Results 91 to 100 of about 195,442 (311)
Advanced Science, EarlyView.This study investigates how CTCs survive varying shear stress during hematogenous metastasis. We uncover a self‐protection mechanism, by which non‐adherent CTCs adapt to high shearing milieu through accumulated cytoplasmic myosin‐mediated disruption of myosin‐actin binding, attenuating force transmission into chromatin to protect CTCs from shear ...
Cunyu Zhang +10 more
wiley +1 more source
PLoS GeneticsStem and progenitor cell mitosis is essential for tissue development and homeostasis. How these cells ensure proper chromosome segregation, and thereby maintain mitotic fidelity, in the complex physiological environment of a living animal is poorly ...
Eric Cheng, Ran Lu, Abigail R Gerhold
doaj +1 more source
eLife, 2013 Experiments in Xenopus embryo extracts reveal that changes in cellular biochemistry cause mitotic spindles to decrease in size over the course of early development.
Daniel Needleman
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The coordination of nuclear envelope assembly and chromosome segregation in metazoans
Nucleus, 2020 The nuclear envelope (NE) is composed of two lipid bilayer membranes that enclose the eukaryotic genome. In interphase, the NE is perforated by thousands of nuclear pore complexes (NPCs), which allow transport in and out of the nucleus. During mitosis in
Shiwei Liu, David Pellman
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Advanced Science, EarlyView.Molecular, genetic, virological, and biochemical analysis in combination with global proteome and phosphoproteome profiling and functional assays were applied to study the role of PR130 in the context of HSV‐1 replication. The observations reveal that host‐intrinsic mechanisms regulate HSV‐1 replication and highlight PR130 as a susceptibility factor of
Johannes Jungwirth +10 more
wiley +1 more source
Splicing factors Sf3A2 and Prp31 have direct roles in mitotic chromosome segregation
eLife, 2018 Several studies have shown that RNAi-mediated depletion of splicing factors (SFs) results in mitotic abnormalities. However, it is currently unclear whether these abnormalities reflect defective splicing of specific pre-mRNAs or a direct role of the SFs ...
Claudia Pellacani +9 more
doaj +1 more source
Advanced Science, EarlyView.Inspired by natural amino acid polymer‐melanin systems, this study strategically incorporated tellurocysteine to develop advanced radiation‐shielding materials. This approach transformed the primary interaction mechanism between melanin‐based materials and incident photons from Compton scattering to the photoelectric effect. Tellurocysteine‐polymerized
Wei Chen +6 more
wiley +1 more source
, 2016 Presents a cultured newt cell in late prophase. Chromosome condensation is well advanced, but the nuclear envelope is still visible at the periphery of the chromosomes.
Pickett-Heaps, Jeremy D. +1 more
core +1 more source
PHOSPHORYLATION CHANGES DURING EGG ACTIVATION AND ON REGULATORS OF THE FIRST EMBRYONIC CELL CYCLE IN DROSOPHILA [PDF]
, 2008 At the transition from oocyte to embryo, a quiescent mature oocyte is transformed in a short span of time to a rapidly dividing embryo. In the first two hours of Drosophila melanogaster embryogenesis there is very little transcription of the zygotic ...
Sackton, Katharine
core
Borealin : a novel chromosomal passenger required for stability of the bipolar mitotic spindle [PDF]
, 2004 The chromosomal passenger complex of Aurora B kinase, INCENP, and Survivin has essential regulatory roles at centromeres and the central spindle in mitosis. Here, we describe Borealin, a novel member of the complex.
Erich A. Nigg +26 more
core +1 more source