Results 231 to 240 of about 380,556 (390)

Playing polo during mitosis: PLK1 takes the lead

open access: yesOncogene, 2017
Guillaume Combes   +3 more
semanticscholar   +1 more source

Single‐cell multi‐omics characterize colorectal tumors, adjacent healthy tissue and matched (tumor) organoids identifying CRC‐unique features

open access: yesInternational Journal of Cancer, EarlyView.
What's New? Patient‐derived organoids provide a promising platform for modeling colorectal cancer. The authors demonstrated that organoids derived from normal colorectal tissue recapitulate the cellular composition and differentiation trajectory of colorectal crypts.
Zhijun Yu   +12 more
wiley   +1 more source

Novel therapeutic strategy targeting STMN1 using chlorambucil‐conjugated pyrrole–imidazole polyamide in small cell lung cancer

open access: yesInternational Journal of Cancer, EarlyView.
What's New? Small cell lung cancer (SCLC) is aggressive and difficult to treat but exhibits high levels of stathmin 1 (STMN1), a candidate therapeutic target. In this study, the authors synthesized a chlorambucil (Chb)‐conjugated pyrrole–imidazole polyamide (PIP) compound targeting the STMN1 promoter and DNA sequences and evaluated its efficacy in ...
Ryohei Yoshikawa   +23 more
wiley   +1 more source

FIGO committee opinion: Environmental drivers of gynecologic and reproductive health

open access: yesInternational Journal of Gynecology &Obstetrics, EarlyView.
Abstract This FIGO committee opinion paper addresses the growing body of evidence linking environmental exposures to common gynecologic and reproductive conditions across the life course. From adolescence through menopause, women are exposed to a wide range of environmental toxicants, including endocrine‐disrupting chemicals, air pollutants, heavy ...
Nathaniel DeNicola   +9 more
wiley   +1 more source

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