Results 71 to 80 of about 12,253 (284)

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Novel Hybrid Scheduling Technique for Sensor Nodes with Mixed Criticality Tasks

Sensors, 2017
Sensor networks become increasingly a key technology for complex control applications. Their potential use in safety- and time-critical domains has raised the need for task scheduling mechanisms specially adapted to sensor node specific requirements ...
Mihai-Victor Micea, Cristina-Sorina Stangaciu, Valentin Stangaciu, Daniel-Ioan Curiac   +3 more
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

A Specification Framework for Mixed-Criticality Scheduling Protocols

ACM Transactions on Embedded Computing Systems
This article presents a general formal framework for describing the relationship between a criticality-aware scheduler, a set of application jobs that are assigned different criticality levels, and an environment that generates both work and faults that the run-time system must control.
Alan Burns 0001, Cliff B. Jones
openaire   +2 more sources

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Mixed Criticality Systems : Beyond Transient Faults

, 2015
Adopting mixed-criticality architectures enable safe sharing of computational resources between tasks of different criticalities consequently leading to reduced Size, Weight and Power (SWaP) requirements.
Burns, Alan,, Thekkilakattil, Abhilash,, Punnekkat, Sasikumar,, Dobrin, Radu,   +3 more
core  

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Mixed Criticality Reward-Based Systems Using Resource Reservation

IEEE Access
Real-time systems mostly interact with the external world and each input operation must meet predetermined deadlines to be useful. However, in many real-time applications, a partial result is also acceptable. We developed a reward-based mixed criticality
Amjad Ali, Shah Zeb, Madallah Alruwaili, Asad Masood Khattak, Bashir Hayat, Ki-Il Kim   +5 more
doaj   +1 more source

Fault-Tolerant and Real-Time Scheduling for Mixed-Criticality Systems

, 2014
The design and analysis of real-time scheduling algorithms for safety-critical systems is a challenging problem due to the temporal dependencies among different design constraints.
Pathan, Risat, Pathan, Risat,
core   +1 more source