Results 1 to 10 of about 2,513 (137)
Total Synthesis and Structural Plasticity of Kratom Pseudoindoxyl Metabolites**
Angewandte Chemie, Volume 135, Issue 35, August 28, 2023., 2023 Although opioids have been used in the treatment of pain for centuries, they cause various adverse effects and addiction. Recently, kratom alkaloids emerged as promising analgesic alternatives for pain management with considerably fewer side effects. The first scalable total synthesis of mitragynine pseudoindoxyl, the most potent atypical opioid kratom
Péter Angyal +9 more
wiley +2 more sources
Applications in Plant Sciences, Volume 11, Issue 6, November-December 2023., 2023 Abstract Premise Rubiaceae is among the most species‐rich plant families, as well as one of the most morphologically and geographically diverse. Currently available phylogenies have mostly relied on few genomic and plastid loci, as opposed to large‐scale genomic data.
Laymon D. Ball +3 more
wiley +1 more source
Biosynthesis of kratom opioids
New Phytologist, Volume 240, Issue 2, Page 757-769, October 2023., 2023 Summary Mitragynine, an analgesic alkaloid from the plant Mitragyna speciosa (kratom), offers a safer alternative to clinical opioids such as morphine, owing to its more favorable side effect profile. Although kratom has been traditionally used for stimulation and pain management in Southeast Asia, the mitragynine biosynthesis pathway has remained ...
Kyunghee Kim +6 more
wiley +1 more source
Clinical Assessment of the Drug Interaction Potential of the Psychotropic Natural Product Kratom
Clinical Pharmacology &Therapeutics, Volume 113, Issue 6, Page 1315-1325, June 2023., 2023 Oral formulations prepared from the leaves of the kratom (Mitragyna speciosa) plant are increasingly used for their opioid‐like effects to self‐manage opioid withdrawal and pain. Calls to US poison centers involving kratom exposures increased >50‐fold from 2011–2017, one‐third of which reported concomitant use of kratom with drugs of abuse.
Rakshit S. Tanna +9 more
wiley +1 more source
The dark web trades wildlife, but mostly for use as drugs
People and Nature, Volume 5, Issue 3, Page 999-1009, June 2023., 2023 Abstract Contemporary wildlife trade is massively facilitated by the Internet. By design, the dark web is one layer of the Internet that is difficult to monitor and continues to lack thorough investigation. Here, we accessed a comprehensive database of dark web marketplaces to search across c. 2 million dark web advertisements over 5 years using c. 7 k
Oliver C. Stringham +14 more
wiley +1 more source
Clinical and Translational Science, Volume 16, Issue 6, Page 1002-1011, June 2023., 2023 Abstract Kratom is a widely used Asian botanical that has gained popularity in the United States due to a perception that it can treat pain, anxiety, and opioid withdrawal symptoms. The American Kratom Association estimates 10–16 million people use kratom.
Xiaotong Li +8 more
wiley +1 more source
Drug testing for mitragynine and kratom: Analytical challenges and medico‐legal considerations
Drug Testing and Analysis, Volume 15, Issue 2, Page 213-219, February 2023., 2023 The use of kratom, that is, leaves from the Southeast Asian tree Mitragyna speciosa, has spread to the Western world. Kratom contain several alkaloids including mitragynine and its three diastereomers mitraciliatine, speciogynine and speciociliatine. In Sweden, only mitragynine is classified.
Anders Helander, Alexia Rylski
wiley +1 more source
Drug and Alcohol Review, Volume 42, Issue 2, Page 401-414, February 2023., 2023 Abstract Introduction Ibogaine is one of the alkaloids naturally found in plants such as Tabernanthe iboga, which has been traditionally used by members of the Bwiti culture. Since the discovery of its anti‐addictive properties by Howard S. Lotsof in 1962, ibogaine has been used experimentally to treat substance use disorders (SUD), especially those ...
Borja J. Rodríguez‐Cano +6 more
wiley +1 more source
Nordic Journal of Botany, Volume 2022, Issue 8, August 2022., 2022 Current vegetation maps show evergreen forests of Cambodia as one homogenous forest type. However, ecological field studies in the central plains demonstrated a heterogenous mosaic of different evergreen forest types, each with a unique species composition and ecological characteristics.
Ida Theilade +5 more
wiley +1 more source
Journal of Cutaneous Pathology, EarlyView.ABSTRACT Background Drug‐induced hyperpigmentation accounts for 10%–20% of acquired pigmentary disorders and can be misdiagnosed for other causes such as melasma, post inflammatory changes, or heavy metal deposition. Kratom (Mitragyna speciosa), a Southeast Asian plant with an opioid‐like profile, has been increasingly used in the United States for ...
Rita Kamoua +4 more
wiley +1 more source