Results 81 to 90 of about 5,485 (197)

IGF-I influences everolimus activity in medullary thyroid carcinoma [PDF]

, 2015
Context: Medullary thyroid carcinoma (MTC) is a rare tumor originating from thyroid parafollicular C cells. It has been previously demonstrated that insulin-like growth factor I (IGF-I) protects MTC from the effects of antiproliferative drugs. Everolimus,
degli Uberti, Ettore C., Di Pasquale, Carmelina, Gagliano, Teresa, GENTILIN, ERICA, MERANTE BOSCHIN, ISABELLA, Pelizzo, Mariarosa, Rossi, Martina, Rossi, Roberta, Tagliati, Federico, Zatelli, Maria Chiara   +9 more
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Novel Polymyxin Combination With Antineoplastic Mitotane Improved the Bacterial Killing Against Polymyxin-Resistant Multidrug-Resistant Gram-Negative Pathogens

Frontiers in Microbiology, 2018
Due to limited new antibiotics, polymyxins are increasingly used to treat multidrug-resistant (MDR) Gram-negative bacteria, in particular carbapenem-resistant Acinetobacter baumannii, Pseudomonas aeruginosa, and Klebsiella pneumoniae.
Thien B. Tran, Thien B. Tran, Jiping Wang, Jiping Wang, Yohei Doi, Tony Velkov, Tony Velkov, Phillip J. Bergen, Phillip J. Bergen, Jian Li   +9 more
doaj   +1 more source

The PI3K/Akt Pathway in Tumors of Endocrine Tissues [PDF]

, 2016
The phosphatidylinositol 3-kinase (PI3K)/Akt pathway is a key driver in carcinogenesis. Defects in this pathway in human cancer syndromes such as Cowden’s disease and Multiple Endocrine Neoplasia result in tumors of endocrine tissues, highlighting its ...
Hague, Angela, Robbins, Helen Louise
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Evaluation of cortisol precursors for the diagnosis of pituitary-dependent hypercortisolism in dogs [PDF]

, 2008
The serum concentrations of cortisol, 17alpha-hydroxypregnenolone, 17alpha-hydroxyprogesterone, 21-deoxycortisol and 11-deoxycortisol were measured in 19 healthy dogs, 15 dogs with pituitary-dependent hypercortisolism (pdh) and eight dogs with other ...
Boretti, Felicitas S, Maser-Gluth, C, Reusch, Claudia E, Sieber-Ruckstuhl, Nadja S, Wenger, M   +4 more
core   +1 more source

novel insights into the genetics and pathophysiology of adrenocortical tumors [PDF]

, 2015
International audienceAdrenocortical tumors (ACTs) are typically unilateral and can be classified as benign adrenocortical adenomas (ACAs) or malignant adrenocortical cancers (ACCs).
Drougat, Ludivine, Lefèvre, Lucile, Omeiri, Hanin, Ragazzon, Bruno   +3 more
core   +7 more sources

Advanced adrenocortical carcinoma successfully treated with gemcitabine plus capecitabine as second‐line chemotherapy

IJU Case Reports, 2020
Introduction Adrenocortical carcinoma is a rare malignant tumor with an unfavorable prognosis in the advanced stage for which second‐/third‐line chemotherapy is not well established.
Akinaru Yamamoto, Yasutomo Nakai, Toshiki Oka, Tomohiro Kanaki, Yoshiyuki Yamamoto, Akira Nagahara, Masashi Nakayama, Ken‐ichi Kakimoto, Kazuo Nishimura   +8 more
doaj   +1 more source

Diagnosis and treatment of canine hypoadrenocorticism [PDF]

, 2018
Canine hypoadrenocorticism (Addison’s disease), the ‘great pretender’ of internal medicine, is a disease that should be frequently considered as a differential diagnosis of several clinical presentations, albeit it is less commonly the actual cause of ...
Gunn, Eilidh, Ramsey, Ian, Spence, Susanna   +2 more
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Clonal Composition of Human Adrenocortical Neoplasms [PDF]

, 1994
The mechanisms of tumorigenesis of adrenocortical neoplasms are still not understood. Tumor formation may be the result of spontaneous transformation of adrenocortical cells by somatic mutations.
Abdelhamid, S., Allolio, B., Beuschlein, Felix, Chrousos, G. P., Jaursch-Hancke, C., Karl, M., Reincke, Martin, Travis, W.   +7 more
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Pharmacokinetic variability of mitotane in pediatric adrenocortical carcinoma and the role of CYP2B6 genotypes: a pediatric case series

EJC Paediatric Oncology
Despite therapeutic drug monitoring of mitotane, achieving target plasma concentrations remains challenging. Commonly reported enzymes involved in mitotane metabolism are cytochrome P450 (CYP)3A4 and 2B6, with CYP2B6 being highly polymorphic.
Ivy A.E. Ankone, Tirsa de Kluis, Lidwien M. Hanff, Antoinette Jaspers-Bakker, Ronald R. de Krijger, Jesse J. Swen, Kathalijne A. Oudhoff, Marieke J.M. Meijs, Max M. van Noesel, Alwin D.R. Huitema, Meta H.M. Diekstra   +10 more
doaj   +1 more source

Keganasan Kelenjar Adrenal [PDF]

, 2009
Kelenjar adrenal merupakan organ bilateral retroperitoneal pada kutub atas masing-masing ginjal dengan berat empat gram. Kelenjar ini terdiri dari dua bagian, yaitu korteks dan medula, dalam satu kesatuan jaringan berkapsul dan berfungsi menghasilkan ...
Kastomo, D. R. (Dukut)
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