Results 61 to 70 of about 3,958 (169)

Complete Radiological Response of Recurrent Metastatic Adrenocortical Carcinoma to Pembrolizumab and Mitotane

Clinical Medicine Insights: Oncology, 2021
Adrenocortical carcinoma (ACC) is a rare malignancy with a poor prognosis. Treatment options for ACC are limited, with resection the main intervention. Most cases present in late metastatic cases, and data regarding effective therapies is limited.
Walid Alam, Youssef Bouferraa, Yolla Haibe, Ali Shamseddine   +3 more
doaj   +1 more source

Elastographic Evaluation of the Adrenal Glands of Dogs With Hypercortisolism

Veterinary Radiology &Ultrasound, Volume 67, Issue 2, March 2026.
ABSTRACT Elastography is a promising technique for assessing tissue stiffness in the adrenal glands of dogs with hypercortisolism (HC). This study compared 30 dogs, 15 of which were healthy (control group) and 15 diagnosed with HC, confirmed by low‐dose dexamethasone suppression test (n = 11) or ACTH stimulation test (n = 4) without prior treatment ...
Fernanda de Paula Sesti, Gabriel Marchiori Gonzaga, Bruno Alberigi   +2 more
wiley   +1 more source

Mitotane-Induced Hyperlipidemia: A Retrospective Cohort Study [PDF]

, 2020
Limited data are available about mitotane-nduced hyperlipidemia. We retrospectively analyzed lipid data in 38 patients with adrenocortical carcinoma (ACC) who received mitotane therapy with emphasis on HDL cholesterol (HDL-c) and clinical predictors of ...
Hadil Bazerbashi, Rena Vassilopoulou-Sellin, Camilo Jimenez, Mouhammed Amir Habra, Hassan Shawa, Ferhat Deniz, Mike Hernandez   +6 more
core  

Safe long-term therapy of Cushing’s syndrome over 37 years with mitotane

Frontiers in Endocrinology
While suggested, surgery is not always possible as a first-line treatment of Cushing’s Disease (CD). In such cases, patients require medical therapy in order to prevent complications resulting from hypercortisolism.
Jonas Seibold, Mario Hönemann, Anke Tönjes, Benjamin Sandner   +3 more
doaj   +1 more source

Powder Self-Emulsifying Drug Delivery System for Mitotane: In Vitro and In Vivo Evaluation

Pharmaceutics
Drug Delivery Systems (DDSs) of known drugs are prominent candidates for new and more effective treatments of various diseases, as they may increase drug solubility, dissolution velocity, and bioavailability.
Mohamed Skiba, Valentin Lefébure, Frederic Bounoure, Nicolas Milon, Michael Thomas, Herve Lefebvre, Lahiani-Skiba Malika   +6 more
doaj   +1 more source

Alternating Therapy With Osilodrostat and Etomidate in Severe Ectopic Cushing’s Syndrome Complicated by Silent Bowel Perforation

Case Reports in Endocrinology, Volume 2026, Issue 1, 2026.
Ectopic adrenocorticotropic hormone (ACTH)‐dependent Cushing’s syndrome (CS), ectopic ACTH secretion (EAS) is a rare condition caused by ACTH‐secreting neuroendocrine tumors (NETs), such as bronchial carcinoids. We report a 65‐year‐old woman with severe EAS complicated by bowel perforation.
Hery Mejia, Carmen Villabona, Renato Savian, Susana Barreiro Sacco, Alejandra Razzeto, Tanira Ferreira, Virginia Kondas, Sixto Arias, Elio Donna, Violet Lagari, Kalyani Sen   +10 more
wiley   +1 more source

The Concise Guide to PHARMACOLOGY 2025/26: Enzymes

British Journal of Pharmacology, Volume 182, Issue S1, Page S307-S403, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Doriano Fabbro, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Stephanie Annett, Detlev Boison, Kathryn Elisa Burns, Carmen Dessauer, Jürg Gertsch, Nuala Ann Helsby, Angelo A. Izzo, Rennolds Ostrom, Ester Pagano, Andreas Papapetropoulos, Nigel J. Pyne, Susan Pyne, Tracy Robson, Roland Seifert, Johannes‐Peter Stasch, Csaba Szabo, Mario van der Stelt, Albert van der Vliet, Val Watts, Szu Shen Wong   +31 more
wiley   +1 more source

A retrospective cohort study of 122 dogs treated for hypercortisolism: low-dose dexamethasone suppression test sensitivity and comparative outcomes in response to mitotane or trilostane [PDF]

Arquivo Brasileiro de Medicina Veterinária e Zootecnia
Spontaneous hypercortisolism (HC), a prevalent endocrinopathy among elderly dogs, is mainly confirmed by the low dexamethasone dose suppression test (LDDST).
M.M. Marçal, S.F.M. Martins, C.R. Barbieri, T.B. Nogueira, Á.G. Pöppl   +4 more
doaj   +1 more source

Molecular Targets of Mitotane in Adrenocortical Carinoma

, 2015
Le mitotane, ou o,p’DDD, médicament historique dérivé d’un insecticide, reste le traitement de référence du corticosurrénalome (CS), tumeur rare et de mauvais pronostic. Le mitotane exerce un effet anti-sécrétoire associé à un effet anti-tumoral dont les
Hescot, Ségolène
core  

Role of Palliative Bronchial Stenting in Endobronchial Metastasis: An Atypical Case of Metastatic Adrenocortical Carcinoma in a Young Patient

Clinical Case Reports, Volume 13, Issue 10, October 2025.
Sequential bronchoscopic management of left main bronchus endobronchial metastasis. (A–B) Obstructive lesion visualized. (C) Post‐debulking lumen restored. (D) A 10×30 mm fully covered self‐expanding metal stent placed to maintain airway patency, resulting in improved ventilation and symptom relief.
Sushrut Ingawale, Nuthan Bhat, Rahul Kothari, Shivaji Karki, Abhiroop Verma   +4 more
wiley   +1 more source