Results 91 to 100 of about 85,416 (247)

Peptide RL‐QN15 Regulates Functions of Epidermal Stem Cells to Accelerate Skin Wound Regeneration via the FZD8/β‐Catenin Axis

Exploration, EarlyView.
Amphibian‐derived peptide RL‐QN15 activates the Wnt/β‐catenin signaling pathway by interacting with the FZD8 membrane receptor, promoting epidermal stem cells proliferation, migration, stemness, and EMT processes, thus promoting skin wound healing.
Yuansheng Li, Qiuye Jia, Naixin Liu, Saige Yin, Junyuan Wang, Yujing Ding, Yuliu Yang, Ying Peng, Zeqiong Ru, Shaoyang Zhang, Bu'er Qi, Jun Sun, Li He, Ying Wang, Kun Guo, Xinwang Yang   +15 more
wiley   +1 more source

Repurposed Antimicrobial Combination Therapy: Tobramycin-Ciprofloxacin Hybrid Augments Activity of the Anticancer Drug Mitomycin C Against Multidrug-Resistant Gram-Negative Bacteria

Frontiers in Microbiology, 2019
The lack of therapeutic options to treat infections caused by multidrug-resistant (MDR) pathogens, especially Gram-negative bacteria, is apparent. Therefore, it is imperative to develop new strategies to address the problem of antimicrobial resistance ...
Ronald Domalaon, Derek Ammeter, Marc Brizuela, Bala Kishan Gorityala, George G. Zhanel, Frank Schweizer, Frank Schweizer   +6 more
doaj   +1 more source

A Comprehensive Review on Nutrition, Phytochemistry, Pharmacology and Food Application Perspectives of Bioactive Rich Superfruits

Future Postharvest and Food, EarlyView.
The review critically evaluated and compared the selected superfruit phytochemistry, their bioactive composition and the key health benefits majorly emphasizing the antioxidant potential. It has highlighted the translational challenges in formulating functional foods by addressing the issues related to delivery system, bioavailability mechanism and the
Sharath Kumar Nagaraja, Javid Iqbal Mir, Mahendra Kumar Verma, Aamir Hussain Dar   +3 more
wiley   +1 more source

Somatic cell reprogramming for Parkinson's disease treatment

Ibrain, Volume 11, Issue 1, Page 59-73, Spring 2025.
The fundamental purpose of cell reprogramming to treat Parkinson's disease is to generate dopaminergic neurons (DAN) and do transplantation. There are two ways to accomplish this. One method is to induce cells into induced DA neurons (iDAN) directly or to induce cells into induced pluripotent stem cells and ultimately into iDAN in vitro. Another option
Xiaozhuo Li, Kevin Fang, Fengping Wang
wiley   +1 more source

Cellular location and activity of Escherichia coli RecG proteins shed light on the function of its structurally unresolved C-terminus [PDF]

, 2014
RecG is a DNA translocase encoded by most species of bacteria. The Escherichia coli protein targets branched DNA substrates and drives the unwinding and rewinding of DNA strands.
Abd Wahab, Akeel A. Mahdi, Al-Deib, Amy L. Upton, Atkinson, Bachmann, Bernhardt, Bolt, Brendler, Briggs, Briggs, Buss, Christian J. Rudolph, Datsenko, David S. Milner, Gari, Geoffrey S. Briggs, Gregg, Gupta, Hong, Jaktaji, Jane I. Grove, Lau, Lecointe, Lesterlin, Lia, Lloyd, Lloyd, Lloyd, Machwe, Mahdi, Mahdi, Mahdi, Mahdi, Manosas, Marians, McGlynn, McGlynn, McGlynn, McGlynn, McGlynn, McGlynn, McGlynn, Michel, Parsons, Pomerantz, Ralf, Robert G. Lloyd, Rocha, Rudolph, Rudolph, Rudolph, Rudolph, Seigneur, Sharples, Shereda, Singleton, Sun, Trautinger, Tsaneva, Vincent, Waldminghaus, West, Whitby, Whitby, Whitby, Whitby, Zacharias, Zhang   +68 more
core   +2 more sources

Impact of organic pollutants on phenotype and gene expression in human breast cancer cells

Journal of Applied Toxicology, EarlyView.
ABSTRACT Human exposure to industrial chemical compounds is widespread and, although often beneficial, prolonged contact may contribute to disease development, including cancer. While many studies have shown organic pollutants (OP) are cytotoxic, few have explored how long‐term exposure alters cell phenotype.
Camila Confortin, Heloisa Amancio, Jessica Zablocki da Luz, Aliciane de Almeida Roque, Tugstênio Lima de Souza, José Eduardo Vargas, Ciro Alberto de Oliveira Ribeiro, Francisco Filipak Neto   +7 more
wiley   +1 more source

Mussel eggs as indicators of mutagen exposure in coastal and estuarine environments [PDF]

, 1994
The aim of this study was to develop a short-term genotoxicity assay for monitoring the marine environment for mutagens. Based on the developing eggs and embryos of the marine mussel Mytilus edulis, an important pollution indicator species, the test ...
Dixon, D.R., Pascoe, P.L
core  

Autophagy Plays a Suppressive Role in Bladder Tumor Formation in an Orthotopic Mouse Model and Bladder Cancer Patient Specimens

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Autophagy plays either a suppressing or promoting role during tumor development. Clarifying the role of autophagy in bladder tumorigenesis both in vitro and in vivo is crucial for developing novel therapeutic strategies through manipulating autophagy activity.
Wan‐Ting Kuo, Chin‐Chen Pan, Yi‐Wen Liu, Nan‐Haw Chow, Hong‐Lin Cheng, Shan‐Ying Wu, Sheng‐Hui Lan, Chih‐Peng Chang, Hsiao‐Sheng Liu   +8 more
wiley   +1 more source

Intravesical Bacillus Calmette-Guérin versus mitomycin C for Ta and T1 bladder cancer: Abridged summary of the Cochrane Review [PDF]

Investigative and Clinical Urology, 2020
Stefanie Schmidt , Frank Kunath , Bernadette Coles , Desiree Louise Draeger , Laura-Maria Krabbe , Rick Dersch , Samuel Kilian, Katrin Jensen , Philipp Dahm , Joerg J Meerpohl   +9 more
doaj   +1 more source

Prevention of Intraabdominal Adhesions: An Experimental Study Using Mitomycin-C and 4% Icodextrin

Balkan Medical Journal, 2017
Background: Intraabdominal adhesions remain a significant cause of morbidity and mortality. Moreover, intraabdominal adhesions can develop in more than 50% of abdominal operations.
Murat Urkan, İsmail Hakkı Özerhan, Aytekin Ünlü, Mehmet Fatih Can, Erkan Öztürk, Armağan Günal, Gökhan Yağcı   +6 more
doaj   +1 more source