Results 81 to 90 of about 40,054 (307)

The Trichinella Super‐Pangenome Reveals the Evolution of Encapsulation and Predicted Host–Parasite Protein Interactions

Advanced Science, EarlyView.
ABSTRACT The muscle capsule of Trichinella is a critical structure that impedes immune attacks and drug penetration, yet the molecular mechanisms underlying its formation remain poorly understood. Using a high‐quality super‐pangenome comprising 12 Trichinella species, we compared extensive genomic variations between encapsulating and non‐encapsulating ...
Qingbo Lv, Yi Liu, Ning Xu, Xiao Zhang, Yaming Yang, Chengyao Li, Hanhai Mao, Mingyuan Liu, Xiaolei Liu   +8 more
wiley   +1 more source

Dual-Specificity Phosphatase 12 Targets p38 MAP Kinase to Regulate Macrophage Response to Intracellular Bacterial Infection

Frontiers in Immunology, 2017
The mitogen-activated protein kinase (MAPK) cascades are activated in innate immune cells such as macrophages upon the detection of microbial infection, critically regulating the expression of proinflammatory cytokines and chemokines such as TNF-α, IL-6,
Sharol Su Lei Cho, Sharol Su Lei Cho, Jian Han, Jian Han, Sharmy J. James, Sharmy J. James, Chin Wen Png, Chin Wen Png, Madhushanee Weerasooriya, Madhushanee Weerasooriya, Sylvie Alonso, Sylvie Alonso, Yongliang Zhang, Yongliang Zhang   +13 more
doaj   +1 more source

Regulation of atypical MAP kinases ERK3 and ERK4 by the phosphatase DUSP2 [PDF]

, 2017
The atypical MAP kinases ERK3 and ERK4 are activated by phosphorylation of a serine residue lying within the activation loop signature sequence S-E-G. However, the regulation of ERK3 and ERK4 phosphorylation and activity is poorly understood.
A De la Mota-Peynado, A Kucharska, AE Stewart, DM Owens, DN Slack, E Aberg, E Aberg, FA Gonzalez, H Sun, J Sirois, JM Brondello, KL Jeffrey, M Camps, M Karlsson, M Mandl, M Marquis, M Marquis, M Perander, MJ Robinson, OM Seternes, OM Seternes, P Coulombe, P Deleris, P Deleris, PJ Rohan, Q Zhang, RJ Dickinson, RJ Dickinson, S Kant, S Schumacher, SE Kim, T Tanoue, TG Boulton, W Wei, Y Chu, Y Ward   +35 more
core   +4 more sources

Inhibition of mitogen-activated protein kinase by a Drosophila dual-specific phosphatase [PDF]

Biochemical Journal, 2000
The Drosophila extracellular signal-regulated kinase (DERK) mitogen-activated protein kinase (MAPK) is involved in the regulation of multiple differentiation and developmental processes. Tight control of MAPK activity is critical for normal cell behaviour.
W J, Lee, S H, Kim, Y S, Kim, S J, Han, K S, Park, J H, Ryu, M W, Hur, K Y, Choi   +7 more
openaire   +2 more sources

Multi‐Omics Insights Into the Mechanisms of Early Muscle Fiber Difference and Transformation Between Lean‐Type and Chinese Indigenous Pigs

Advanced Science, EarlyView.
Multi‐omics analyses uncover breed‐specific cis‐regulatory landscapes and higher‐order chromatin architectural differences that underlie early postnatal muscle fiber divergence in pigs. A super‐enhancer upstream of PPP3CB recruits MEF2C to activate PPP3CB transcription, while the PPP3CB–MEF2C positive feedback loop promotes oxidative muscle fiber ...
Shuailong Zheng, Hainan Wu, Min Liu, Kunpeng Wu, Shuntao Huang, Zulfiqar Ahmed, Lenox Pius, Mengjin Zhu, Dequan Xu   +8 more
wiley   +1 more source

Role of the protein tyrosine phosphatase Shp2 in homeostasis of the intestinal epithelium.

PLoS ONE, 2014
Protein tyrosine phosphorylation is thought to be important for regulation of the proliferation, differentiation, and rapid turnover of intestinal epithelial cells (IECs).
Hironori Yamashita, Takenori Kotani, Jung-Ha Park, Yoji Murata, Hideki Okazawa, Hiroshi Ohnishi, Yonson Ku, Takashi Matozaki   +7 more
doaj   +1 more source

Transcriptomic insights into the effects of CytCo, a novel nematotoxic protein, on the pine wood nematode Bursaphelenchus xylophilus

BMC Genomics, 2021
Background The pine wood nematode Bursaphelenchus xylophilus is a destructive pest of Pinus trees worldwide and lacks effective control measures. Screening for nematotoxic proteins has been undertaken to develop new strategies for nematode control ...
Ye Chen, Xiang Zhou, Kai Guo, Sha-Ni Chen, Xiu Su   +4 more
doaj   +1 more source

The MAP Kinase Phosphatase MKP-1 Modulates Neurogenesis via Effects on BNIP3 and Autophagy

Biomolecules, 2021
Inherited and acquired defects in neurogenesis contribute to neurodevelopmental disorders, dysfunctional neural plasticity, and may underlie pathology in a range of neurodegenerative conditions.
Yinghui Li, Marc W. Halterman
doaj   +1 more source

Purification and Kinetic Characterization of the Mitogen-activated Protein Kinase Phosphatase rVH6 [PDF]

Journal of Biological Chemistry, 1996
The dual specificity protein-tyrosine phosphatase rVH6 belongs to a subfamily of enzymes that have in vivo and in vitro catalytic activity against mitogen-activated protein kinases. A method was developed for the expression and efficient purification of recombinant rVH6 in quantities sufficient for physical and kinetic characterization of the enzyme ...
A M, Wiland, J M, Denu, R J, Mourey, J E, Dixon   +3 more
openaire   +2 more sources

Nuclear Mechanotransduction Across the Metastatic Cascade: Decoding Spatiotemporal Heterogeneity in Cancer Dissemination

Advanced Science, EarlyView.
Tumor metastasis results from complex interactions between cancer cells and mechanical microenvironments. We propose a “nucleus‐centered, cross‐stage mechanical signal decoding” model, highlighting how nuclear mechanosensors interpret forces at different stages.
Linqi Song, Jingyang Liu, Xue Wang, Minpu Zhang, Changgang Sun   +4 more
wiley   +1 more source