Results 91 to 100 of about 46,698 (168)

Stochastic modelling of chromosomal segregation : errors can introduce correction [PDF]

, 2014
Cell division is a complex process requiring the cell to have many internal checks so that division may proceed and be completed correctly. Failure to divide correctly can have serious consequences, including progression to cancer.
Roitershtein, Alexander, Matzavinos, Anastasios, Voller, Zachary, Liu, Sijia, Shtylla, Blerta, Chaplain, Mark A.J., Chaplain, Mark A.J.; id_orcid   +6 more
core   +1 more source

Mitotic progression, arrest, exit or death relies on centromere structural integrity, rather than de novo transcription

eLife, 2018
Recent studies have challenged the prevailing dogma that transcription is repressed during mitosis. Transcription was also proposed to sustain a robust spindle assembly checkpoint (SAC) response.
Marco Novais-Cruz, Maria Alba Abad, Wilfred FJ van IJcken, Niels Galjart, A Arockia Jeyaprakash, Helder Maiato, Cristina Ferrás   +6 more
doaj   +1 more source

Deficiency of mastl, a mitotic regulator, results in cell detachment from developing tissues of zebrafish embryos

Frontiers in Cell and Developmental Biology
To form tissues with unique functions and structures, it is important that the cells that comprise them maintain physical contact. On the other hand, with each mitosis, drastic changes in cell shapes, cell adhesion, and cytoskeletal architecture may ...
Hideko Utsumi, Hideko Utsumi, Taijiro Yabe, Taijiro Yabe, Taijiro Yabe, Sumito Koshida, Sumito Koshida, Sumito Koshida, Akira Yamashita, Akira Yamashita, Akira Yamashita, Shinji Takada, Shinji Takada, Shinji Takada   +13 more
doaj   +1 more source

Mitotic centromere-associated kinesin (MCAK) : a potential cancer drug target [PDF]

, 2011
The inability to faithfully segregate chromosomes in mitosis results in chromosome instability, a hallmark of solid tumors. Disruption of microtubule dynamics contributes highly to mitotic chromosome instability.
Yuan, Juping, Louwen, Frank, Sanhaji, Mourad, Friel, Claire T., Wordeman, Linda   +4 more
core   +1 more source

Unveiling an Arpp-19 phosphorylation switch that grants chromosome stability

Communications Biology
During cell division, the onset of mitosis is granted by activation of cyclin B-dependent kinase 1 (Cdk1), master mitotic kinase, coordinated with inactivation of Cdk1-counteracting phosphatases.
Angela Flavia Serpico, Caterina Pisauro, Asia Trano, Domenico Grieco   +3 more
doaj   +1 more source

Phosphorylated ERK5/BMK1 transiently accumulates within division spindles in mouse oocytes and preimplantation embryos

Folia Histochemica et Cytobiologica, 2011
MAP kinases of the ERK family play important roles in oocyte maturation, fertilization, and early embryo development. The role of the signaling pathway involving ERK5 MAP kinase during meiotic and mitotic M-phase of the cell cycle is not well known. Here,
Maria A. Ciemerych, Jacek Z. Kubiak, Aude Pascal, Zuzanna Maciejewska   +3 more
doaj   +1 more source

Genome safeguarding during mitosis [PDF]

Safeguarding the genome during mitosis is essential for the accurate transmission of genetic information. While canonical DNA repair pathways are active during interphase, their suppression in mitosis prevents errors that could disrupt chromosome ...
Audrey, Anastasia; id_orcid
core   +1 more source

A Subphase-Labeled Mitotic Dataset for AI-powered Cell Division Analysis

Scientific Data
Mitosis detection represents a critical task in digital pathology, as it plays an important role in the tumor grading and prognosis of patients. Manual determination is a labor-intensive task for practitioners with high interobserver variability, thus ...
Zsanett Zsofia Ivan, Dominik Hirling, Istvan Grexa, Jonas Ammeling, Csaba Molnar, Tamas Micsik, Katalin Dobra, Levente Kuthi, Farkas Sukosd, Janos Fillinger, Judit Moldvay, Erika Toth, Marc Aubreville, Vivien Miczan, Peter Horvath   +14 more
doaj   +1 more source

Ki-67 and CDK1 control the dynamic association of nuclear lipids with mitotic chromosomes

Journal of Lipid Research
Nuclear lipids play roles in regulatory processes, such as signaling, transcriptional regulation, and DNA repair. In this report, we demonstrate that nuclear lipids may contribute to Ki-67-regulated chromosome integrity during mitosis.
Hsiao-Tang Hu, Ueh-Ting Tim Wang, Bi-Chang Chen, Yi-Ping Hsueh, Ting-Fang Wang   +4 more
doaj   +1 more source

Poly(ADP-ribosyl)ation is recognized by ECT2 during mitosis

, 2014
Poly(ADP-ribosyl)ation is an unique posttranslational modification and required for spindle assembly and function during mitosis. However, the molecular mechanism of poly(ADP-ribose) (PAR) in mitosis remains elusive.
Mo Li (43239), Chunjing Bian (152551), Xiaochun Yu (152572)   +2 more
core   +1 more source