Results 91 to 100 of about 12,253 (284)
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Mixed-Criticality Scheduling for TDMA Networks
, 2022 AbstractTo improve the schedulability of mixed-criticality industrial wireless networks, targeted algorithms should be developed. Therefore, in this chapter, we propose a mixed-criticality scheduling algorithm. The algorithm supports centralized optimization and adaptive adjustment. It can improve both the schedulability and flexibility.
Xi Jin, Changqing Xia, Chi Xu, Dong Li
openaire +1 more source
Energy efficient partition allocation in mixed-criticality systems.
PLoS ONE, 2019 This paper addresses the problem of energy management of mixed criticality applications in a multi-core partitioned architecture. Instead of focusing on new scheduling algorithms to adjust frequency in order to save energy, we propose a partition to CPU ...
Ana Guasque +3 more
doaj +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
AVB-Aware Routing and Scheduling of Time-Triggered Traffic for TSN
IEEE Access, 2018 IEEE 802.1 time-sensitive networking (TSN) is a set of amendments to the IEEE 802.1 standard that enable safety-critical and real-time behavior over Ethernet for the industrial automation and automotive domains.
Voica Gavrilut +3 more
doaj +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Balancing Message Criticality and Timeliness in IoT Networks
IEEE Access, 2019 We study the problem of balancing timeliness and criticality when gathering data from multiple sources using a two-level hierarchical approach. The devices that generate the data transmit them to a local hub.
Hootan Rashtian, Sathish Gopalakrishnan
doaj +1 more source
An algorithm for scheduling certifiable mixed-criticality sporadic task systems
, 2010 Many safety-critical embedded systems are subject to certifi-cation requirements. However, only a subset of the functionality of the system may be safety-critical and hence subject to certifica-tion; the rest of the functionality is non safety-critical ...
Sanjoy Baruah, Haohan Li
core +1 more source