Results 201 to 210 of about 410,804 (309)

Halofuginone is a Molecular Glue Degrader of Integrin β4

Advanced Science, EarlyView.
Integrin β4 overexpression is linked to aggressive tumors and poor prognosis, but targeted therapies are lacking. We identified halofuginone (HF) as a molecular glue degrader that promotes integrin β4 degradation via the CRL4BWDR18 E3 ligase. HF suppresses tumor progression in vitro and in vivo, offering a new strategy for targeting oncogenic ...
Wei Gong, Di Yang, Junrui Tian, Yufei Chai, Tiantian Yu, Qingnan Wu, Yan Wang, Weimin Zhang, Qimin Zhan   +8 more
wiley   +1 more source

Applications of Machine Learning (ML) in the context of marketing: a bibliometric approach. [PDF]

F1000Res
Cardona-Acevedo S, Agudelo-Ceballos E, Arango-Botero D, Valencia-Arias A, Ramírez Dávila JC, Jimenez Garcia JA, Flores Goycochea C, Martínez Rojas E.   +7 more
europepmc   +1 more source

Machine Learning for Green Solvents: Assessment, Selection and Substitution

Advanced Science, EarlyView.
Environmental regulations have intensified demand for green solvents, but discovery is limited by Solvent Selection Guides (SSGs) that quantify solvent sustainability. Training a machine learning model on GlaxoSmithKline SSG, a database of sustainability metrics for 10,189 solvents, GreenSolventDB is developed. Integrated with Hansen solubility metrics,
Rohan Datta, Janhavi Nistane, Abhishek Sose, Harikrishna Sahu, Rampi Ramprasad   +4 more
wiley   +1 more source

Improving sensitivity and drug tolerance of assays for neutralizing anti-drug antibodies to semaglutide and native GLP-1. [PDF]

Bioanalysis
Videbæk N, Jørgensen L, de Lemos Rieper C, Hummelshøj L, Petersen SS, Wøldike DBC, Andresen LO.   +6 more
europepmc   +1 more source

Stabilization of Single Metal Atoms on Graphitic Carbon Nitride: Synthetic Strategies and Emerging Applications

Advanced Science, EarlyView.
This review highlights recent advancements in stabilizing single metal atoms on graphitic carbon nitride emphasizing innovative synthesis strategies and emerging applications in electrocatalysis, photocatalysis and organic transformations, along with key challenges and future perspective. Abstract Emerging as a new frontier in catalysis science, single‐
Wenyao Zhang, Junjie Cui, Zhenjie Yao, Boyuan Zhu, Nithinraj Panangattu Dharmarajan, Ajayan Vinu, Junwu Zhu   +6 more
wiley   +1 more source

Monitoring the impacts of international trade and investment agreements on food environments: a Canadian case study. [PDF]

Public Health Nutr
Schram A, Garton K, Vaillancourt C, Vanderlee L.   +3 more
europepmc   +1 more source

BLADE‐ON‐PETIOLE Genes Enable Genetic Bottleneck Mitigation Through Cross‐Species Repurposing of Floral Persistence Traits

Advanced Science, EarlyView.
This study shows that BLADE‐ON‐PETIOLE (BOP) proteins regulate floral abscission and senescence in tomato by interacting with TFAM1 to form transcriptional condensates controlling the ARABIDOPSIS THALIANA HOMEOBOX GENE 1 (ATH1)‐mediated abscission pathway.
Nan Xiao, Qianwen Lyu, Tinghao Zhang, Yupan Zou, Yue Xie, Dandan Yang, Cao Xu, Xiaozhen Huang   +7 more
wiley   +1 more source

Predicting Consumer Adoption of Luxury Products via Instagram Marketing: A Machine Learning Approach. [PDF]

F1000Res
Nallasivam A, S GK, Jagadeeswari IU, Desai G, Bandhu D.   +4 more
europepmc   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Development of a classification of common interventions to describe the work of local public health agencies. [PDF]

Can J Public Health
Summers A, Kearon J, Maaten S, Gabriel C, Harvey A, Sangster Bouck M, McCann M, Verhaeghe T, DeMars D, Oyelade A.   +9 more
europepmc   +1 more source