Results 61 to 70 of about 5,485 (197)
Safe long-term therapy of Cushing’s syndrome over 37 years with mitotane
Frontiers in EndocrinologyWhile suggested, surgery is not always possible as a first-line treatment of Cushing’s Disease (CD). In such cases, patients require medical therapy in order to prevent complications resulting from hypercortisolism.
Jonas Seibold +3 more
doaj +1 more source
Medicine Science, 2015 Adrenocortical carcinoma is a rare endocrine malignancy. Patients present with hormone excess or a local mass effect. The tumor is agressive and characterized by a high risk of recurrence even after complete resection. Recurrence rate (particularly local
Pinar Sisman, Canan Ersoy
doaj +1 more source
Clinical Medicine Insights: Oncology, 2021 Adrenocortical carcinoma (ACC) is a rare malignancy with a poor prognosis. Treatment options for ACC are limited, with resection the main intervention. Most cases present in late metastatic cases, and data regarding effective therapies is limited.
Walid Alam +3 more
doaj +1 more source
Corticotropinoma as a Component of Carney Complex. [PDF]
, 2017 Known germline gene abnormalities cause one-fifth of the pituitary adenomas in children and adolescents, but, in contrast with other pituitary tumor types, the genetic causes of corticotropinomas are largely unknown.
Chittiboina, Prashant +11 more
core +2 more sources
The Concise Guide to PHARMACOLOGY 2025/26: Enzymes
British Journal of Pharmacology, Volume 182, Issue S1, Page S307-S403, December 2025.The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander +31 more
wiley +1 more source
Clinical Case Reports, Volume 13, Issue 10, October 2025.Sequential bronchoscopic management of left main bronchus endobronchial metastasis. (A–B) Obstructive lesion visualized. (C) Post‐debulking lumen restored. (D) A 10×30 mm fully covered self‐expanding metal stent placed to maintain airway patency, resulting in improved ventilation and symptom relief.
Sushrut Ingawale +4 more
wiley +1 more source
Powder Self-Emulsifying Drug Delivery System for Mitotane: In Vitro and In Vivo Evaluation
PharmaceuticsDrug Delivery Systems (DDSs) of known drugs are prominent candidates for new and more effective treatments of various diseases, as they may increase drug solubility, dissolution velocity, and bioavailability.
Mohamed Skiba +6 more
doaj +1 more source
Evaluation of 9-cis retinoic acid and mitotane as antitumoral agents in an adrenocortical xenograft model [PDF]
, 2015 The available drug treatment options for adrenocortical carcinoma (ACC) are limited. In our previous studies, the in vitro activity of 9-cis retinoic acid (9-cisRA) on adrenocortical NCI-H295R cells was shown along with its antitumoral effects in a small
Baghy, Kornélia +12 more
core
Complications of Cushing's syndrome: state of the art [PDF]
, 2016 Cushing's syndrome is a serious endocrine disease caused by chronic, autonomous, and excessive secretion of cortisol. The syndrome is associated with increased mortality and impaired quality of life because of the occurrence of comorbidities.
Biller, Beverly M. K +5 more
core +1 more source
Feminizing adrenocortical carcinoma with distant metastases: can surgery be considered? [PDF]
, 2014 Functioning adrenocortical carcinomas are rare diseases with dismal prognosis. A 41-yearold man presenting with gynecomastia had a giant feminizing adrenocortical carcinoma at stage IV.
Fancellu, Alessandro +2 more
core +3 more sources