Results 161 to 170 of about 163,907 (337)

Unveiling the complexity of cellular senescence in cancers: From mechanism to therapeutic opportunities

open access: yesBMEMat, EarlyView.
This review highlights the complex roles of cellular senescence in cancer progression and suppression, discusses the mechanisms and regulatory pathways involved, and evaluates the efficacy of the “One‐Two punch” sequential treatment approach while addressing emerging challenges in this novel therapeutic strategy.
Qiuming Pan   +12 more
wiley   +1 more source

Mitosis in motion

open access: yesTrends in Cell Biology, 1996
Raff, J, Allan, V
openaire   +3 more sources

Cuproplasia and cuproptosis, two sides of the coin

open access: yesCancer Communications, EarlyView.
Abstract Copper is an essential micronutrient in the human body, mainly acting as a crucial cofactor required for a wide range of physiological processes across nearly all cell types. Recent advances revealed that tumor cells seize copper to fulfill their rapid proliferation, metastasis, immune evasion, and so on by reprogramming the copper regulatory ...
Kaizhong Lu   +4 more
wiley   +1 more source

Committing to mitosis

open access: yesThe Journal of Cell Biology, 2003
![Graphic][1] Ser 214 phosphorylation (red) keeps Cdc25C switched on only in mitotic cells (green). Fornace/MacmillanThere is a time for caution and a time for committing. For the cell cycle, a halt before mitosis is an appropriate response to ionizing radiation or inhibition of ...
openaire   +2 more sources

Interrogating Histone Acetylation and BRD4 as Mitotic Bookmarks of Transcription

open access: yesCell Reports, 2019
Summary: Global changes in chromatin organization and the cessation of transcription during mitosis are thought to challenge the resumption of appropriate transcription patterns after mitosis.
Vivek Behera   +13 more
doaj  

BOrg: A Brain Organoid-Based Mitosis Dataset for Automatic Analysis of Brain Diseases [PDF]

open access: yesarXiv
Recent advances have enabled the study of human brain development using brain organoids derived from stem cells. Quantifying cellular processes like mitosis in these organoids offers insights into neurodevelopmental disorders, but the manual analysis is time-consuming, and existing datasets lack specific details for brain organoid studies. We introduce
arxiv  

An Indole Dearomatization Strategy for the Synthesis of Pseudo‐Natural Products

open access: yesChemBioChem, Accepted Article.
The indole moiety is a privileged fragment that frequently populates existing bioactive compound collections. We describe the development of an indole‐dearomatization sequence and its application for library expansion of a collection of indole‐containing pseudo‐NPs.
Joseph G.F. Hoock   +13 more
wiley   +1 more source

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