Results 51 to 60 of about 17,397,225 (294)
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Variable Selection for Generalized Linear Mixed Models by L1-Penalized Estimation [PDF]
, 2011 Generalized linear mixed models are a widely used tool for modeling longitudinal data. However, their use is typically restricted to few covariates, because the presence of many predictors yields unstable estimates.
Groll, Andreas
core +3 more sources
Frontiers in Neuroscience, 2018 Given the increasing amount of neuroimaging studies, there is a growing need to summarize published results. Coordinate-based meta-analyses use the locations of statistically significant local maxima with possibly the associated effect sizes to aggregate
Han Bossier +10 more
doaj +1 more source
Improving the Computation of Brier Scores for Evaluating Expert-Elicited Judgements
Frontiers in Applied Mathematics and Statistics, 2021 Structured expert judgement (SEJ) is a suite of techniques used to elicit expert predictions, e.g. probability predictions of the occurrence of events, for situations in which data are too expensive or impossible to obtain.
Gayan Dharmarathne +2 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Statistical estimation in partially nonlinear models with random effects
Statistical Theory and Related Fields, 2017 In this article, a partially nonlinear model with random effects is proposed and its new estimation procession is provided. In order to estimate the link function, we propose generalised least square estimate and B-splines estimate methods.
Ye Que, Zhensheng Huang, Riquan Zhang
doaj +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Statistics and Public Policy, 2019 Mixed-effects models were used to evaluate the global zoning concept using residue data from a comprehensive database of supervised field trials performed in various countries and regions on a variety of pesticide–crop combinations.
James Nguyen +3 more
doaj +1 more source
, 2016 In (a), the models study the effect of session length on the quality of the first comment C1 in a session; i.e., data only contains the first session comments.
Farshad Kooti (3080265) +4 more
core +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source