan eKılıçkaya
doaj +1 more source
Advance in Reversible Covalent Kinase Inhibitors [PDF]
arXiv, 2021 Reversible covalent kinase inhibitors (RCKIs) are a class of novel kinase inhibitors attracting increasing attention because they simultaneously show the selectivity of covalent kinase inhibitors, yet avoid permanent protein-modification-induced adverse effects.
arxiv
The role of p38 MAPK and its substrates in neuronal plasticity and neurodegenerative disease [PDF]
, 2012 A significant amount of evidence suggests that the p38-mitogen-activated protein kinase (MAPK) signalling cascade plays a crucial role in synaptic plasticity and in neurodegenerative diseases.
Corrêa, Sônia A. L. +1 more
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Role of mitogen-activated protein kinase kinase 4 in cancer [PDF]
Oncogene, 2007 Mitogen-activated protein (MAP) kinase kinase 4 (MKK4) is a component of stress activated MAP kinase signaling modules. It directly phosphorylates and activates the c-Jun N-terminal kinase (JNK) and p38 families of MAP kinases in response to environmental stress, pro-inflammatory cytokines and developmental cues.
Whitmarsh, A. J., Davis, R. J.
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