Results 71 to 80 of about 379,827 (391)
Protein phosphatases in the regulation of mitosis
Journal of Cell Biology, 2018 Nilsson reviews the essential role of phosphoprotein phosphatases in the regulation of controlled dephosphorylation during cell division.
J. Nilsson
semanticscholar +1 more source
Identifying prognostic targets in metastatic prostate cancer beyond AR
FEBS Open Bio, EarlyView.Genome‐wide functional screens combined with a large gene expression database and clinical outcomes can identify new therapeutic vulnerabilities in prostate cancer. Eight potentially druggable targets demonstrated strong dependency in cell lines, were associated with worse prognosis clinically, and showed evidence of protein expression in prostate ...
Emily Feng +13 more
wiley +1 more source
Cell Reports, 2014 Mitosis is a moment of exquisite vulnerability for a metazoan cell. Failure to complete mitosis accurately can lead to aneuploidy and cancer initiation.
Pengbo Wang +8 more
doaj +1 more source
Importance of the CEP215-pericentrin interaction for centrosome maturation during mitosis. [PDF]
PLoS ONE, 2014 At the onset of mitosis, the centrosome undergoes maturation, which is characterized by a drastic expansion of the pericentriolar material (PCM) and a robust increase in microtubule-organizing activity.
Seongjae Kim, Kunsoo Rhee
doaj +1 more source
Matrix: a complex amalgam of structures and functions in tumor microenvironment
FEBS Open Bio, EarlyView.The matrix is a dynamic, intricate three‐dimensional mesh of biomolecules with both structural and functional properties. This review deals with the complexity of this ‘molecular amalgam’ in the tumor microenvironment and highlights its importance in the maintenance and evolution of tumors by describing certain matrix biomolecules, such as ...
Spyros S. Skandalis +3 more
wiley +1 more source
Acta Pediátrica de México, 2014 Cell division by mitosis is essential for the development of organisms and their reproduction; it is also necessary that each new cell is genetically identical to that from which it comes.
Alfredo de Jesús Rodríguez-Gómez +1 more
doaj +3 more sources
Comprehensive identification of SUMO2/3 targets and their dynamics during mitosis. [PDF]
PLoS ONE, 2014 During mitosis large alterations in cellular structures occur rapidly, which to a large extent is regulated by post-translational modification of proteins.
Julie Schou +4 more
doaj +1 more source
A stable mode of bookmarking by TBP recruits RNA polymerase II to mitotic chromosomes. [PDF]
, 2018 Maintenance of transcription programs is challenged during mitosis when chromatin becomes condensed and transcription is silenced. How do the daughter cells re-establish the original transcription program?
An, Luye +5 more
core
The Consequences of Chromosome Segregation Errors in Mitosis and Meiosis
Biology, 2017 Mistakes during cell division frequently generate changes in chromosome content, producing aneuploid or polyploid progeny cells. Polyploid cells may then undergo abnormal division to generate aneuploid cells.
T. Potapova, G. Gorbsky
semanticscholar +1 more source
Advanced Biology, EarlyView.Chromatin, which organizes DNA, changes its structure to adapt to stress like high oxygen levels (hyperoxia), which can damage cells. Researchers developed a technique to observe these changes and found variability in how different parts of chromatin remodel.
Lauren Monroe +4 more
wiley +1 more source