Results 41 to 50 of about 46,698 (168)

Fcp1 phosphatase controls Greatwall kinase to promote PP2A-B55 activation and mitotic progression

eLife, 2015
During cell division, progression through mitosis is driven by a protein phosphorylation wave. This wave namely depends on an activation-inactivation cycle of cyclin B-dependent kinase (Cdk) 1 while activities of major protein phosphatases, like PP1 and ...
Rosa Della Monica, Roberta Visconti, Nando Cervone, Angela Flavia Serpico, Domenico Grieco   +4 more
doaj   +1 more source

Cigarette smoke condensate induces centrosome clustering in normal lung epithelial cells

Cancer Medicine, 2023
Background Unlike normal cells, cancer cells frequently have multiple centrosomes that can cluster to form bipolar mitotic spindles and allow for successful cell division.
Jose Thaiparambil, Chandra S. Amara, Subrata Sen, Nagireddy Putluri, Randa El‐Zein   +4 more
doaj   +1 more source

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

Podocyte Mitosis - A Catastrophe [PDF]

Current Molecular Medicine, 2012
Podocyte loss plays a key role in the progression of glomerular disorders towards glomerulosclerosis and chronic kidney disease. Podocytes form unique cytoplasmic extensions, foot processes, which attach to the outer surface of the glomerular basement membrane and interdigitate with neighboring podocytes to form the slit diaphragm.
LASAGNI, LAURA, LAZZERI, ELENA, Shankland SJ, Anders HJ, ROMAGNANI, PAOLA   +4 more
openaire   +3 more sources

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Mitosis, Focus on Calcium

, 2022
The transformation of a single fertilised egg into an adult human consisting of tens of trillions of highly diverse cell types is a marvel of biology. The expansion is largely achieved by cell duplication through the process of mitosis.
Haynes, Lee P., Helassa, Nordine, Nugues, Charlotte, Haynes, Lee P, Nordine Helassa, Charlotte Nugues, Lee P. Haynes   +6 more
core   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

CLASP promotes microtubule bundling in metaphase spindle independently of Ase1/PRC1 in fission yeast

Biology Open, 2019
Microtubules in the mitotic spindle are organised by microtubule-associated proteins. In the late stage of mitosis, spindle microtubules are robustly organised through bundling by the antiparallel microtubule bundler Ase1/PRC1. In early mitosis, however,
Hirohisa Ebina, Liang Ji, Masamitsu Sato
doaj   +1 more source

A PKD-MFF signaling axis couples mitochondrial fission to mitotic progression

Cell Reports, 2021
Summary: Mitochondria are highly dynamic organelles subjected to fission and fusion events. During mitosis, mitochondrial fission ensures equal distribution of mitochondria to daughter cells. If and how this process can actively drive mitotic progression
Evanthia Pangou, Olga Bielska, Lucile Guerber, Stephane Schmucker, Arantxa Agote-Arán, Taozhi Ye, Yongrong Liao, Marta Puig-Gamez, Erwan Grandgirard, Charlotte Kleiss, Yansheng Liu, Emmanuel Compe, Zhirong Zhang, Ruedi Aebersold, Romeo Ricci, Izabela Sumara   +15 more
doaj   +1 more source

Mitosis

, 2021
Analisis de las fases de la mitosis y uso de inhibidores del husohttps://polimedia.upv.es/visor/?id=c74063d0-bf8a-11eb-a2dc-25bae68df3bfCebolla Cornejo, J. (2021). Mitosis. Universitat Politècnica de València.
Cebolla Cornejo, Jaime
core