Results 101 to 110 of about 54,272 (293)

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Self Diagnostics and Isolation Mechanisms for Mixed Criticality Systems

Journal of Communications Software and Systems, 2019
Virtualization is a technology that is frequently employed in computers and servers to provide isolation for execution environments, and to support the execution of multiple Operating Systems (OS) on the same hardware platform.
Asmaa Tellabi, Christoph Ruland, Karl Waedt, Abdelbast Sabri   +3 more
doaj  

Improving Real-Time Performance Under Reliability Requirement Assurance in Automotive Electronic Systems

IEEE Access, 2019
The architecture of modern automotive electronic systems is composed of multiple distributed mixed-criticality functions. The effective utilization of such systems with heterogeneity is hindered by the scheduling of multifunctions.
Yan Liu, Guoqi Xie, Yuqing Tang, Renfa Li   +3 more
doaj   +1 more source

Mean-Field-Theory for Polymers in Mixed Solvents Thermodynamic and Structural Properties

, 1999
Theoretical aspects of polymers in mixed solvents are considered using the Edwards Hamiltonian formalism. Thermodynamic and structural properties are investigated and some predictions are made when the mixed solvent approaches criticality.
Bemouna, M., Negadi, A., Sans-Penninckx, A., Vilgis, T. A.   +3 more
core   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Energy-Efficient Algorithm for Mixed-Criticality Systems in E-Learning Environment [PDF]

Interdisciplinary Journal of Virtual Learning in Medical Sciences, 2019
Background: Low-energy consumption is a vital concern in E-learning due to high-volume processing and the fact that mobile technologies are usually battery-operated devices. Methods: The method is simulated by developing a discrete-event simulation in C#.
Seyed Hasan Sadeghzadeh
doaj  

Embedded Multi-Core systems for Mixed Criticality applications in dynamic and changeable real-time environments [PDF]

, 2015
EMC2 finds solutions for dynamic adaptability in open systems. It provides handling of mixed criticality multicore applications in r eal-time conditions, withscalability and utmost flexibility, full-scale deployment and management of integrated tool ...
Tovar, Eduardo
core  

New Universality Class of Quantum Criticality in Ce- and Yb-based Heavy Fermions

, 2012
A new universality class of quantum criticality emerging in itinerant electron systems with strong local electron correlations is discussed. The quantum criticality of a Ce- or Yb-valence transition gives us a unified explanation for unconventional ...
Abrikosov A A, Coleman P, Gschneidner K A, Jeong T, Kazumasa Miyake, Kitayama S, Kobayashi T C, Matsumoto Y, Miyake K, Moriya T, Parm E C, Petrovic C, Shinji Watanabe, Wada S, Watanabe S, Watanabe S Miyake K, Yashima M Tagami N Taniguchi S Unemori T Uematsu K Mukuda H Kitaoka Y Ōta Y Honda F Settai R Ōnuki Y, Yasui A   +17 more
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source