Results 111 to 120 of about 85,416 (247)

A phase II study of capecitabine and oxalplatin combination chemotherapy in patients with inoperable adenocarcinoma of the gall bladder or biliary tract [PDF]

, 2016
Background: Advanced biliary tract carcinomas are associated with a poor prognosis, and palliative chemotherapy has only modest benefit. This multi-centre phase II study was conducted to determine the efficacy of capecitabine in combination with ...
E. Soulis, F. Y. Coxon, J. S. Graham, K. Boyd, L. R. Wall, M. Highley, M. M. Eatock, P. Bützberger-Zimmerli, S. Harden, T. R. J. Evans, T. S. Maughan   +10 more
core   +1 more source

Anterior chamber flare and central macular thickness after trabeculectomy versus after phacoemulsification

Acta Ophthalmologica, EarlyView.
Abstract Purpose To compare the inflammatory response in the eye after trabeculectomy to after phacoemulsification, focusing on anterior chamber flare (AC flare) and central macular thickness (CMT). Methods Data from 436 participants in two randomized controlled trials were analysed.
Yasmeen Ahmed, Jesper Høiberg Erichsen, Afrouz Ahmadzadeh, Lars Morten Holm, Line Kessel, Daniella Bach‐Holm   +5 more
wiley   +1 more source

Can Epirubicin Be Used in Laryngology Practice Like Mitomycin? An Experimental and Pioneering Study [PDF]

Iranian Journal of Otorhinolaryngology
Introduction: Epirubicin and mitomycin-C share similar mechanisms of action, with both exhibiting antiproliferative effects by inhibiting DNA and protein synthesis.
Erdem Koroglu, Selahattin Genc, Serdar Baser, Ferit Bayakır, Ahmet Eruyar, Busra Bayrak   +5 more
doaj   +1 more source

Simple one-pot fabrication of ultra-stable core-shell superparamagnetic nanoparticles for potential application in drug delivery [PDF]

, 2012
Ultrastable superparamagnetic core-shell nanoparticles of average diameter 80 nm have been fabricated via a simple one-pot method involving superparamagnetic iron oxide nanoparticles (SPIONs) core ([similar]50 nm in diameter) and lipid bilayer shell by ...
Al-Jamal, Allen, Brahler, Bruce, Chetoni, Cheung, De Cuyper, Gabizon, Gaihre, Goodwin, Gupta, Hou, Jarrett, Juliano, Kim, Langer, Laurent, Liu, Mahmoudi, Mahmoudi, Mahmoudi, Mahmoudi, Mahmoudi, Mart, Massart, Meincke, Mezei, Pankhurst, Pauser, Perez, Philipse, Poste, Pradhan, Prozorov, Sasaki, Sen, Sen, Sen, Sharifi, Soenen, Soenen, Tartaj, Tokunaga, Zalipsky   +43 more
core   +1 more source

Inhibition of Fibroblast Activation Protein‐α Ameliorates Intervertebral Disc Degeneration via Reduced Vascular Invasion in Cartilage Endplate

Cell Proliferation, EarlyView.
Schematic illustration showing that FAP‐α promoted angiogenesis, cytokine release and ECM degradation in the CEP degeneration of the intervertebral disc through upregulating the PI3K/Akt/HIF‐1α/VEGFA pathway. ABSTRACT Intervertebral disc degeneration (IDD) is a primary cause of low back pain, with the development of new blood vessels being a key ...
Hao‐Wei Xu, Sheng‐Jie Chang, Shuo Wang, Xiao‐Wei Liu, Shan‐Jin Wang   +4 more
wiley   +1 more source

Detection Of DNA Damage By Use Of Escherichia Coli Carrying recA\u27::lux, uvrA\u27::lux, And alkA\u27::lux Reporter Plasmids [PDF]

, 1997
Plasmids were constructed in which DNA damage-inducible promoters recA, uvrA, and alkA from Escherichia coli were fused to the Vibrio fischeri luxCDABE operon. Introduction of these plasmids into E. coli allowed the detection of a dose-dependent response
Belkin, S., LaRossa, R. A., Smulski, D. R., Van Dyk, T. K., Vollmer, Amy Cheng   +4 more
core   +1 more source

Surgical excision of melanomas in the anal region and reconstruction of the anus in 11 horses

Equine Veterinary Education, EarlyView.
Summary This case report describes the surgical excision of large perianal and perineal melanomas, and reconstruction of the anus in 11 grey horses. Four horses had a history of painful defaecation or urination due to extensive tumours. Seven horses had no clinical signs at the time of admission but had rapidly growing nodules around the anus with ...
F. Somm, A. E. Fürst, M. A. Jackson
wiley   +1 more source

Repurposing Mitomycin C in Combination with Pentamidine or Gentamicin to Treat Infections with Multi-Drug-Resistant (MDR) Pseudomonas aeruginosa

Antibiotics
The aims of this study were (i) to determine if the combination of mitomycin C with pentamidine or existing antibiotics resulted in enhanced efficacy versus infections with MDR P.
Elin Svedholm, Benjamin Bruce, Benjamin J. Parcell, Peter J. Coote   +3 more
doaj   +1 more source

Limited roles of the miR‐17‐92 cluster in the regulation of T‐cell apoptosis

The FEBS Journal, EarlyView.
The pro‐apoptotic protein BIM shapes T‐cell survival and function, but how it is regulated remains unclear. In a mouse model lacking direct miR‐17‐92:Bim interactions, we observed a moderate reduction in Th17 CD4+ T cells. BIM levels were modestly increased in double‐positive thymocytes and naive CD8+ T cells, but this did not affect overall T‐cell ...
Katharina Hoppe, Johannes Woelk, Julia Benz, Sarah Spoeck, William J. Olson, Andreas Villunger, Natascha Hermann‐Kleiter, Verena Labi   +7 more
wiley   +1 more source

GCN2 in proteostasis: structural logic, signalling networks and disease

The FEBS Journal, EarlyView.
Threats to protein synthesis activate the kinase GCN2, initiating the integrated stress response (ISR). GCN2 is triggered by stalled ribosomes and uncharged tRNAs, which accumulate when amino acids are scarce. The ISR adjusts cellular physiology by promoting redox balance, protein quality control, and mitochondrial optimisation.
JiaYi Zhu, Stefan J. Marciniak
wiley   +1 more source