Results 91 to 100 of about 5,761,259 (326)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Evaluation of Mixed-mode Integral Invariant for Polymer Material Trough The Couple Experimental-Numerical Process

EPJ Web of Conferences, 2010
Usually the element of real structures is subject of the mixed mode loadings. This fact can be explained by the elements geometry and the loading orientations.
Absi J., Dubois F., Pop O., Meite M.
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Long Tailed Maps as a Representation of Mixed Mode Oscillatory Systems

, 2004
Mixed mode oscillatory (MMO) systems are known to exhibit some generic features such as the reversal of period doubling sequences and crossover to period adding sequences as bifurcation parameters are varied.
Albahadily, Ananthakrishna, Ananthakrishna, Ananthakrishna, Argoul, Arneodo, Bagley, Bassett, Bier, Braun, Braun, Chay, Coffman, Coffman, Corbet, Dawson, Dawson, Doona, Fang, Ferdinando de Tamosi, G. Ananthakrishna, Gardini, Gaspard, Gaspard, Geisel, Glenndining, Goryachev, Guckenheimer, Gyorgi, Hauser, Ibibson, Kan, Koper, Koper, Koper, Krischer, Lorenz, Metropolis, Michelin, Noszticzius, Nusse, Oblow, Parlitz, Parlitz, Petrov, Pikovsky, Post, Rajesh, Rajesh, Rajesh, Rajesh Raghavan, Ringland, Ringland, Schintuchand, Simoyi, Turner, Xu   +56 more
core   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Weak anion-exchange hypercrosslinked sorbent in on-line solid-phase extraction-liquid chromatography coupling to achieve automated determination with an effective clean-up [PDF]

, 2010
A mixed-mode polymeric sorbent was on-line coupled to liquid chromatography (LC) for the first time and applied it to the selective solid-phase extract a group of pharmaceuticals in complex environmental water samples. The mixed-mode polymeric sorbent is
Borrull, F., Cormack, P.A.G., Fontanals, N., Marce, R.M., Sherrington, D.C.   +4 more
core   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Slow Manifold Structure and the Emergence of Mixed-Mode Oscillations

, 1997
A detailed study of the slow manifold of a model exhibiting mixed-mode oscillations is presented. A scenario for the emergence of mixed-mode states which does not involve phase locking on a 2-torus is constructed.
Goryachev, Andrei, Kapral, Raymond, Strizhak, Peter   +2 more
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Measurements of mixed-mode crack surface displacements and comparison with theory [PDF]

A theoretical and an experimental technique is used to determine crack surface displacements under mixed-mode conditions. Crack surface displacements proved to be quite useful in mode 1 fracture analysis in that they are directly related to strain energy
Altiero, N. J., Jr., Sharpe, W. N., Jr.
core   +1 more source