Results 41 to 50 of about 13,879 (218)

Immunosuppression and Surgery‐Free Interval in Granulomatosis With Polyangiitis Airway Stenosis

The Laryngoscope, EarlyView.
Subglottic and tracheal stenosis are severe manifestations of granulomatosis with polyangiitis (GPA) that often require both endoscopic intervention and systemic immunosuppression. Rituximab may help stabilize GPA‐related airway disease by prolonging the interval between endoscopic procedures and delaying relapse.
Sydney J. Torres, Andrew J. Neevel, Julia A. Ford, Lawrence Kashat, Norman D. Hogikyan, Robbi A. Kupfer, Robert J. Morrison   +6 more
wiley   +1 more source

Diagnosis and Management of Isolated Laryngeal Sarcoidosis: A Systematic Review

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objective This study reviews the existing literature on patients diagnosed with sarcoidosis isolated to the larynx to improve our understanding of the diagnosis and management of this rare condition. Data Sources Embase, PubMed, Web of Science.
Raj Malhotra, Joseph Celidonio, Nicholas Hamilton, Alexandra Filipkowski, Kenneth Yan, Rachel Kaye   +5 more
wiley   +1 more source

Mitomycin alkaloids: synthetic studies [PDF]

, 2009
2009 Spring.Includes bibliographical references.Documented herein are efforts towards the first asymmetric total synthesis of the mitomycin family of natural products.
Gubler, Daniel Alan
core  

Stabilized Extracellular Vesicle Formulations for Inhalable Dry Powder Development

Small, EarlyView.
Extracellular vesicles (EVs) hold promise for chronic obstructive pulmonary disease (COPD) treatment but face challenges with storage and delivery. This study demonstrates the stabilization of lung fibroblast‐derived EVs using inulin, enabling freeze‐drying and spray‐drying.
Eva M. Jansen, Luke van der Koog, Robin A.B. Elferink, Karim Rafie, Anika Nagelkerke, Reinoud Gosens, Henderik W. Frijlink, Wouter L.J. Hinrichs   +7 more
wiley   +1 more source

DNA Adducts of Decarbamoyl Mitomycin C Efficiently Kill Cells without Wild-Type p53 Resulting from Proteasome-Mediated Degradation of Checkpoint Protein 1 [PDF]

, 2009
The mitomycin derivative 10-decarbamoyl mitomycin C (DMC) more rapidly activates a p53independent cell death pathway than mitomycin C (MC). We recently documented that an increased proportion of mitosene1-β-adduct formation occurs in human cells treated ...
Abbas T., Arriola E. L., Ayala-Torres S., Bargonetti J., Bargonetti J., Ben-Yehoyada M., Boamah E. K., Carrassa L., Castedo M., Chan T. A., Cho S. H., Collis S. J., Deng C., Didier C., Dixon H., Dronkert M. L., Edinger A. L., Enders G. H., Geacintov N. E., Hammond E. M., Hammond E. M., Harris S. L., Hirose Y., Hollstein M., Hollstein M., Huang X., Iyer V. N., Johnstone R. W., Kawabe T., Kennedy K. A., Kinoshita S., Kumar S., Levine A. J., Merry C., Mukhopadhyay U. K., Myers K., Norman D., Osborn A. J., Palom Y., Paz M. M., Rockwell S., Russell K. J., Santos J. H., Sastry M., Shen X., Sidi S., Sugiyama K., Syljuasen R. G., Tomasz M., Tomasz M., Tomasz M., Van Houten B., Waldman T., Wang J. L., Wang Z., Yu J., Zhang Y. W., Zhang Y. W., Zhang Y. W., Zhao H., Zou L.   +60 more
core   +4 more sources

Bioengineered Bacterial Vesicles and Biomimetic Hybrids Eliminate Biofilms and Balance the Gut Microbiome

