Stimulation of Erythrocyte Cell Membrane Scrambling by Mitotane
Cellular Physiology and Biochemistry, 2014 Background: Mitotane (1,1-dichloro-2-[o-chlorophenyl]-2-[p-chlorophenyl]ethane), a cytostatic drug used for the treatment of adrenocortical carcinomas, is effective by triggering tumor cell apoptosis. In analogy to apoptosis of nucleated cells, eryptosis
Janin Jacobi +7 more
doaj +1 more source
GPER agonist G-1 decreases adrenocortical carcinoma (ACC) cell growth in vitro and in vivo [PDF]
, 2015 We have previously demonstrated that estrogen receptor (ER) alpha (ESR1) increases proliferation of adrenocortical carcinoma (ACC) through both an estrogen-dependent and -independent (induced by IGF-II/IGF1R pathways) manner.
Amendola, Donatella +16 more
core +2 more sources
Aspectos clínicos e moleculares de tumor adrenocortical metacrônico pediátrico [PDF]
, 2011 The occurrence of metachronous adrenocortical carcinoma has rarely been described. We report a case of a child with virilizing adrenocortical metachronous tumors that, despite several metastases, presented long-term survival (15 years).
ALENCAR, Guilherme Asmar +8 more
core +2 more sources
Adjuvant therapy in adrenocortical carcinoma: prognostic factors and treatment options
Endocrine Oncology, 2023 Adrenocortical carcinoma (ACC) is a rare cancer with high recurrence rates and heterogeneous clinical behavior. The role of adjuvant therapy remains unclear because of the challenges in collecting high-quality data for a rare cancer.
Ruaa Al-Ward +2 more
doaj +1 more source
Synthesis of β‐ 3 H‐mitotane for use in a rapid assay for mitotane metabolism [PDF]
, 1995 A 3 H + ‐release method has been developed for the assay of β‐hydroxylation of the adrenolytic drug mitotane. β‐ 3 H‐mitotane was synthesized by the reduction of 1‐(2‐chlorophenyl)‐1‐(4‐chlorophenyl)‐2,2,2‐trichloroethane by an aluminium‐Hg 2 Cl 2 ...
Counsell, Raymond E. +5 more
core +1 more source
Monitoring the response of canine hyperadrenocorticism to trilostane treatment by assessment of acute phase protein concentrations [PDF]
, 2010 <b>Background</b>: Acute phase proteins (APPS) include haptoglobin (Hp), C-reactive protein (CRP) and serum amyloid A (SAA). Increased Hp concentrations may be induced by endogenous or exogenous glucocorticoids in dogs. <b>Objectives&
Angles +36 more
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Diabetes mellitus secondary to Cushing's disease [PDF]
, 2018 Associated with important comorbidities that significantly reduce patients’ overall wellbeing and life expectancy, Cushing’s disease (CD) is the most common cause of endogenous hypercortisolism.
Barbot, Mattia +2 more
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The impact of mitotane therapy on serum-free proteins in patients with adrenocortical carcinoma
Endocrine ConnectionsIntroduction: Adrenocortical carcinoma (ACC) is a rare malignancy of the adrenal cortex. Whilst surgery is the preferred treatment, adjunctive therapy with mitotane may be offered post-surgically to minimise the risk of recurrence or, in the absence of ...
Magdalena Lech +12 more
doaj +1 more source
Neurological adverse events of mitotane in adrenocortical carcinoma: results of a pilot study
Frontiers in Oncology, 2023 IntroductionMitotane, the only drug approved by the Food and Drug Administration (FDA) for the treatment of adrenocortical carcinoma, is associated with several side effects including neurotoxicity. The aim of our study is to investigate the relationship
Marilda Mormando +11 more
doaj +1 more source
Outcome after resection of Adrenocortical Carcinoma liver metastases: a retrospective study [PDF]
, 2017 Background: Metastatic Adrenocortical Carcinoma (ACC) is a rare malignancy with a poor 5-year-survival rate (
Christine Spitzweg +11 more
core +1 more source