Results 71 to 80 of about 5,485 (197)

The Role of Immune Checkpoint Inhibitors in Adrenocortical Carcinoma: Enhancing Post‐Surgical Outcomes and Overcoming Relapse

Medicine Advances, Volume 3, Issue 3, Page 205-208, September 2025.
Adrenocortical carcinoma (ACC) is a rare and aggressive cancer that's usually detected at an advanced stage and has a high recurrence rate despite surgical resection, making treatment challenging. Although mitotane is still the only approved treatment, its poor effectiveness has raised interest in immunotherapy with immune checkpoint inhibitors (ICIs ...
Jawairya Muhammad Hussain, Saim Mahmood Khan, Haiqa Sultan, Diya Rathi, Eyob Mekonnen Woldeyohannes, Zemichael Getu Alemayehu   +5 more
wiley   +1 more source

Clinical characteristics, treatment, and outcomes of hypoadrenocorticism in dogs

Journal of Small Animal Practice, Volume 66, Issue 9, Page 627-635, September 2025.
Objectives To determine the long‐term survival of dogs with hypoadrenocorticism during the period that desoxycorticosterone pivalate has become widely used. Secondary goals were to compare age at diagnosis, median survival times, and age at death for dogs with hyponatraemic and/or hyperkalaemic hypoadrenocorticism and eunatraemic eukalaemic ...
T. N. Sherrod, E. Lashnits, K. F. Lunn
wiley   +1 more source

Mitotane-Induced Hyperlipidemia: A Retrospective Cohort Study

International Journal of Endocrinology, 2013
Limited data are available about mitotane-nduced hyperlipidemia. We retrospectively analyzed lipid data in 38 patients with adrenocortical carcinoma (ACC) who received mitotane therapy with emphasis on HDL cholesterol (HDL-c) and clinical predictors of ...
Hassan Shawa, Ferhat Deniz, Hadil Bazerbashi, Mike Hernandez, Rena Vassilopoulou-Sellin, Camilo Jimenez, Mouhammed Amir Habra   +6 more
doaj   +1 more source

A retrospective cohort study of 122 dogs treated for hypercortisolism: low-dose dexamethasone suppression test sensitivity and comparative outcomes in response to mitotane or trilostane [PDF]

Arquivo Brasileiro de Medicina Veterinária e Zootecnia
Spontaneous hypercortisolism (HC), a prevalent endocrinopathy among elderly dogs, is mainly confirmed by the low dexamethasone dose suppression test (LDDST).
M.M. Marçal, S.F.M. Martins, C.R. Barbieri, T.B. Nogueira, Á.G. Pöppl   +4 more
doaj   +1 more source

Role of the mTOR pathway in normal and tumoral adrenal cells [PDF]

, 2010
The mammalian target of rapamycin (mTOR) is a kinase of the phosphoinositide 3-kinase (PI3Ks)/protein kinase B (PKB or AKT) signaling pathway, which is one of the most important intracellular mediators of the activity of growth factors receptors ...
Hofland, L.J. (Leo), Koetsveld, P.M. (Peter) van, Martino, M.C. (Maria Cristina) de, Pivonello, R. (Rosario)   +3 more
core   +1 more source

Bilateral Adrenal Ablation for the Treatment of Ectopic ACTH Syndrome With Severe Hypokalemia: A Case Report and a Literature Review

Clinical Case Reports, Volume 13, Issue 8, August 2025.
ABSTRACT Ectopic ACTH secretion‐related Cushing's syndrome may manifest as a rapid onset of hypercortisolism, elevated urinary free cortisol (UFC) and blood ACTH concentrations, and hypokalemia. However, for patients whose primary lesions are difficult to remove, bilateral adrenalectomy is the recommended treatment method according to guidelines. Here,
Fang Sun, Yuyu Sun, Hongbo He, Zhigang Zhao, Hexuan Zhang, Nan Jiang, Zhiming Zhu   +6 more
wiley   +1 more source

Emerging drugs for Cushing's disease [PDF]

, 2015
INTRODUCTION: Considering the effects of uncontrolled hypercortisolism on morbidity and mortality, there is a clear need for effective medical therapy for patients with Cushing's disease (CD).
Grossman, AB, Guelho, DL
core   +1 more source

Mitochondria‐Associated Endoplasmic Reticulum Membranes in Human Health and Diseases

MedComm, Volume 6, Issue 7, July 2025.
MAM dysfunction is considered as an initiator or contributor in the progression of various diseases such as nervous system diseases, circulatory system diseases, digestive system diseases, locomotor system diseases, reproductive system diseases, endocrine system diseases, urinary system diseases, respiratory system diseases and cancer.
Yong Liu, Zi‐Hui Mao, Junwen Huang, Hui Wang, Xiao Zhang, Xin Zhou, Yue Xu, Shaokang Pan, Dongwei Liu, Zhangsuo Liu, Qi Feng   +10 more
wiley   +1 more source

Prediction of anticancer peptides derived from the true lectins of Phoenix dactylifera and their synergetic effect with mitotane

Frontiers in Pharmacology
Background and aims: Cancer continues to be a significant source of both illness and death on a global scale, traditional medicinal plants continue to serve as a fundamental resource of natural bioactive compounds as an alternative source of remedies ...
Othman Baothman, Othman Baothman, Ehab M. M. Ali, Ehab M. M. Ali, Salman Hosawi, Emadeldin Hassan E. Konozy, Emadeldin Hassan E. Konozy, Isam M. Abu Zeid, Abrar Ahmad, Hisham N. Altayb, Hisham N. Altayb   +10 more
doaj   +1 more source

Role of Scaffold Protein Proline-, Glutamic Acid-, and Leucine-Rich Protein 1 (PELP1) in the Modulation of Adrenocortical Cancer Cell Growth [PDF]

, 2017
PELP1 acts as an estrogen receptor (ER) coactivator that exerts an essential role in the ER's functions. ER coregulators have a critical role in the progression and response to hormonal treatment of estrogen-dependent tumors.
Avena, Paola, Casaburi, Ivan, Chimento, Adele, De Luca, Arianna, Fallo, Francesco, Pezzi, Vincenzo, Pilon, Catia, Sirianni, Rosa   +7 more
core   +2 more sources