Results 221 to 230 of about 329,783 (340)

The Contribution of Cholesterol and Squalene Synthase in Cancer: Molecular Mechanisms, Lipid Rafts and Therapeutic Approaches

Medicinal Research Reviews, EarlyView.
ABSTRACT A plethora of cellular signaling pathways are dysregulated in cancer cells, promoting carcinogenesis and migration. Cholesterol has recently been linked to cancer by several subcellular mechanisms, especially by its involvement in the formation of lipid rafts, which promote oncogenic signaling and cancer cell invasion. Squalene synthase (SQS),
Danai Mavridi, Theodora Katavati, Angeliki P. Kourounakis   +2 more
wiley   +1 more source

Motorized chromosome models of mitotic chromosome folding. [PDF]

Nat Commun
Cao Z, Du C, Hou Z, Wolynes PG.
europepmc   +1 more source

Human Cyclophilins—An Emerging Class of Drug Targets

Medicinal Research Reviews, EarlyView.
ABSTRACT Cyclophilins are a family of enzymes with peptidyl‐prolyl isomerase activity found in all cells of all organisms. To date, 17 cyclophilin isoforms have been identified in the human body, participating in diverse biological processes. Consequently, cyclophilins have emerged as promising targets for drug development to address a wide array of ...
Katarina Jurkova, Hana Navratilova, Kamil Musilek, Ondrej Benek   +3 more
wiley   +1 more source

Mitosis [PDF]

, 2020
openaire   +2 more sources

gRASping Depolarization: Contribution of RAS GTPases to Mitotic Polarity Clusters Resolution

Frontiers in Cell and Developmental Biology, 2020
Roberto Quadri, Sarah Sertic, Marco Muzi-Falconi   +2 more
doaj   +1 more source

Capturing aberrant cell behaviors producing defects in human embryos via live imaging. [PDF]

Sci Adv
Akizawa H, Domingo-Muelas A, Pardo-Figuerez M, Hernandez B, Ardestani G, Skory RM, Venturas M, Tetlak P, Bissiere S, Sakkas D, Simon C, Plachta N.   +11 more
europepmc   +1 more source

Genome-wide nucleosome profile during mitosis and meiosis in fission yeast

, 2011
Ignacio Soriano, Laura Marín, Luis Quintales, Francisco Antequera   +3 more
openalex   +1 more source

Regulatory mechanisms of reproduction in locusts and grasshoppers

New Plant Protection, EarlyView.
Regulatory networks composed of numerous coding and noncoding genes play crucial roles in the reproduction of locusts and grasshoppers. This review integrates mechanistic advances in reproductive regulation, highlighting environmentally adaptive pathways and providing prospective targets for eco‐friendly pesticides.
Jing He, Jiliang Wang, Xinran Wang
wiley   +1 more source

Association of oncogene mutations with clinical and histopathological characteristics in patients with metastatic melanoma. [PDF]

An Bras Dermatol
Quintiliano JA, Nunes AF, Pinheiro-Hubinger-Stauffer L.   +2 more
europepmc   +1 more source

Friends or foes? Polyploidy and competition in a grassland geophyte

Oikos, EarlyView.
Previous studies have suggested polyploids may possess a competitive advantage over diploids, due to their larger size, increased vigour or ability to better respond to abiotic stress. However, few studies have tested the effect of polyploidy on competitive ability directly, and only relatively recently has this oversight begun to be addressed. Here we
Damian Vaz de Sousa, Michelle Greve, Nicolette J. Taylor, Kenneth C. Oberlander   +3 more
wiley   +1 more source