Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
Enhancing the Resilience of ROS 2-Based Multi-Robot Systems with Kubernetes: A Case Study on UWB-Based Relative Positioning. [PDF]
Zhang J, Yu X, Westerlund T.
europepmc +1 more source
Functional Connectivity Linked to Cognitive Recovery After Minor Stroke
ABSTRACT Objective Patients with minor stroke exhibit slowed processing speed and generalized alterations in functional connectivity involving frontoparietal cortex (FPC). The pattern of connectivity evolves over time. In this study, we examine the relationship of functional connectivity patterns to cognitive performance, to determine ...
Vrishab Commuri +7 more
wiley +1 more source
Observation of Complete Orbital Two-Channel Kondo Effect in van der Waals Ferromagnet Fe3GaTe2. [PDF]
Bao C +7 more
europepmc +1 more source
Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease
ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky +8 more
wiley +1 more source
Optimizing concrete pump maintenance in the construction sector using enhanced MCDM techniques. [PDF]
Deepak D +6 more
europepmc +1 more source
Preconfigured neuronal firing sequences in human brain organoids. [PDF]
van der Molen T +31 more
europepmc +1 more source
Personalized Learning With Artificial Intelligence in Dental Education: An Integrative Review. [PDF]
Bh MP +4 more
europepmc +1 more source
Non-linearity, complexity, and quantization concepts in biology. [PDF]
Theise ND, Tuszynski JA.
europepmc +1 more source

