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Mitotane Concentrations Influence Outcome in Patients with Advanced Adrenocortical Carcinoma [PDF]
Cancers, 2020 Mitotane is the main option of treatment for advanced adrenocortical carcinoma (ACC). However, limited evidence is available regarding the impact of plasma mitotane levels on patient outcome. To address this question, we retrospectively analyzed patients
Marco Russo +2 more
exaly +4 more sources
Metabolic and Endocrine Toxicities of Mitotane: A Systematic Review [PDF]
Cancers, 2021 BACKGROUND Mitotane is currently used for the treatment of unresectable adrenocortical cancer and as adjuvant therapy in patients with a high risk of recurrence.
Rosa Lauretta +2 more
exaly +4 more sources
Lipoprotein-Free Mitotane Exerts High Cytotoxic Activity in Adrenocortical Carcinoma
Journal of Clinical Endocrinology and Metabolism, 2015 International audienceContext: Mitotane (o,p’-DDD), the only approved drug for advanced adrenocortical carcinoma (ACC), is a lipophilic agent that accumulates into circulating lipoprotein fractions and high lipid-containing tissues. Objective: The aim of
Sophie Broutin +2 more
exaly +2 more sources
Development of microemulsion of mitotane for improvement of oral bioavailability
Drug Development and Industrial Pharmacy, 2010 International audienceBACKGROUND: Mitotane (o,p'-DDD) is considered to be the drug of choice in the treatment of nonresectable and metastasized adrenocortical carcinoma.
Stéphane Gibaud, Alain Astier
exaly +2 more sources
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Inhibitory effects of mitotane on viability and secretory activity in mouse gonadotroph cell lines
Reproductive Toxicology, 2014 Mitotane represents the mainstay medical treatment for metastatic, inoperable or recurrent adrenocortical carcinoma. Besides the well-known adverse events, mitotane therapy is associated also with endocrinological effects, including sexual and ...
Maria Chiara Zatelli +2 more
exaly +2 more sources