Reversible inhibition of mammalian tubulin assembly in vitro and effects in Saccharomyces cerevisiae D61.M by mitomycin C [PDF]
, 2017 Gaulden reported a novel and unexpected mitomycin C (MMC) effect, namely a pronounced retardation of very late prophase and loss of chromosome orientation in neuroblasts of the grasshopper Chortophaga viridifasciate.
Albertini, S. +2 more
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Advanced Science, EarlyView.This study presents an intravesical delivery strategy of ferroptosis‐ and immunity‐inducing nanozyme‐loaded thermoresponsive hydrogels (FMCC@PNH) for enhanced bladder cancer therapy. Abstract Current intravesical therapies for bladder cancer after resection are limited by poor tissue penetration, off‐target effects, and insufficient efficacy.
Yongnan Jiang +11 more
wiley +1 more source
A comparative study on the anti-angiogenic effects of DNA-damaging and cytoskeletal-disrupting agents [PDF]
, 2018 The discovery of molecules with anti-angiogenic properties has led to promising new strategies for the treatment of diseases characterized by excessive new vessel growth, such as cancer and haemangioma.
Mabeta, Peace, Pepper, Michael
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Structural characterization of the mitomycin 7‐ O ‐methyltransferase [PDF]
, 2011 Mitomycins are quinone‐containing antibiotics, widely used as antitumor drugs in chemotherapy. Mitomycin‐7‐ O ‐methyltransferase (MmcR), a key tailoring enzyme involved in the biosynthesis of mitomycin in Streptomyces lavendulae , catalyzes the 7‐ O ...
Bingman, Craig A. +7 more
core +1 more source
Advanced Science, EarlyView.This study presents a vascularized 3D tumor model to investigate immune–stromal–tumor interactions under allogeneic PBMC perfusion. While immune cells induced tumor shrinkage, they also promoted vascular regression, stromal activation, and cancer cell invasion.
Alexandra Raab +8 more
wiley +1 more source
Differential Toxicity of DNA Adducts of Mitomycin C [PDF]
, 2010 The clinically used antitumor agent mitomycin C (MC) alkylates DNA upon reductive activation, forming six covalent DNA adducts in this process. This review focuses on differential biological effects of individual adducts in various mammalian cell ...
Bargonetti, Jill +2 more
core +4 more sources
Cellular Identity Crisis: RD3 Loss Fuels Plasticity and Immune Silence in Progressive Neuroblastoma
Advanced Science, EarlyView.Researchers discovered that therapy‐induced loss of RD3 protein in neuroblastoma triggers a dangerous shift: cancer cells become more stem‐like, invasive, and resistant to treatment while evading immune detection. RD3 loss suppresses antigen presentation and boosts immune checkpoints, creating an immune‐silent environment.
Poorvi Subramanian +7 more
wiley +1 more source
Association pattern of reciprocal translocations induced by chemicals and ionizing radiation in mouse germ cells: a comparison between single and combined treatments [PDF]
, 2011 The similarity degree of chemical, ionizing radiation, and combined treatments of chemical plus ionizing radiation in their capacity to induce reciprocal translocations was analyzed by means of multivariate analysis techniques on mice germ cells.
de Luca, Julio Cesar +2 more
core +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.Limited evidence exists synthesizing the risk of acute kidney injury (AKI) associated with the concomitant administration of multiple nephrotoxic drugs, and even less examining the concept of nephrotoxic burden. The objective of this scoping review was to (1) identify definitions of nephrotoxic burden; (2) methods used to quantify (use of calculations)
Wafa Alatawi +6 more
wiley +1 more source
Comparison of Efficacy of Hyperthermic Intraperitoneal Chemotherapeutics Mitomycin C versus Oxaliplatin In Experimental Colorectal Peritoneal Metastasis Model [PDF]
, 2023 Berke Manoğlu +6 more
openalex +1 more source