Results 41 to 50 of about 312,064 (187)
Cell DivisionIntroduction Anti-mitosis has been a key strategy of anti-cancer therapies, targeting at a fundamental property of cancer cells, their non-controllable proliferation due to overactive mitotic divisions. For improved anti-cancer therapies, it is important
Iram Shazia Tyagi +12 more
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Recent Research Advances in Mitosis during Mammalian Gametogenesis
Cells, 2019 Mitosis is a highly sophisticated and well-regulated process during the development and differentiation of mammalian gametogenesis. The regulation of mitosis plays an essential role in keeping the formulation in oogenesis and gametogenesis.
Jia-Hao Wang +5 more
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Cell cycle regulation of a Xenopus Wee1-like kinase [PDF]
, 1995 Using a polymerase chain reaction-based strategy, we have isolated a gene encoding a Wee1-like kinase from Xenopus eggs. The recombinant Xenopus Wee1 protein efficiently phosphorylates Cdc2 exclusively on Tyr- 15 in a cyclin-dependent manner.
Coleman, Thomas R. +2 more
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PLoS ONEIdentifying mitosis is crucial for cancer diagnosis, but accurate detection remains difficult because of class imbalance and complex morphological variations in histopathological images.
Afnan M Alhassan, Nouf I Altmami
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TBXA2R activates ERMs to drive motility, invasion, and metastatic colonization of TNBC cells
Life Science AllianceTBXA2R signaling activates ERMs through Gαq/11-Gα12/13, Rho GTPases, and SLK/LOK, boosting TNBC cell migration, invasion, and metastatic colonization. Cell migration and invasion are critical for cancer cell metastasis, relying on the ability of cells to
Kévin Leguay +12 more
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Importin-beta and CRM1 control a RANBP2 spatiotemporal switch essential for mitotic kinetochore function [PDF]
, 2017 Protein conjugation with small ubiquitin-related modifier (SUMO) is a post-translational modification that modulates protein interactions and localisation.
Damizia, Michela +7 more
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Cell Reports, 2014 Mitosis is a moment of exquisite vulnerability for a metazoan cell. Failure to complete mitosis accurately can lead to aneuploidy and cancer initiation.
Pengbo Wang +8 more
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The distribution of cytoplasmic microtubules throughout the cell cycle of the centric diatom Stephanopyxis turris: their role in nuclear migration and positioning the mitotic spindle during cytokinesis. [PDF]
, 1986 The cell cycle of the marine centric diatom Stephanopyxis turris consists of a series of spatially and temporally well-ordered events. We have used immunofluorescence microscopy to examine the role of cytoplasmic microtubules in these events.
Cande, WZ, McDonald, KL, Wordeman, L
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Domain-adversarial neural networks to address the appearance variability of histopathology images
, 2017 Preparing and scanning histopathology slides consists of several steps, each with a multitude of parameters. The parameters can vary between pathology labs and within the same lab over time, resulting in significant variability of the tissue appearance ...
Eppenhof, Koen A. J. +4 more
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The dynamics of replication licensing in live Caenorhabditis elegans embryos [PDF]
, 2012 Accurate DNA replication requires proper regulation of replication licensing, which entails loading MCM-2-7 onto replication origins. In this paper, we provide the first comprehensive view of replication licensing in vivo, using video microscopy of ...
Anton Gartner +56 more
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