Results 51 to 60 of about 5,485 (197)

Aspectos clínicos e moleculares de tumor adrenocortical metacrônico pediátrico [PDF]

, 2011
The occurrence of metachronous adrenocortical carcinoma has rarely been described. We report a case of a child with virilizing adrenocortical metachronous tumors that, despite several metastases, presented long-term survival (15 years).
ALENCAR, Guilherme Asmar, ALMEIDA, Madson Queiroz, BRITO, Luciana Pinto, DOMENICE, Sorahia, FRAGOSO, Maria Candida Barrison Villares, LATRONICO, Ana Claudia, LERARIO, Antonio Marcondes, LIMA, Lorena de Oliveira, MENDONCA, Berenice Bilharinho   +8 more
core   +2 more sources

Efficacy and Tolerability of Metyrapone in Mild Autonomous Cortisol Secretion: Real‐World Findings From Clinical Practice

Clinical Endocrinology, Volume 104, Issue 3, Page 215-221, March 2026.
ABSTRACT Objective Mild autonomous cortisol secretion (MACS) is associated with increased cardiometabolic risk factors including hypertension, type 2 diabetes and dyslipidaemia. By using evening doses of metyrapone, a short‐acting 11‐β hydroxylase inhibitor, it has been shown that it is possible to reset the abnormal circadian cortisol rhythm in MACS ...
Simon Berry, Ahmed Iqbal, John Newell‐Price, Miguel Debono   +3 more
wiley   +1 more source

Current Treatment Patterns and Outcomes of Sex Cord Stromal Tumor Patients in Japan

International Journal of Urology, Volume 33, Issue 3, March 2026.
ABSTRACT Objectives Sex cord‐stromal tumors (SCSTs) constitute approximately 5% of testicular malignancies. This investigation aimed to elucidate contemporary therapeutic approaches and clinical outcomes for patients with testicular SCSTs in Japan. Methods Participating institutions included Japan Clinical Oncology Group facilities, affiliated centers,
Takashige Abe, Kosuke Miyai, Toyonori Tsuzuki, Sachiyo Murai, Katsuyoshi Hashine, Shinichi Yamashita, Takashi Kawahara, Naotaka Nishiyama, Hiroshi Kitamura, Hiroshi Kikuchi, Kazutaka Saito, Hatsuki Hibi, Haruka Miyata, Ryuji Matsumoto, Takahiro Osawa, Hiroyuki Nishiyama, Nobuo Shinohara   +16 more
wiley   +1 more source

Pharmacogenomic analysis in adrenocortical carcinoma reveals genetic features associated with mitotane sensitivity and potential therapeutics

Frontiers in Endocrinology
BackgroundAdrenocortical carcinoma (ACC) is an aggressive endocrine malignancy with limited therapeutic options. Treating advanced ACC with mitotane, the cornerstone therapy, remains challenging, thus underscoring the significance to predict mitotane ...
Jie Zhang, Luming Wu, Tingwei Su, Haoyu Liu, Lei Jiang, Yiran Jiang, Zhiyuan Wu, Lu Chen, Haorong Li, Jie Zheng, Yingkai Sun, Hangya Peng, Rulai Han, Guang Ning, Lei Ye, Weiqing Wang   +15 more
doaj   +1 more source

Effects of o,p’-DDE, a Mitotane Metabolite, in an Adrenocortical Carcinoma Cell Line

Pharmaceuticals, 2022
In South Brazil, the incidence of pediatric adrenocortical carcinoma (ACC) is higher than in other regions and countries worldwide. The ACC treatment includes therapy with mitotane, the only adrenolytic drug approved by the FDA.
Camila Bach, Claudia Rita Corso, Alan de Almeida Veiga, Mariana Martins Paraizo, Lauro Mera de Souza   +4 more
doaj   +1 more source

Elastographic Evaluation of the Adrenal Glands of Dogs With Hypercortisolism

Veterinary Radiology &Ultrasound, Volume 67, Issue 2, March 2026.
ABSTRACT Elastography is a promising technique for assessing tissue stiffness in the adrenal glands of dogs with hypercortisolism (HC). This study compared 30 dogs, 15 of which were healthy (control group) and 15 diagnosed with HC, confirmed by low‐dose dexamethasone suppression test (n = 11) or ACTH stimulation test (n = 4) without prior treatment ...
Fernanda de Paula Sesti, Gabriel Marchiori Gonzaga, Bruno Alberigi   +2 more
wiley   +1 more source

The tyrosine kinase inhibitor nilotinib is more efficient than mitotane in decreasing cell viability in spheroids prepared from adrenocortical carcinoma cells

Cancer Cell International, 2018
Background New drugs for adrenocortical carcinoma (ACC) are needed because most patients undergo rapid disease progression despite surgery and adjuvant therapy with mitotane.
Elaine Silveira, Isadora Pontes Cavalcante, Jean Lucas Kremer, Pedro Omori Ribeiro de Mendonça, Claudimara Ferini Pacicco Lotfi   +4 more
doaj   +1 more source

Durable response to pembrolizumab in microsatellite instability‐high advanced adrenocortical carcinoma

IJU Case Reports, 2023
Introduction Advanced adrenocortical carcinoma has a poor prognosis and is treated with chemotherapy that includes mitotane with etoposide, doxorubicin, and cisplatin as first‐line therapy.
Masaya Senda, Kohei Hashimoto, Tetsuya Shindo, Ko Kobayashi, Toshiaki Tanaka, Naoya Masumori   +5 more
doaj   +1 more source

Effective treatment with mitotane for a canine case of Ectopic Cushing's syndrome-related pheochromocytoma.

Open Veterinary Journal, 2022
In humans, ectopic Cushing's syndrome (ECS) is characterized by hypercortisolemia, which is caused by small lung carcinoma, bronchial carcinoids, and pheochromocytoma.
Konatsu Miura, Hiroshi Sunahara, Yusuke Sakai   +2 more
doaj   +1 more source

Cushing’s disease [PDF]

, 2012
Cushing’s disease, or pituitary ACTH dependent Cushing’s syndrome, is a rare disease responsible for increased morbidity and mortality. Signs and symptoms of hypercortisolism are usually non specific: obesity, signs of protein wasting, increased blood ...
Bernard Conte-Devolx, Frederic Castinetti, Isabelle Morange, Thierry Brue   +3 more
core   +1 more source