Results 91 to 100 of about 40,054 (307)

Substrate‐dependent control of MAPK phosphorylation in vivo

Molecular Systems Biology, 2011
Phosphorylation of the mitogen‐activated protein kinase (MAPK) is essential for its enzymatic activity and ability to control multiple substrates inside a cell.
Yoosik Kim, Ze'ev Paroush, Knud Nairz, Ernst Hafen, Gerardo Jiménez, Stanislav Y Shvartsman   +5 more
doaj   +1 more source

Systematic Global Analysis of Genes Encoding Protein Phosphatases in Aspergillus fumigatus. [PDF]

, 2015
Aspergillus fumigatus is a fungal pathogen that causes several invasive and noninvasive diseases named aspergillosis. This disease is generally regarded as multifactorial, considering that several pathogenicity determinants are present during the ...
Alowni, R, Alves de Castro, P, Bom, VL, Brown, NA, Dolan, SK, Doyle, S, Fernanda Dos Reis, T, Goldman, GH, Hagiwara, D, Jones, GW, Winkelströter, LK   +10 more
core   +1 more source

Redox Control of Protein Tyrosine Phosphatases and Mitogen-Activated Protein Kinases in Plants [PDF]

Plant Physiology, 2003
Environmental conditions, including light, temperature, water status, and soil salinity, all modify the redox state of plant cells ([Allen et al., 1995][1]). A number of studies have shown that oxidative stress is a common factor that affects plant growth and development under extreme ...
Rajeev, Gupta, Sheng, Luan
openaire   +2 more sources

Optimizing Diagnostic Accuracy of Clinical Red Flags in RASopathies

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT RASopathies are a group of genetic disorders caused by pathogenic variants in the RAS‐mitogen‐activated protein kinase (RAS–MAPK) signaling pathway, often presenting with congenital heart defects, craniofacial dysmorphisms, and developmental delays. To assess the diagnostic yield of genetic testing in patients with suspected RASopathies and to
Emanuele Bobbio, Martina Caiazza, Emanuele Monda, Giustina Aruta, Alberto Budillon, Augusto Esposito, Adelaide Fusco, Annapaola Cirillo, Marta Rubino, Immacolata Viscovo, Gioacchino Scarano, Matteo Della Monica, Vincenzo Nigro, Giulio Piluso, Leandro Pecchia, Maria Giovanna Russo, Giuseppe Limongelli   +16 more
wiley   +1 more source

Manipulation of macrophage signaling by Leishmania virulence factors

Virulence
Leishmania, a macrophage-residing parasite, expresses virulence factors that intercept macrophage signaling and inflicts leishmaniasis. Recently described virulence factors- eEF-1α (eukaryotic elongation factor), LmjF_36_3850 (Leishmania major F_36_3850),
Dhiraj Gurjar, Neelam Bodhale, Divanshu Shukla, Debadatta Nayak, Nibedita Lenka, Bhaskar Saha   +5 more
doaj   +1 more source

Ischemia/reperfusion-induced MKP-3 impairs endothelial NO formation via inactivation of ERK1/2 pathway. [PDF]

PLoS ONE, 2012
Mitogen-activated protein kinase phosphatases (MKPs) are a family of dual-specificity phosphatases. Endothelial cells express multiple MKP family members, such as MKP-3.
Dan Yang, Ping Xie, Zhihua Liu
doaj   +1 more source

The 9th International RASopathies Symposium

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT The RASopathies are a group of congenital disorders with overlapping clinical manifestations that are caused by pathogenic germline or early somatic variants that result in the hyperactivation of the RAS/mitogen‐activated protein kinase (MAPK) signaling pathway.
Pau Castel, Lisa Schoyer, Beth Stronach, Raya Bogdanova, Anton M. Bennett, Jaishri Blakeley, Miriam Bornhorst, Tammy Bowers, Saskia M. Brachmann, Emma Burkitt‐Wright, Kathryn Chatfield, Alessandro De Luca, Khalil El‐Chammas, Abdul Elkadri, John E. Fortunato, Bruce D. Gelb, Anne Goriely, Karen Gripp, Kassidy Grover, Lindsay Homan, Kenneth A. Kern, Maija Kiuru, Charles (Chuck) Lawson, Yong‐Seok Lee, Frank McCormick, Gina Ney, Cristina Nuevo‐Tapioles, Sara Pardej, Elizabeth I. Pierpont, Julia Plank, Nancy Ratner, Katherine A. Rauen, J. Elliott Robinson, Les Rogers, Sarah E. Sheppard, Keir Shiels, David Stevenson, Dagmar Tiemens, Matthew Traylor, K. Nicole Weaver, Marielle Yohe, Tamar Green   +41 more
wiley   +1 more source

Enhanced conversion of T cells into CAR T cells by modulation of the MAPK/ERK pathway

Cell Reports Medicine
Summary: Delivery of chimeric antigen receptors (CARs) to T cells is usually mediated by lentiviral vectors (LVs), which can have broad tropism or be T cell targeted.
Elham Adabi, Filippos T. Charitidis, Frederic B. Thalheimer, Mar Guaza-Lasheras, Colin Clarke, Christian J. Buchholz   +5 more
doaj   +1 more source

PTPRO represses colorectal cancer tumorigenesis and progression by reprogramming fatty acid metabolism

Cancer Communications, 2022
Background Abnormal expression of protein tyrosine phosphatases (PTPs) has been reported to be a crucial cause of cancer. As a member of PTPs, protein tyrosine phosphatase receptor type O (PTPRO) has been revealed to play tumor suppressive roles in ...
Weixing Dai, Wenqiang Xiang, Lingyu Han, Zixu Yuan, Renjie Wang, Yanlei Ma, Yongzhi Yang, Sanjun Cai, Ye Xu, Shaobo Mo, Qingguo Li, Guoxiang Cai   +11 more
doaj   +1 more source

Characterization of ROP GTPase-activated Arabidopsis receptor-like cytoplasmic kinases (RLCK class VI_A) [PDF]

, 2011
Plants have to respond and adapt to a variety of continuously changing environmental factors in order to establish an appropriate developmental strategy to ensure survival. There are ample data showing that protein phosphorylation/dephosphorylation plays
Jurca Elena Manuela
core