Results 81 to 90 of about 2,721 (244)

Improving Real-Time Performance Under Reliability Requirement Assurance in Automotive Electronic Systems

IEEE Access, 2019
The architecture of modern automotive electronic systems is composed of multiple distributed mixed-criticality functions. The effective utilization of such systems with heterogeneity is hindered by the scheduling of multifunctions.
Yan Liu, Guoqi Xie, Yuqing Tang, Renfa Li   +3 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Scheduling Mixed-Criticality Systems on Varying-Speed Processors: A Meta-Reinforcement Learning Approach for Non-Preemptive Tasks

IEEE Access
Mixed-Criticality (MC) systems have to guarantee the timely execution of high-criticality tasks even under adversarial processor conditions. Prior work addresses preemptive scheduling, leaving the NP hard, non-preemptive scheduling problem unexplored ...
Muhammad ElMahdy, Rodrigo A. Carrasco, Nourhan Sakr   +2 more
doaj   +1 more source

Energy-Efficient Algorithm for Mixed-Criticality Systems in E-Learning Environment [PDF]

Interdisciplinary Journal of Virtual Learning in Medical Sciences, 2019
Background: Low-energy consumption is a vital concern in E-learning due to high-volume processing and the fact that mobile technologies are usually battery-operated devices. Methods: The method is simulated by developing a discrete-event simulation in C#.
Seyed Hasan Sadeghzadeh
doaj  

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Robust Communication Design in RIS-Assisted THz Channels

IEEE Open Journal of the Communications Society
Terahertz (THz) communication offers the necessary bandwidth to meet the high data rate demands of next-generation wireless systems. However, it faces significant challenges, including severe path loss, dynamic blockages, and beam misalignment, which ...
Yasemin Karacora, Adam Umra, Aydin Sezgin   +2 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

ReTMiC: Reliability-Aware Thermal Management in Multicore Mixed-Criticality Embedded Systems

IEEE Access
As the number of cores in multicore platforms increases, temperature constraints may prevent powering all cores simultaneously at maximum voltage and frequency level.
Sepideh Safari, Mohsen Ansari, Shaahin Hessabi, Jorg Henkel   +3 more
doaj   +1 more source