Results 121 to 130 of about 359,876 (283)

Xanthatin Targets CISD1 to Drive Ferroptosis and Mitophagy as a Dual Anticancer Strategy in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
Triple‐negative breast cancer has a poor prognosis. Xanthatin directly targets and degrades CISD1, triggering ferroptosis through iron dysregulation. The concurrently activated mitophagy synergistically amplifies ferroptotic cell death. Xanthatin also demonstrates potent in vivo anti‐tumor efficacy with minimal toxicity, highlighting its therapeutic ...
Qinwen Liu, Haojie Chen, Xiang Li, Jingxin Liu, Yiwen Li, Zhenyi Shi, Shenshen Guo, Qingfeng Du, Aiping Lu, Daogang Guan   +9 more
wiley   +1 more source

The politics of hero myth in President Jokowi's biopic film (2013)

Satwika: Kajian Ilmu Budaya dan Perubahan Sosial
Among the prominent Indonesian biographical films concerning "national heroes" that emerged in the 2010s is "Jokowi" (2013). This film narrates the life of Joko Widodo (Jokowi), who was then serving as the Governor of Jakarta and was released a month ...
Muhammad Dzaky Abdullah, Ari J. Adipurwawidjana, Muhamad Adji   +2 more
doaj   +1 more source

Mito y pedagogía

Praxis & Saber, 2015
<p>En estas primeras décadas del siglo XXI poner en relación los vocablos «mito» y «pedagogía» no es ningún despropósito, especialmente si se parte de la base que el mito fundamentalmente es narración en acto. Ha de subrayarse el hecho de que, desde el nacimiento hasta la muerte, el narrar es —debería ser— un factor constituyente en todas las ...
openaire   +4 more sources

Cell‐Free DNA‐Based Theranostics for Inflammatory Disorders

Advanced Science, EarlyView.
Summary on the dual potential of cfDNA as biomarkers and therapeutic targets for inflammatory disorders. Figure was created with BioRender.com. ABSTRACT Inflammatory disorders are characterized by immune‐mediated inflammatory cascades that can affect multiple organs.
Jiatong Li, Yumei Wang, Xiaoxi Fan, Miao Xu, Jiawen Li, Wenfei Tan, Jianxiang Zhang, Heran Li   +7 more
wiley   +1 more source

“El día menos pensado”. Historias, sueños, trolas y pesadillas de un trabajo tan perro que si te falta te mueres y si no, también [PDF]

, 2018
Trabajar en creatividad está rodeado de mitos y mentiras que ofrecen una visión romántica de la profesión. Quizás no se trata de desmontar estos mitos, sino de abrir el ángulo de visión para ver lo oculto, lo innombrado y así crear una visión de conjunto
Titos, David
core  

ADAMTS9‐AS2 Disrupts Docetaxel‐Resistance in Castration‐Resistant Prostate Cancer via Stemness Suppression and Ferroptosis Induction

Advanced Science, EarlyView.
This study uncovered a dual‐track mechanism by which ADAMTS9‐AS2 overcame chemoresistance in CRPC: suppressing cancer stemness through the FOXF2/TGF‐β2 pathway, and triggering ferroptosis via competitive SLC7A11 sequestration. Polymeric materials co‐targeting these vulnerabilities further boost docetaxel sensitivity, highlighting a compelling strategy ...
Ji Liu, Yan Gao, Yadong Guo, Junfeng Zhang, Wentao Zhang, Zhuoran Gu, Haotian Chen, Chengqi Jin, Peng Luo, Shiyu Mao, Yajuan Hao, Shuo Shi, Xudong Yao   +12 more
wiley   +1 more source

Clásica y moderna : Un acercamiento a la poética de Ezra Pound [PDF]

, 2011
Ezra Pound (1885-1972) mantuvo una constante y compleja relación con las tradiciones clásicas y medievales. Desde Personae (1909), de ascendencia ovidiana, hasta el Homage to Sextus Propercius (1919), pasando por su recurrencia sistemática a mitos y ...
Gonzo, Luis Angel
core   +1 more source

Mitochondrial Transplantation as a Therapeutic Strategy for Inherited Mitochondrial Diseases

Advanced Science, EarlyView.
Mitochondrial transplantation (MTx) offers a promising therapeutic avenue for mitochondrial diseases. This review comprehensively evaluates MTx, differentiating its feasibility for mtDNA‐ and nDNA‐based disorders. It examines its potential for genetic correction, alongside inherent limitations, technical challenges, and crucial ethical considerations ...
Parmeshar Singh, Amir Tahavvori, Cyrus E. Kuschner, Blanca B. Espin, Jacob Kazmi, Sofhia V. Ramos, Tai Yin, Kei Hayashida, Kanako Ito‐Hagiwara, Yusuke Endo, Keitaro Yoshioka, Jun Hagiwara, Avijot Sohi, Alisha Oropallo, Ghania Haddad, Timmy Li, Lance B. Becker, Junhwan Kim   +17 more
wiley   +1 more source

Mitos y bulos de la alimentación [PDF]

, 2019
La alimentación y la nutrición son temas de actualidad integrados en las conversaciones de la sociedad. El problema reside en la existencia de mucha información falsa, que recibe el nombre de mito y que la población no sabe diferenciar de la que es veraz.
Presencio Domínguez, Javier
core  

Illuminating Mitochondrial RNA G‐Quadruplexes as Structural Brakes on RNA Granule Assembly and OXPHOS

Advanced Science, EarlyView.
A new fluorescent probe, MitoQUMA, brings mitochondrial RNA G‐quadruplexes (mtRNA G4s) into view in live cells. This tool reveals that excessive mtRNA G4 formation halts mitochondrial RNA granule (MRG) assembly, opposite to the phase‐separation role of cytoplasmic RNA G4s. A chemical genetic screen further identifies a Wnt/β‐catenin–GRSF1–mtRNA G4 axis
Gui‐Xue Tang, Jia‐Tong Yan, Mao‐Lin Li, Cui Zhou, Jian Wang, Shuo‐Bin Chen, Zhi‐Shu Huang, Jia‐Heng Tan   +7 more
wiley   +1 more source