Results 71 to 80 of about 2,927 (259)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Development of Real-Time and Mixed Criticality Distributed Systems through the DDS Standard
Revista Iberoamericana de Automática e Informática Industrial RIAI, 2018 The use of distribution middleware facilitates the programming of heterogeneous real-time distributed systems, and it can also facilitate the automatic generation of source code when integrated as a part of a general MDE (Model-Driven Engineering ...
Héctor Pérez Tijero +1 more
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Self Diagnostics and Isolation Mechanisms for Mixed Criticality Systems
Journal of Communications Software and Systems, 2019 Virtualization is a technology that is frequently employed in computers and servers to provide isolation for execution environments, and to support the execution of multiple Operating Systems (OS) on the same hardware platform.
Asmaa Tellabi +3 more
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Energy-Efficient Algorithm for Mixed-Criticality Systems in E-Learning Environment [PDF]
Interdisciplinary Journal of Virtual Learning in Medical Sciences, 2019 Background: Low-energy consumption is a vital concern in E-learning due to high-volume processing and the fact that mobile technologies are usually battery-operated devices. Methods: The method is simulated by developing a discrete-event simulation in C#.
Seyed Hasan Sadeghzadeh
doaj
IEEE Access, 2019 The architecture of modern automotive electronic systems is composed of multiple distributed mixed-criticality functions. The effective utilization of such systems with heterogeneity is hindered by the scheduling of multifunctions.
Yan Liu +3 more
doaj +1 more source