Results 121 to 130 of about 124,344 (344)

Distinct DNA repair pathways involving RecA and nonhomologous end joining in Mycobacterium smegmatis [PDF]

open access: yes, 2006
Mycobacterium smegmatis was used to study the relationship between DNA repair processes involving RecA and nonhomologous end joining (NHEJ). The effect of gene deletions in recA and/or in two genes involved in NHEJ (ku and ligD) was tested on the ability
Anna Brzostek   +39 more
core   +1 more source

Imatinib decreases germ cell survival and germline stem cell proliferation in rodent testis ex vivo and in vitro

open access: yesAndrology, EarlyView.
Abstract Background Imatinib and dasatinib are tyrosine kinase inhibitors (TKIs) increasingly used to treat several diseases in both children and adults at fertile age. We have previously shown that imatinib has adverse effects on developing testis, and imatinib‐treated male patients have been reported to have reduced sperm counts.
Anna Eggert   +10 more
wiley   +1 more source

Tuberculosis vaccine strain _Mycobacterium bovis_ BCG Russia is a natural _recA_ mutant [PDF]

open access: yes, 2008
The current tuberculosis vaccine is a live vaccine derived from _Mycobacterium bovis_ and attenuated by serial _in vitro_ passaging. All vaccine substrains in use stem from one source, strain Bacille Calmette-Guérin.
Erik C. Boettger   +2 more
core   +1 more source

DNA double strand breaks but not interstrand crosslinks prevent progress through meiosis in fully grown mouse oocytes [PDF]

open access: yes, 2012
There is some interest in how mammalian oocytes respond to different types of DNA damage because of the increasing expectation of fertility preservation in women undergoing chemotherapy.
Julie A. Merriman   +4 more
core   +3 more sources

Mitomycin-C Use in Ophthalmology

open access: yes, 2013
Mitomycin-C is a chemotherapeutic drug that acts by inhibiting DNA synthesis. Its use and application in ophthalmology has been increasing in recent years because of its mandatory effects on wound healing.
Parul Singh
semanticscholar   +1 more source

Prognosis and determinants of survival after orbital exenteration for conjunctival melanoma: Experiences from a Dutch Referral Centre

open access: yesActa Ophthalmologica, EarlyView.
Abstract Purpose To assess the prognosis and determinants of survival after orbital exenteration in patients with conjunctival melanoma (CoM). Methods In a retrospective study, 27 consecutive patients who underwent exenteration for CoM from 2001 to 2023 were included.
David Chetroiu   +7 more
wiley   +1 more source

A study of oral metformin for the intravesical treatment of non‐muscle‐invasive bladder cancer

open access: yesBJU International, EarlyView.
Objectives To evaluate the effect of metformin on non‐muscle‐invasive bladder cancer (NMIBC) marker lesions. Patients and methods A phase II, open‐label, multicentre, marker lesion trial using oral metformin in patients with primary or recurrent, multiple, low‐grade Ta‐T1 NMIBC was conducted. After transurethral resection for histological confirmation,
Jons W. van Hattum   +12 more
wiley   +1 more source

Home - About - Disclaimer - Privacy