Results 51 to 60 of about 46,698 (168)
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
PLoS ONEIdentifying mitosis is crucial for cancer diagnosis, but accurate detection remains difficult because of class imbalance and complex morphological variations in histopathological images.
Afnan M Alhassan, Nouf I Altmami
doaj +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Cellular tracking and mitosis detection in dense in-vitro cellular data [PDF]
, 2012 Cell migration and cell division are two key processes that are associated with a wide range of biological phenomena including embryogenesis, inflammation, wound healing, tumour development etc.
Thirusittampalam, Ketheesan
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Cell DivisionIntroduction Anti-mitosis has been a key strategy of anti-cancer therapies, targeting at a fundamental property of cancer cells, their non-controllable proliferation due to overactive mitotic divisions. For improved anti-cancer therapies, it is important
Iram Shazia Tyagi +12 more
doaj +1 more source
Regulation of autophagy during mitosis [PDF]
, 2021 Based on observations of mitosis process, it has been implied that autophagy is repressed. Because the integrity of chromosomes and proteins are significant for cell cycle, the repression of autophagy serves as a protection.
Yikang Gong, Gong Yikang
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The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
TBXA2R activates ERMs to drive motility, invasion, and metastatic colonization of TNBC cells
Life Science AllianceTBXA2R signaling activates ERMs through Gαq/11-Gα12/13, Rho GTPases, and SLK/LOK, boosting TNBC cell migration, invasion, and metastatic colonization. Cell migration and invasion are critical for cancer cell metastasis, relying on the ability of cells to
Kévin Leguay +12 more
doaj +1 more source
Recent Research Advances in Mitosis during Mammalian Gametogenesis
Cells, 2019 Mitosis is a highly sophisticated and well-regulated process during the development and differentiation of mammalian gametogenesis. The regulation of mitosis plays an essential role in keeping the formulation in oogenesis and gametogenesis.
Jia-Hao Wang +5 more
doaj +1 more source
RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells
FEBS Open Bio, EarlyView.RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour +2 more
wiley +1 more source