Small, EarlyView.
Biomimetic nanocarriers based on liposomes and Myxobacteria outer‐membrane vesicles (OMVs) are effective antibiotic delivery systems. Hybrids have a higher drug loading and can target intracellular pathogens, while OMVs evade immune clearance. Biomimetic nanoantibiotics effectively eliminate the biofilms of Gram‐negative bacteria. Besides, Myxobacteria
Leila Pourtalebi Jahromi, Benedikt Kronast, Jennifer Munkert, Lorenzo Sana, Marcus Koch, Heike Danzer, Sirka Dormeyer, Shuhan Jiang, Fabian Herrmann, Matthias Weiler, Anna Kashkanova, Vahid Sandoghdar, Mario M. Zaiss, Gregor Fuhrmann   +13 more
wiley   +1 more source

Preclinical Toxicity Screening of Sodium Dodecanoyloxybenzenesulfonate (LOBS) as a New Alternative Biocide Using In Vitro and In Vivo Models

Environmental Toxicology, EarlyView.
ABSTRACT Sodium hypochlorite is a well‐established biocide extensively used in both living and industrial environments; however, exposure to it or improper handling can harm the human body and the environment. Thus, safer alternatives to sodium hypochlorite are required.
Seung Eui Min, Seunghee Oh, Min Seong Jang, Kang‐Hyun Han   +3 more
wiley   +1 more source

Development of miracle medicines from sialic acids [PDF]

, 2011
Sialic acids are electronegatively charged C9-sugars and are considered to play important roles in higher animals and some microorganisms. Denoting their significance, understanding and exploiting the complexity of the sialic acids has been referred to ...
ANAZAWA K, FURUHATA K, FURUHATA K, FURUHATA K, FURUHATA K, FURUHATA K, FURUHATA K, FURUHATA K, FURUHATA K, HAGA N, HAGA N, Ito, J., Kato, T., Okumura-Noji, K., Kato, T., Ito, J., Tanaka, R., Suzu, KIJIMA-SUDA I, LI S S, NAGAOKA SHIGERU, NAKAMURA M, NAKAMURA M, NAKAMURA M, NAKAMURA M, NAKAMURA M, NAKAMURA M, OGURA H, OGURA HARUO, Ogura, H. and Takeda, K., Ogura, H., Kobayashi, T., Shimizu,, SATO S, SATO S, SATO S, Schauer, R., SUGIYAMA N, SUN X-L, SUZUKI K, Suzuki, M., Suzuki, A., Yamakawa, T, TAKAMURA M, Tanaka, Y., Han, H., Hagishita, T.,, TSUBOYAMA K, TSUBOYAMA K, von Itzstein, M., Wu, W.-Y., Kok, G, WAKI H   +39 more
core   +2 more sources

Clinical outcomes of the PAUL glaucoma implant in primary open‐angle and pseudoexfoliative glaucoma eyes after failed glaucoma surgeries

Acta Ophthalmologica, EarlyView.
Abstract Purpose This study assesses the PAUL® glaucoma implant (PGI) in primary open angle glaucoma (POAG) and pseudoexfoliative glaucoma (PEXG) after failed glaucoma surgery. Given PEXG's more aggressive nature, limited research exists on PGI outcomes in this subgroup. This study aims to compare PGI's efficacy and safety in both conditions. Methods A
Constance Liegl, Leonie Bourauel, Benjamin Aretz, Diana Samarghitan, Wolfgang Walz, Michael Petrak, Frank G. Holz, Raffael Liegl, Karl Mercieca   +8 more
wiley   +1 more source

Blindness and prognostic factors after trabeculectomy with mitomycin C in patients with open‐angle glaucoma with long‐term follow‐up

Acta Ophthalmologica, EarlyView.
Abstract Purpose To determine the long‐term blindness rate and related prognostic factors in eyes with open‐angle glaucoma after trabeculectomy using adjunctive mitomycin C (MMC). Methods The retrospective cohort study included 714 eyes from 714 patients with open angle glaucoma who underwent trabeculectomy using MMC.
Masato Matsuo, Akira Sawada, Taishi Miyase, Masayuki Inuzuka, Masaomi Kubota, Tetsuya Yamamoto   +5 more
wiley   +1 more source