Results 101 to 110 of about 40,054 (307)

Dual-Specificity Phosphatases in Neuroblastoma Cell Growth and Differentiation [PDF]

, 2019
Dual-specificity phosphatases (DUSPs) are important regulators of neuronal cell growth and differentiation by targeting proteins essential to neuronal survival in signaling pathways, among which the MAP kinases (MAPKs) stand out.
Aurtenetxe, Olaia, López Almaraz, Ricardo, López Fernández de Villaverde, José Ignacio, Nunes Xavier, Caroline E., Pulido Murillo, Rafael, Zaldumbide Dueñas, Laura   +5 more
core   +2 more sources

Tree shrew model of early diabetic retinopathy reveals microvascular dysfunction and identifies phosphoserine aminotransferase 1 as a novel therapeutic target

Animal Models and Experimental Medicine, EarlyView.
We developed an animal model of early diabetic retinopathy (DR) in the tree shrew by feeding a high‐fat and high‐sugar diet in combination with STZ. Physiological and biochemical index detection, hematoxylin and eosin staining, and transmission electron microscopy were performed to examine DR.
Min Qiu, Shurui Huo, Wenguang Wang, Na Li, Qingwei Zeng, Xiaomei Sun, Jiejie Dai, Pinfen Tong, Yuanyuan Han, Ling Zhao, Caixia Lu   +10 more
wiley   +1 more source

Enzyme Is the Name—Adapter Is the Game

Cells
Signaling proteins in eukaryotes usually comprise a catalytic domain coupled to one or several interaction domains, such as SH2 and SH3 domains. An additional class of proteins critically involved in cellular communication are adapter or scaffold ...
Michael Huber, Tilman Brummer
doaj   +1 more source

Drosophila heat shock response requires the jnk pathway and phosphorylation of mixed lineage kinase at a conserved serine-proline motif [PDF]

, 2012
Defining context specific requirements for proteins and pathways is a major challenge in the study of signal transduction. For example, the stress-activated protein kinase (SAPK) pathways are comprised of families of closely related transducers that are ...
Garlena, RA, Gonda, RL, Stronach, B
core   +5 more sources

Mitogen-activated protein kinase phosphatase is required for genotoxic stress relief inArabidopsis [PDF]

Genes & Development, 2001
Genotoxic stress activates complex cellular responses allowing for the repair of DNA damage and proper cell recovery. Although plants are exposed constantly to increasing solar UV irradiation, the signaling cascades activated by genotoxic environments are largely unknown.
Ulm, Roman, Revenkova, E., di Sansebastiano, G. P., Bechtold, N., Paszkowski, Jerzy   +4 more
openaire   +5 more sources

Molecular mechanism of ischemic postconditioning in promoting diabetic ischemic brain injury repair via the microRNA‐34a–BDNF–SIX3 signaling axis

Animal Models and Experimental Medicine, EarlyView.
Diabetes combined with ischemic stroke (DMIS) exacerbates brain infarct size and neuronal damage compared to nondiabetic ischemic stroke (IS). This study reveals that microRNA‐34a (miR‐34a) plays a key role in DMIS pathogenesis: miR‐34a directly targets and suppresses brain‐derived neurotrophic factor (BDNF) and Sine oculis homeobox 3 (SIX3), promoting
Ling Zhao, Chunlan Zou, Junxian Li, Yang Yang, Yuanyuan Han, Tingyu Ke   +5 more
wiley   +1 more source

Syk inhibitors reduce tau protein phosphorylation and oligomerization

Neurobiology of Disease
Spleen tyrosine kinase (Syk), a non-receptor-type tyrosine kinase, has a wide range of physiological functions. A possible role of Syk in Alzheimer's disease (AD) has been proposed.
Tomohisa Yamaguchi, Tadanori Hamano, Kiyonao Sada, Rei Asano, Nicholas M. Kanaan, Hirohito Sasaki, Shu-Hui Yen, Yuki Kitazaki, Yoshinori Endo, Soichi Enomoto, Norimichi Shirafuji, Masamichi Ikawa, Osamu Yamamura, Youshi Fujita, Koji Aoki, Hironobu Naiki, Maho Morishima, Yuko Saito, Shigeo Murayama, Yasunari Nakamoto   +19 more
doaj   +1 more source

Phosphatidic acid, a versatile water-stress signal in roots

Frontiers in Plant Science, 2013
Adequate water supply is of utmost importance for growth and reproduction of plants. In order to cope with water deprivation, plants have to adapt their development and metabolism to ensure survival.
Fionn eMcLoughlin, Christa eTesterink
doaj   +1 more source

Mitogen-Activated Protein Kinase Phosphatase-1 Is Overexpressed in Non-Small Cell Lung Cancer and Is an Independent Predictor of Outcome in Patients [PDF]

, 2004
An increase in the activity of the mitogen-activated protein kinases (MAPKs) has been correlated with a more malignant phenotype in several tumor models in vitro and in vivo. A key regulatory mechanism of the MAPKs [extracellular signal-regulated kinase (
Garayoa, M. (Mercedes), Lopez-Picazo, J.M. (José M.), Lozano, M.D. (María Dolores), Manzano, R.G. (Ramón G.), Montuenga-Badia, L.M. (Luis M.), Thunnissen, F.B. (Frederick B.), Toledo, G. (Gemma), Vicent, S. (Silvestre)   +7 more
core   +1 more source

The Role of miRNAs in Chicken Immune Regulation and Prospects for Disease‐Resistant Breeding

Animal Research and One Health, EarlyView.
A schematic workflow illustrating the screening of disease‐resistant miRNAs and the generation of miRNA‐based disease‐resistant chickens via PGC‐mediated germline genome editing. ABSTRACT MicroRNAs (miRNAs) are emerging as pivotal regulators of the immune system, playing a decisive role in shaping disease resistance in chicken.
Qiangzhou Wang, Weiran Wu, Qingqing Cai, Jiaxing Wang, Qi Gao, Muhammad Iftikhar, Yulin Bi, Hao Bai, Lihong Gu, Guobin Chang, Shihao Chen   +10 more
wiley   +1 more source