Results 21 to 30 of about 166,111 (267)
Developmental Cell, 2013 Reporting in Developmental Cell, Schlaitz et al. (2013) show that endoplasmic reticulum (ER) membrane exclusion from the mitotic spindle is an active process requiring REEP membrane proteins. REEP protein depletion results in ER membrane retention on the spindle and chromosomes, leading to defects in chromosome segregation and nuclear envelope assembly.
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eLife, 2016 Mitosis occurs efficiently, but when it is disturbed or delayed, p53-dependent cell death or senescence is often triggered after mitotic exit. To characterize this process, we conducted CRISPR-mediated loss-of-function screens using a cell-based assay in
Chii Shyang Fong +7 more
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IEEE Access, 2020 Detection of mitotic tumor cells per tissue area is one of the critical markers of breast cancer prognosis. The aim of this paper is to develop a method for the automatic detection of mitotic figures from breast cancer histological slides using a ...
Meriem Sebai +2 more
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The Biochemistry of Mitosis [PDF]
Cold Spring Harbor Perspectives in Biology, 2015 In this article, we will discuss the biochemistry of mitosis in eukaryotic cells. We will focus on conserved principles that, importantly, are adapted to the biology of the organism. It is vital to bear in mind that the structural requirements for division in a rapidly dividing syncytial Drosophila embryo, for example, are markedly different from those
Samuel, Wieser, Jonathon, Pines
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IEEE AccessAt present, mitosis detection in breast histopathology images is a critical issue for breast cancer grading. Due to the breast tissue having a complex structure, and mitosis and non-mitosis cells being similar to each other, traditional methods for ...
Sarah Ayashm +3 more
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Mitosis sans Mitosis: The Mitotic Oscillator in Differentiation [PDF]
Developmental Cell, 2017 Differentiation and proliferation are usually considered to be antagonistic partners in development. However, in a recent issue of Science, Al Jord et al. (2017) show that key regulators of the mitotic cycle are redeployed in differentiating multiciliated cells to promote ciliogenesis without mitotic progression.
Miranda, Stratton, Tim, Stearns
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Fcp1 phosphatase controls Greatwall kinase to promote PP2A-B55 activation and mitotic progression
eLife, 2015 During cell division, progression through mitosis is driven by a protein phosphorylation wave. This wave namely depends on an activation-inactivation cycle of cyclin B-dependent kinase (Cdk) 1 while activities of major protein phosphatases, like PP1 and ...
Rosa Della Monica +4 more
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Cigarette smoke condensate induces centrosome clustering in normal lung epithelial cells
Cancer Medicine, 2023 Background Unlike normal cells, cancer cells frequently have multiple centrosomes that can cluster to form bipolar mitotic spindles and allow for successful cell division.
Jose Thaiparambil +4 more
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Stressing Mitosis to Death [PDF]
Frontiers in Oncology, 2014 The final stage of cell division (mitosis), involves the compaction of the duplicated genome into chromatid pairs. Each pair is captured by microtubules emanating from opposite spindle poles, aligned at the metaphase plate, and then faithfully segregated to form two identical daughter cells. Chromatids that are not correctly attached to the spindle are
Andrew eBurgess +3 more
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FEBS Letters, EarlyView.This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
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